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Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties (2019)
Journal Article
Okesola, B. O., Lau, H. K., Derkus, B., Boccorh, D. K., Wu, Y., Wark, A. W., …Mata, A. (2020). Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties. Biomaterials Science, 8(3), 846-857. https://doi.org/10.1039/c9bm01796h

Covalent co-assembly holds great promise for the fabrication of hydrogels with controllable nanostructure, versatile chemical composition, and enhanced mechanical properties given its relative simplicity, high efficiency, and bond stability. This rep... Read More about Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties.

‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow-up of a pragmatic randomised controlled trial (2019)
Journal Article
Elliott, R. A., Boyd, M., Tanajewski, L., Barber, N., Gkountouras, G., Avery, A. J., …Chuter, A. (2019). ‘New Medicine Service’: supporting adherence in people starting a new medication for a long-term condition: 26-week follow-up of a pragmatic randomised controlled trial. BMJ Quality and Safety, 29(4), 286-295. https://doi.org/10.1136/bmjqs-2018-009177

Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca (2019)
Journal Article
Dippold, D., Bridges, S., Eccles, S., & Mullen, E. (2019). Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca. Linguistics and Education, 54, Article 100761. https://doi.org/10.1016/j.linged.2019.100761

This paper explores how principles derived from English as a lingua franca (ELF) research (e.g. accommodation, strategic competence) can provide insights into the speaking demands of group work in Anglophone EMI settings which includes native speaker... Read More about Taking ELF off the shelf: Developing HE students’ speaking skills through a focus on English as a lingua franca.

LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate (2019)
Journal Article
Al-Natour, M. A., Alazzo, A., Ghaemmaghami, A. M., Kim, D., & Alexander, C. (2019). LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate. International Journal of Pharmaceutics: X, 1, Article 100036. https://doi.org/10.1016/j.ijpx.2019.100036

Methotrexate (MTX) is a folate analogue antimetabolite widely used for the treatment of rheumatoid arthritis and cancer. A number of studies have shown that MTX delivered via nanoparticle carriers is more potent against cancer cells than free MTX, a... Read More about LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate.

Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells (2019)
Journal Article
Quilles Junior, J. C., Bradshaw, T. D., Turyanska, L., Carlos, F. D. R. R., Montanari, A., Leitão, A., …Bradshaw, T. D. (2019). Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances, 9(63), 36699-36706. https://doi.org/10.1039/c9ra07161j

Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated... Read More about Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells.

Is rat a good model for assessment of particulate-based taste-masked formulations? (2019)
Journal Article
Ali, J., Chiang, M., Lee, J. B., Voronin, G. O., Bennett, J., Cram, A., …Gershkovich, P. (2020). Is rat a good model for assessment of particulate-based taste-masked formulations?. European Journal of Pharmaceutics and Biopharmaceutics, 146, 1-9. https://doi.org/10.1016/j.ejpb.2019.11.001

Recently there has been an increased interest to develop specialised dosage forms that are better suited to specific patient populations, such as paediatrics and geriatrics. In these patient populations the acceptability of the oral dosage form can b... Read More about Is rat a good model for assessment of particulate-based taste-masked formulations?.

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article
Yoo, J., Clark, E. A., Wallace, M. J., Irvine, D. J., Alexander, M. R., Roberts, C. J., & Wildman, R. D. (2020). Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing. International Journal of Pharmaceutics, 578, https://doi.org/10.1016/j.ijpharm.2019.118805

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Biomedical applications of composite resorbable fibers (2019)
Book Chapter
Said, S. S., Eltaher, H. M., & El-Khordagui, L. K. (2019). Biomedical applications of composite resorbable fibers. In Materials for Biomedical Engineering: Absorbable Polymers (127-155). Elsevier. https://doi.org/10.1016/B978-0-12-818415-8.00005-X

Polymer fibers, particularly electrospun resorbable nanofibers, are attracting growing attention in biomedical applications because of their biocompatibility, biodegradability, and outstanding structural properties. Resorbable nanofibers demonstrated... Read More about Biomedical applications of composite resorbable fibers.

Men's views of antidepressant treatment for depression, and their implications for community pharmacy practice (2019)
Journal Article
Brydges, S., Rennick- Egglestone, S., & Anderson, C. (2020). Men's views of antidepressant treatment for depression, and their implications for community pharmacy practice. Research in Social and Administrative Pharmacy, 16(8), 1041-1049. https://doi.org/10.1016/j.sapharm.2019.10.016

Background Men with depression can express and navigate their condition differently to women. Understanding this population's needs, and experiences, can help healthcare professionals better support these patients. There is a lack of knowledge in... Read More about Men's views of antidepressant treatment for depression, and their implications for community pharmacy practice.

Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung (2019)
Journal Article
Nieto-Orellana, A., Li, H., Rosiere, R., Wauthoz, N., Williams, H., Monteiro, C., …Stolnik, S. (2019). Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung. Journal of Controlled Release, 316, 250-262. https://doi.org/10.1016/j.jconrel.2019.10.012

Pulmonary delivery is increasingly seen as an attractive, non-invasive route for the delivery of forthcoming protein therapeutics. In this context, here we describe protein complexes with a new ‘complexing excipient’ - vitamin B12-targeted poly(ethyl... Read More about Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin (2019)
Journal Article
Lee, J. B., Radhi, M., Cipolla, E., Gandhi, R. D., Sarmad, S., Zgair, A., …Gershkovich, P. (2019). A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin. Scientific Reports, 9, Article 15760. https://doi.org/10.1038/s41598-019-52254-x

Although adenosine and its analogues have been assessed in the past as potential drug candidates due to the important role of adenosine in physiology, only little is known about their absorption following oral administration. In this work, we have st... Read More about A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.

Solid lipid nanoparticles self-assembled from spray dried microparticles (2019)
Journal Article
Sanchez-Vazquez, B., Lee, J. B., Strimaite, M., Buanz, A., Bailey, R., Gershkovich, P., …Williams, G. R. (2019). Solid lipid nanoparticles self-assembled from spray dried microparticles. International Journal of Pharmaceutics, 572, Article 118784. https://doi.org/10.1016/j.ijpharm.2019.118784

We report the self-assembly of drug-loaded solid lipid nanoparticles (SLNs) from spray dried microparticles comprising poly(vinylpyrrolidone) (PVP) loaded with glyceryl tristearate (GTS) and either indomethacin (IMC) or 5-fluorouracil (5-FU). When th... Read More about Solid lipid nanoparticles self-assembled from spray dried microparticles.

Direct liquid extraction surface analysis mass spectrometry of cell wall lipids from mycobacteria: Salt additives for decreased spectral complexity (2019)
Journal Article
Conner, A. N., Jarvis, J. R., Alderwick, L. J., & Griffiths, R. L. (2021). Direct liquid extraction surface analysis mass spectrometry of cell wall lipids from mycobacteria: Salt additives for decreased spectral complexity. Rapid Communications in Mass Spectrometry, 35(S2), https://doi.org/10.1002/rcm.8523

Rationale Lipids are important mycobacterium cell wall constituents; changes are linked with drug resistance. Liquid extraction surface analysis (LESA) enables direct sampling in a highly sensitive manner. Here we describe protocols for the analys... Read More about Direct liquid extraction surface analysis mass spectrometry of cell wall lipids from mycobacteria: Salt additives for decreased spectral complexity.

Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats. Journal of Biomaterials Science, Polymer Edition, 31(2), 141-154. https://doi.org/10.1080/09205063.2019.1680926

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed Am... Read More about Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats.

In search of effective therapies to overcome resistance to Temozolomide in brain tumours (2019)
Journal Article
Grundy, R., Bouzinab, K., Summers, H., Zhang, J., Stevens, M. F. G., Moody, C. J., …Bradshaw, T. D. (2019). In search of effective therapies to overcome resistance to Temozolomide in brain tumours. Cancer Drug Resistance, 2(4), 1018-1031. https://doi.org/10.20517/cdr.2019.64

Glioblastoma multiforme is the most common and lethal brain tumour-type. The current standard of care includes Temozolomide (TMZ) chemotherapy. However, inherent and acquired resistance to TMZ thwart successful treatment. The direct repair protein me... Read More about In search of effective therapies to overcome resistance to Temozolomide in brain tumours.

Towards equity: a qualitative exploration of the implementation and impact of a digital educational intervention for pharmacy professionals in England (2019)
Journal Article
Latif, A., Waring, J., Pollock, K., Solomon, J., Gulzar, N., Choudhary, S., & Anderson, C. (2019). Towards equity: a qualitative exploration of the implementation and impact of a digital educational intervention for pharmacy professionals in England. International Journal for Equity in Health, 18, Article 151. https://doi.org/10.1186/s12939-019-1069-0

Background Patients belonging to marginalised (medically under-served) groups experience problems with medicines (i.e. non-adherence, side effects) and poorer health outcomes largely due to inequitable access to healthcare (arising from poor governa... Read More about Towards equity: a qualitative exploration of the implementation and impact of a digital educational intervention for pharmacy professionals in England.

Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors (2019)
Journal Article
Shuai, W., Li, W., Yin, Y., Yang, L., Xu, F., Xu, S., …Xu, J. (2019). Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors. Future Medicinal Chemistry, 11(20), 2687-2699. https://doi.org/10.4155/fmc-2019-0125

A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Results: Most of the target compounds exhibited potent anti-AChE act... Read More about Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors.

NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization (2019)
Journal Article
Soave, M., Kellam, B., Woolard, J., Briddon, S. J., & Hill, S. J. (2019). NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization. Slas Discovery, https://doi.org/10.1177/2472555219880475

Receptor internalization in response to prolonged agonist treatment is an important regulator of G protein–coupled receptor (GPCR) function. The adenosine A1 receptor (A1AR) is one of the adenosine receptor family of GPCRs, and evidence for its agoni... Read More about NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization.