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All Outputs (10)

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., …Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., …Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.

From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures (2023)
Journal Article
Cassaday, H. J., Muir, C., Stevenson, C. W., Bonardi, C., Hock, R., & Waite, L. (2023). From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures. Neurobiology of Learning and Memory, 202, Article 107757. https://doi.org/10.1016/j.nlm.2023.107757

Inhibitory associative learning counters the effects of excitatory learning, whether appetitively or aversively motivated. Moreover, the affective responses accompanying the inhibitory associations are of opponent valence to the excitatory conditione... Read More about From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures.

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Warren, W. G., Papagianni, E. P., Hale, E., Brociek, R. A., Cassaday, H. J., & Stevenson, C. W. (2022). Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in Pharmacology, 13, Article 1082760. https://doi.org/10.3389/fphar.2022.1082760

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Papagianni, E. P., Warren, W. G., Cassaday, H. J., & Stevenson, C. W. (2022). Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance. International Journal of Molecular Sciences, 23(16), Article 9333. https://doi.org/10.3390/ijms23169333

Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.

URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
Warren, W. G., Hale, E., Papagianni, E. P., Cassaday, H. J., Stevenson, C. W., & Stubbendorff, C. (2022). URB597 induces subtle changes to aggression in adult Lister Hooded rats. Frontiers in Psychiatry, 13, Article 885146. https://doi.org/10.3389/fpsyt.2022.885146

The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. (2022). Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition. eNeuro, 9(1), ENEURO.0270-21.2021. https://doi.org/10.1523/eneuro.0270-21.2021

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Working Paper
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

Bidirectional effects of cannabidiol on contextual fear memory extinction (2016)
Journal Article
Song, C., Stevenson, C. W., Guimaraes, F. S., & Lee, J. L. (2016). Bidirectional effects of cannabidiol on contextual fear memory extinction. Frontiers in Pharmacology, 7(493), https://doi.org/10.3389/fphar.2016.00493

Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation. Here, we... Read More about Bidirectional effects of cannabidiol on contextual fear memory extinction.