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Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS (2021)
Journal Article
Dyke, K., Pépés, S. E., Babourina-Brooks, B., Chen, C., Kim, S., Sigurdsson, H. P., …Jackson, S. R. (2021). Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS. NeuroImage: Reports, 1(1), Article 100003. https://doi.org/10.1016/j.ynirp.2021.100003

Age-related differences in myeloarchitecture measured at 7 T (2020)
Journal Article
Carradus, A. J., Mougin, O., Hunt, B. A., Tewarie, P. K., Geades, N., Morris, P. G., …Madan, C. R. (2020). Age-related differences in myeloarchitecture measured at 7 T. Neurobiology of Aging, 96, 246-254. https://doi.org/10.1016/j.neurobiolaging.2020.08.009

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in... Read More about Age-related differences in myeloarchitecture measured at 7 T.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.

Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI (2017)
Journal Article
Dyke, K., Pépés, S. E., Chen, C., Kim, S., Sigurdsson, H. P., Draper, A., …Jackson, S. R. (2017). Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI. NeuroImage, 152, 360-370. https://doi.org/10.1016/j.neuroimage.2017.03.011

Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many brain and mental health disorders, and for this reason there is considerable interest in investigating how individual var... Read More about Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI.

Modulation of post-movement beta rebound by contraction force and rate of force development (2016)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Barratt, E. L., Morris, P. G., Bauer, M., …Brookes, M. J. (2016). Modulation of post-movement beta rebound by contraction force and rate of force development. Human Brain Mapping, 37(7), https://doi.org/10.1002/hbm.23189

Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory phenomena in the brain. In the preparation and execution phases of movement, a loss in beta amplitude is observed (movement related beta decrease (MRBD)). Thi... Read More about Modulation of post-movement beta rebound by contraction force and rate of force development.

Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome (2014)
Journal Article
Stephenson, M., Morgan, P., Draper, A., Stephenson, M. C., Jackson, G., Pépés, S., …Jackson, S. (2014). Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome. Current Biology, 24(19), 2343-2347. https://doi.org/10.1016/j.cub.2014.08.038

Tourette syndrome (TS) is a developmental neurological disorder characterized by vocal and motor tics [1] and associated with cortical-striatal-thalamic-cortical circuit dysfunction [2, 3], hyperexcitability within cortical motor areas [4], and alter... Read More about Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome.

tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7T magnetic resonance spectroscopy study (2014)
Journal Article
Kim, S., Stephenson, M. C., Morris, P. G., & Jackson, S. R. (2014). tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7T magnetic resonance spectroscopy study. NeuroImage, 99, 237-243. https://doi.org/10.1016/j.neuroimage.2014.05.070

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that alters cortical excitability in a polarity specific manner and has been shown to influence learning and memory. tDCS may have both on-line and after-eff... Read More about tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7T magnetic resonance spectroscopy study.