Research Repository

See what's under the surface


Evolutionary Drivers of Protein Shape (2019)
Journal Article
Shannon, G., Marples, C. R., Toofanny, R. D., & Williams, P. M. (2019). Evolutionary Drivers of Protein Shape. Scientific Reports, 9(1), doi:10.1038/s41598-019-47337-8

Diffusional motion within the crowded environment of the cell is known to be crucial to cellular function as it drives the interactions of proteins. However, the relationships between protein diffusion, shape and interaction, and the evolutionary sel... Read More

Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments (2019)
Journal Article
Phan, H., Minut, R. I., McCrorie, P., Vasey, C., Larder, R. R., Krumins, E., …Pearce, A. K. (2019). Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments. Journal of Polymer Science Part A: Polymer Chemistry, doi:10.1002/pola.29451

The production of well-defined and reproducible poly-meric nanoparticles (NPs), in terms of size and stability in biological environments, is undoubtedly a fundamental challenge in the formulation of novel and more effective nanomedicines. The adopti... Read More

Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction (2019)
Journal Article
Sloan, T. J., Murray, E., Yokoyama, M., Massey, R. C., Chan, W. C., Bonev, B., & Williams, P. (2019). Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction. Journal of Bacteriology, doi:10.1128/jb.00409-19

Mutations in the polymorphic Staphylococcus aureus agr locus responsible for quorum sensing (QS) dependent virulence gene regulation occur frequently during host adaptation. In two genomically closely related S. aureus clinical isolates exhibiting ma... Read More

Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo (2019)
Journal Article
Singh, N., Romero, M., Travanut, A., Monteiro, P., Jordana-Lluch, E., Hardie, K. R., …Alexander, C. (2019). Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo. Biomaterials Science, doi:10.1039/C9BM00773C

Many debilitating infections result from persistent microbial biofilms that do not respond to conventional antibiotic regimens. A potential method to treat such chronic infections is to combine agents which interfere with bacterial biofilm developmen... Read More

Multifunctional bio-instructive 3D architectures to modulate cellular behaviour (2019)
Journal Article
Vaithilingam, J., Sanjuán-Alberte, P., Campora, S., Rance, G. A., Jiang, L., Tuck, C. J., …Rawson, F. J. (2019). Multifunctional bio-instructive 3D architectures to modulate cellular behaviour. Advanced Functional Materials, doi:10.1002/adfm.201902016

Biological structures control cell behaviour via physical, chemical, electrical and mechanical cues. Approaches that allow us to build devices that mimic these cues in a combinatorial way are lacking due to there being no suitable instructive materia... Read More

Identifying 'avoidable harm' in family practice: a RAND/UCLA Appropriateness Method consensus study (2019)
Journal Article
Carson-Stevens, A., Campbell, S., Cooper, A., Armstrong, S., Ashcroft, D., Boyd, M., …Avery, A. (in press). Identifying 'avoidable harm' in family practice: a RAND/UCLA Appropriateness Method consensus study. BMC Family Practice,

Background: Health care-related harm is an internationally recognized threat to public health. The United Kingdom’s national health services demonstrate that upwards of 90% of health care encounters can be delivered in ambulatory settings. Other coun... Read More

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations (2019)
Journal Article
Zhou, Z., Ruiz Cantu, L., Chen, X., Alexander, M. R., Roberts, C. J., Hague, R., …Wildman, R. (2019). High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations. Additive Manufacturing, 29, doi:10.1016/j.addma.2019.100792

Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting... Read More

The development of a foundation-level pharmacy competency framework: An analysis of country-level applicability of the Global Competency Framework (2019)
Journal Article
Arakawa, N., Yamamura, S., Duggan, C., & Bates, I. (2019). The development of a foundation-level pharmacy competency framework: An analysis of country-level applicability of the Global Competency Framework. Research in Social and Administrative Pharmacy, doi:10.1016/j.sapharm.2019.06.007

Background The importance and usefulness of competency frameworks (CFs) in pharmacy professional development is recognised globally. However, there is no national CF for pharmacists in Japan yet. Objective This study was conducted to measure the... Read More

