Research Repository

See what's under the surface


A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs (2019)
Journal Article
Štaka, I., Cadete, A., Surikutchi, B. T., Abuzaid, H., Bradshaw, T. D., Alonso, M. J., & Marlow, M. (2019). A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs. International Journal of Pharmaceutics, doi:10.1016/j.ijpharm.2019.04.070

Herein, an injectable formulation composed of a low molecular weight gelator (LMWG) based hydrogel and drug-loaded polymeric nanocapsules (NCs) is described. The NCs, made of hyaluronic acid and polyglutamic acid and loaded with C14-Gemcitabine (GEM... Read More

Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form (2019)
Journal Article
Cader, H. K., Rance, G. A., Alexander, M. R., Gonçalves, A. D., Roberts, C. J., Tuck, C. J., & Wildman, R. D. (2019). Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form. International Journal of Pharmaceutics, 564, 359-368. doi:10.1016/j.ijpharm.2019.04.026

Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, i... Read More

Penetration and uptake of Nanoparticles in 3D tumour spheroids (2019)
Journal Article
Tchoryk, A., Taresco, V., Argent, R., Ashford, M. B., Gellert, P., Stolnik, S., …Garnett, M. C. (2019). Penetration and uptake of Nanoparticles in 3D tumour spheroids. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.9b00136

Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterised HCT116 colorectal cancer spheroids to study the effect of nanopa... Read More

A survey of smoking cessation training within UK Pharmacy education (2019)
Journal Article
Hunter, A., Bobak, A., & Anderson, C. (2019). A survey of smoking cessation training within UK Pharmacy education. Currents in Pharmacy Teaching and Learning, doi:10.1016/j.cptl.2019.03.007

Introduction: Tobacco smoking is a significant public health problem, and remains the leading cause of preventable, premature death in the UK. In order to reduce the burden of smoking in the UK, all healthcare professionals should be able to advise a... Read More

An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks (2019)
Journal Article
Belfield, K., Chen, X., Smith, E. F., Ashraf, W., & Bayston, R. (2019). An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks. Acta Biomaterialia, 90, 157-168. doi:10.1016/j.actbio.2019.03.042

Two major complications of indwelling urinary catheterisation include infection and mineral encrustation of the catheter. Our antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin has demonstrated long-term pro... Read More

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article
Pollard, A. K., Ingram, T. L., Ortori, C. A., Shephard, F., Brown, M., Liddell, S., …Chakrabarti, L. (2019). A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. Aging, doi:10.18632/aging.101861

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI (2019)
Journal Article
Li, C., Voos, K. M., Pathak, M., Hall, G., McCrae, K. R., Dreveny, I., …Emsley, J. (2019). Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. Journal of Thrombosis and Haemostasis, 17(5), 759-770. doi:10.1111/jth.14418

Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing serine proteases that when activated to PKa and FXIa cleave substrates kininogen, factor XII, and factor IX, respectively, directing plasma coagulation, bradykinin... Read More

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis (2019)
Journal Article
Ashraf, S., Radhi, M., Gowler, P., Burston, J. J., Gandhi, R. D., Thorn, G. J., …Chapman, V. (2019). The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Scientific Reports, 9, 1-17

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA... Read More

Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo (2019)
Journal Article
Francini, N., Cochrane, D., Illingworth, S., Purdie, L., Mantovani, G., Fisher, K., …Alexander, C. (2019). Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.9b00189

Oncolytic viruses offer many advantages for cancer therapy when administered directly to confined solid tumors. However, the systemic delivery of these viruses is problematic because of the host immune response, undesired interactions with blood comp... Read More

GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover (2019)
Journal Article
Garvin, A. J., Khalaf, A. H., Rettino, A., Xicluna, J., Butler, L., Morris, J. R., …Clarke, N. M. (2019). GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover. Nucleic Acids Research, 47(9), 4476-4494. doi:10.1093/nar/gkz163

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiqu... Read More

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples (2019)
Journal Article
Dooley, M., Prasopthum, A., Liao, Z., Sinjab, F., Mclaren, J., Rose, F. R. A. J., …Notingher, I. (2019). Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples. Biomedical Optics Express, 10(4), 1678-1690. doi:10.1364/BOE.10.001678

Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively the mineralization of bone tissue engineering scaffold in-vivo. The phantom samples consisted of 3D-printed s... Read More

Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC) (2019)
Journal Article
Ling, J. T. S., Roberts, C., & Billa, N. (2019). Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B 1 nanostructured lipid carrier (NLC). AAPS PharmSciTech, 20, doi:10.1208/s12249-019-1346-7

Surface - modified nanostructured lipid carriers (NLC) is a promising formulation to prolong the retention time of the therapeutic agent at the site of absorption. Chitosan-coated AmpB-loaded NLC (ChiAmpB NLC) were developed showing particle size of... Read More

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, doi:10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis (2019)
Journal Article
Zee, R. S., Mbanefo, E. C., Le, L. H., Pennington, L. F., Odegaard, J., Jardetzky, T. S., …Hsieh, M. H. (2019). IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis. AJP - Renal Physiology, doi:10.1152/ajprenal.00468.2018

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic adminis... Read More

1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding (2019)
Journal Article
Airhihen, B., Pavanello, L., Jadhav, G. P., Fischer, P. M., & Winkler, G. S. (2019). 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding. FEBS Open Bio, doi:10.1002/2211-5463.12605

In eukaryotic cells, cytoplasmic mRNA is characterised by a 3’ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation. Using recombinant... Read More

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. doi:10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors (2019)
Journal Article
Yao, H., Xu, F., Wang, G., Xie, S., Li, W., Yao, H., …Xu, S. (2019). Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. European Journal of Medicinal Chemistry, 167, 485-498. doi:10.1016/j.ejmech.2019.02.014

A series of novel B and C-rings truncated deguelin derivatives have been designed and synthesized in the present study as heat shock protein 90 (Hsp90) inhibitors. The synthesized compounds exhibited micromolar antiproliferative potency toward a pane... Read More

Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces (2019)
Journal Article
Sanjuan-Alberte, P., Saleh, E., Shaw, A. J., Lacalendola, N., Willmott, G., Vaithilingam, J., …Rawson, F. J. (2019). Remotely controlled in situ growth of silver microwires forming bioelectronic interfaces. ACS Applied Materials and Interfaces, 11(9), 8928-8936. doi:10.1021/acsami.8b22075

There is a pressing need to advance our ability to construct three-dimensional (3D) functional bioelectronic interfaces. Additionally, to ease the transition to building cellular electronic systems, a remote approach to merge electrical components wi... Read More

Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly (2019)
Journal Article
Di Palma, G., Kotowska, A. M., Hart, L. R., Scurr, D. J., Rawson, F. J., Tommasone, S., & Mendes, P. M. (2019). Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly. ACS Applied Materials and Interfaces, 11(9), 8937-8944. doi:10.1021/acsami.9b00927

The ability to design surfaces with reversible, high-affinity protein binding sites represents a significant step forward in the advancement of analytical methods for diverse biochemical and biomedical applications. Herein, we report a dynamic supram... Read More