All Outputs (35)

Spatio-Temporal Motility MRI analysis of the stomach and colon (2019)
Journal Article
Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), Article e13557. https://doi.org/10.1111/nmo.13557

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal m... Read More about Spatio-Temporal Motility MRI analysis of the stomach and colon.

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold (2018)
Journal Article
Hoad, C., Marciani, L., Spiller, R., Gowland, P., & Moran, G. (2019). Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold. Neurogastroenterology and Motility, 31(1), e13466. https://doi.org/10.1111/nmo.13466

Background The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract in an u... Read More about Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold.

Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects (2018)
Journal Article
Parker, H., Hoad, C. L., Tucker, E., Costigan, C., Marciani, L., Gowland, P., & Fox, M. (2018). Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects. Neurogastroenterology and Motility, 30(12), Article e13463. https://doi.org/10.1111/nmo.13463

Background: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Not... Read More about Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects.

Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging (2018)
Journal Article
Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., …Spiller, R. C. (2018). Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility, 30(9), Article e13400. https://doi.org/10.1111/nmo.13400

Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constip... Read More about Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging.

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans (2017)
Journal Article
Khalaf, A., Hoad, C., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., …Moran, G. W. (2018). MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology and Motility, 30(1), Article e13182. https://doi.org/10.1111/nmo.13182

Background: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility... Read More about MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article
Murray, K., Hoad, C. L., Mudie, D. M., Wright, J., Heissam, K., Abrehart, N., …Marciani, L. (2017). Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans. Molecular Pharmaceutics, 14(8), 2629-2638. https://doi.org/10.1021/acs.molpharmaceut.7b00095

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More about Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans.

Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects (2017)
Journal Article
Parker, H. L., Tucker, E., Blackshaw, E., Hoad, C., Marciani, L., Perkins, A., …Fox, M. (2017). Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects. Neurogastroenterology and Motility, 29(11), e13122. https://doi.org/10.1111/nmo.13122

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study presents the reference intervals of the m... Read More about Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects.

Assessment of motion of colonic contents in the human colon using MRI tagging (2017)
Journal Article
Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., & Hoad, C. (2017). Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and Motility, 29(9), Article e13091. https://doi.org/10.1111/nmo.13091

Background We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to vi... Read More about Assessment of motion of colonic contents in the human colon using MRI tagging.

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome (2016)
Journal Article
Major, G., Pritchard, S. E., Murray, K., Alappadan, J. P., Hoad, C., Marciani, L., …Spiller, R. C. (2017). Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome. Gastroenterology, 152(1), 124-133.e2. https://doi.org/10.1053/j.gastro.2016.09.062

Background & Aims: Poorly digested, fermentable carbohydrates may induce symptoms of irritable bowel syndrome (IBS), via unclear mechanisms. We performed a randomized trial with magnetic resonance imaging (MRI) analysis to investigate correlations be... Read More about Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.

Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial (2016)
Journal Article
Murray, K., Lam, C., Rehman, S., Marciani, L., Costigan, C., Hoad, C., …Spiller, R. C. (2016). Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial. American Journal of Clinical Nutrition, 103(5), https://doi.org/10.3945/ajcn.115.125047

Background: Poorly absorbed, fermentable carbohydrates can provoke irritable bowel syndrome (IBS) symptoms by escaping absorption in the small bowel and being rapidly fermented in the colon in some susceptible subjects. IBS patients are often anxious... Read More about Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial.

Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI (2015)
Journal Article
Hoad, C., Menys, A., Garsed, K., Marciani, L., Hamy, V., Murray, K., …Gowland, P. A. (2016). Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI. Neurogastroenterology and Motility, 28(3), 327-335. https://doi.org/10.1111/nmo.12727

Background Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi-au... Read More about Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI.

Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults (2015)
Journal Article
Hussein, M., Hoad, C., Wright, J., Singh, G., Stephenson, M., Cox, E., …Marciani, L. (2015). Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults. Journal of Nutrition, 145(6), 1170-1177. https://doi.org/10.3945/jn.114.204339

Background: Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses. Objectives: We tested the hypotheses that gastrointestinal physiologic responses and satiety will be i... Read More about Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults.

Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects (2013)
Journal Article
Chaddock, G., Lam, C., Hoad, C., Costigan, C., Cox, E. F., Placidi, E., …Spiller, R. C. (2014). Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26(2), 205-214. https://doi.org/10.1111/nmo.12249

Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for mea... Read More about Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.

Effects of various food ingredients on gall bladder emptying (2013)
Journal Article
Marciani, L., Cox, E., Hoad, C., Totman, J. J., Costigan, C., Singh, G., …Spiller, R. C. (2013). Effects of various food ingredients on gall bladder emptying. European Journal of Clinical Nutrition, 67(11), https://doi.org/10.1038/ejcn.2013.168

Background/objectives: The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. We hypothesized that d... Read More about Effects of various food ingredients on gall bladder emptying.