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localized gene delivery to multiple cell types: From development to application in tissue engineering (2019)
Journal Article
Raftery, R. M., Walsh, D. P., Blokpoel Ferreras, L., Mencía Castaño, I., Chen, G., LeMoine, M., …O'Brien, F. J. (2019). Highly versatile cell-penetrating peptide loaded scaffold for efficient and localized gene delivery to multiple cell types: From development to application in tissue engineering. Biomaterials, 216, doi:10.1016/j.biomaterials.2019.119277

Gene therapy has recently come of age with seven viral vector-based therapies gaining regulatory approval in recent years. In tissue engineering, non-viral vectors are preferred over viral vectors, however, lower transfection efficiencies and difficu... Read More

Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases (2019)
Journal Article
Limón, D., Talló Domínguez, K., Garduño-Ramírez, M. L., Andrade, B., Calpena, A. C., & Pérez-García, L. (2019). Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases. Colloids and Surfaces B: Biointerfaces, 181, 657-670. doi:10.1016/j.colsurfb.2019.06.018

Supramolecular hydrogels were synthesized using a bis-imidazolium based amphiphile, and incorporating chemically diverse drugs, such as the cytostatics gemcitabine hydrochloride and methotrexate sodium salt, the immunosuppressive drug tacrolimus, as... Read More

Principal nested shape space analysis of molecular dynamics data (2019)
Journal Article
Dryden, I. L., Kim, K., Laughton, C. A., & Le, H. (in press). Principal nested shape space analysis of molecular dynamics data. Annals of Applied Statistics,

Molecular dynamics simulations produce huge datasets of temporal sequences of molecules. It is of interest to summarize the shape evolution of the molecules in a succinct, low-dimensional representation. However, Euclidean techniques such as principa... Read More

Localized induction of gene expression in embryonic stem cell aggregates using holographic optical tweezers to create biochemical gradients (2019)
Journal Article
Kirkham, G. R., Ware, J., Upton, T., Allen, S., Shakesheff, K. M., & Buttery, L. D. (in press). Localized induction of gene expression in embryonic stem cell aggregates using holographic optical tweezers to create biochemical gradients. Regenerative Engineering and Translational Medicine,

Three dimensional (3D) cell models that mimic the structure and function of native tissues are enabling more detailed study of physiological and pathological mechanisms in vitro. We have previously demonstrated the ability to build and manipulate 3D... Read More

In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs (2019)
Journal Article
Cingolani, E., Alqahtani, S., Sadler, R. C., Prime, D., Stolnik, S., & Bosquillon, C. (2019). In vitro investigation on the impact of airway mucus on drug dissolution and absorption at the air-epithelium interface in the lungs. European Journal of Pharmaceutics and Biopharmaceutics, 141, 210-220. doi:10.1016/j.ejpb.2019.05.022

Although the mucus layer is the first biological barrier encountered by inhaled drugs upon their deposition in the upper airways, its potential impact on drug dissolution and absorption in the lung has hardly been investigated. Bio-relevant in vitro... Read More

Proteins in Ionic Liquids: Reactions, Applications and Futures (2019)
Journal Article
Schindl, A., Hagen, M. L., Muzammal, S., Gunasekera, H. A., & Croft, A. K. (2019). Proteins in Ionic Liquids: Reactions, Applications and Futures. Frontiers in Chemistry, 7, doi:10.3389/fchem.2019.00347

Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given the increased solubility, and in some cases, structural stability imparted to these molecules. Focussing on proteins, we highlight here not just the key dri... Read More

Sparse Voltage Measurement-Based Fault Location Using Intelligent Electronic Devices (2019)
Journal Article
Jia, K., Yang, B., Dong, X., Feng, T., Bi, T., & Thomas, D. (2019). Sparse Voltage Measurement-Based Fault Location Using Intelligent Electronic Devices. IEEE Transactions on Smart Grid, 1-1. doi:10.1109/tsg.2019.2916819

This paper proposes a fault-section location method based on sparse measurements, aimed at asymmetrical faults. A virtual current vector is defined to indicate the faulted section, which is sufficiently sparse except that the fault position correspon... Read More

Multi-target design strategies for the improved treatment of Alzheimer's disease (2019)
Journal Article
Zhang, P., Xu, S., Zhu, Z., & Xu, J. (2019). Multi-target design strategies for the improved treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 176, 228-247. doi:10.1016/j.ejmech.2019.05.020

Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and poses a substantial burden on human health, economy, and society throughout the world. Based on the numerous AD-related targets in the disease network, multi-targe... Read More