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Nuclear poly(A) tail size is regulated by Cnot1 during the serum response (2019)
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Singhania, R., Thorn, G. J., Williams, K., Gandhi, R. D., Daher, C., Barthet-Barateig, A., …de Moor, C. H. (2019). Nuclear poly(A) tail size is regulated by Cnot1 during the serum response

The poly(A) tail removal from mRNAs introduces a delay between mRNA synthesis and decay. We measured levels and poly(A) tail sizes of serum-induced mRNAs and used mathematical modelling to compare their deadenylation time with the delay in decay and... Read More about Nuclear poly(A) tail size is regulated by Cnot1 during the serum response.

Gsmodutils: A python based framework for test-driven genome scale metabolic model development (2018)
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Gilbert, J. P., Pearcy, N., Norman, R., Millat, T., Winzer, K., King, J., …Twycross, J. (2018). Gsmodutils: A python based framework for test-driven genome scale metabolic model development

Motivation Genome scale metabolic models (GSMMs) are increasingly important for systems biology and metabolic engineering research as they are capable of simulating complex steady-state behaviour. Constraints based models of this form can include tho... Read More about Gsmodutils: A python based framework for test-driven genome scale metabolic model development.

Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models (2018)
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Ghosh, S., J. Gavaghan, D., & R. Mirams, G. Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models

Mathematical models of biological systems are beginning to be used for safety-critical applications, where large numbers of repeated model evaluations are required to perform uncertainty quantification and sensitivity analysis. Most of these models a... Read More about Gaussian process emulation for discontinuous response surfaces with applications for cardiac electrophysiology models.