Research Repository

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TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study (2019)
Journal Article
Ridd, M. J., Edwards, L., Santer, M., Chalmers, J. R., Waddell, L., Marriage, D., …Boyle, R. J. (2019). TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study. BMJ Open, 9, doi:10.1136/bmjopen-2018-028428

Background Early-onset eczema is associated with food allergy, and allergic reactions to foods can cause acute exacerbations of eczema. Parents often pursue dietary restrictions as a way of managing eczema and seek allergy testing for their childre... Read More

Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care (2019)
Journal Article
Weng, S., Kai, J., Akyea, R., & Qureshi, N. (2019). Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care. Lancet Public Health, 4(5), doi:10.1016/S2468-2667(19)30061-1

Background: The vast majority of individuals with familial hypercholesterolaemia (FH) in the general population remain unidentified worldwide. Recognising patients most at risk of having the condition, to enable targeted specialist assessment and tre... Read More

Understanding pathways to social inequalities in childhood unintentional injuries: findings from the UK Millennium Cohort Study (2019)
Journal Article
Campbell, M., Lai, E. T., Pearce, A., Orton, E., Kendrick, D., Wickham, S., & Taylor-Robinson, D. C. (in press). Understanding pathways to social inequalities in childhood unintentional injuries: findings from the UK Millennium Cohort Study. BMC Pediatrics,

Background: Childhood unintentional injuries (UI) are common but continue to happen more often to children living in less advantaged socioeconomic circumstances (SEC). Our aim was to explore how early life factors mediate the association between SEC... Read More

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, doi:10.1136/heartjnl-2018-314253

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More

A tailored digital behaviour change intervention with e-referral system to increase attendance at NHS Stop Smoking Services (The MyWay Project): study protocol for a randomised controlled feasibility trial (2019)
Journal Article
Fulton, E. A., Newby, K., Gokal, K., Kwah, K., Schumacher, L., Jackson, L. J., …Brown, K. E. (2019). A tailored digital behaviour change intervention with e-referral system to increase attendance at NHS Stop Smoking Services (The MyWay Project): study protocol for a randomised controlled feasibility trial. BMJ Open, 9, doi:10.1136/bmjopen-2018-028721

Introduction: In the UK, smokers who use Stop Smoking Services (SSS) are four times more likely to stop smoking than smokers who do not. Attendance has declined, warranting the development of interventions to address this. StopAppTM is a novel, bri... Read More

Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (2019)
Journal Article
Ing Lee, S., Patel, M., Dutton, B., Weng, S., Luveta, J., & Qureshi, N. (in press). Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review. Journal of Community Genetics,

This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary careto improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane l... Read More

Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches (2019)
Journal Article
Weng, S. F., Vaz, L., Qureshi, N., & Kai, J. (2019). Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches. PLoS ONE, 14(3), 1-22. doi:10.1371/journal.pone.0214365

Background: Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes of even greater complexity, such as premature death. This stud... Read More

Proactive assessment of obesity risk during infancy (ProAsk): a qualitative study of parents’ and professionals’ perspectives on an mHealth intervention. (2019)
Journal Article
Rose, J., Glazebrook, C., Wharrad, H., Siriwardena, A. N., Swift, J. A., Nathan, D., …Redsell, S. (2019). Proactive assessment of obesity risk during infancy (ProAsk): a qualitative study of parents’ and professionals’ perspectives on an mHealth intervention. BMC Public Health, 19, doi:10.1186/s12889-019-6616-5

Background: Prevention of childhood obesity is a public health priority. Interventions that establish healthy growth trajectories early in life promise lifelong benefits to health and wellbeing. Proactive Assessment of Obesity Risk during Infancy... Read More

A systematic review showing the lack of diagnostic criteria and tools developed for lower limb cellulitis (2019)
Journal Article
Patel, M., Lee, S. I., Akyea, R. K., Grindlay, D., Francis, N., Levell, N. J., …Thomas, K. (in press). A systematic review showing the lack of diagnostic criteria and tools developed for lower limb cellulitis. British Journal of Dermatology, doi:10.1111/bjd.17857

Background: Cellulitis can be a difficult diagnosis to make. 31% of patients admitted from the emergency department with suspected lower limb cellulitis are misdiagnoses, with incorrect treatment potentially resulting in avoidable hospital admission... Read More

Stop smoking practitioner consensus on barriers and facilitators to smoking cessation in pregnancy and how to address these: a modified Delphi survey (2019)
Journal Article
Fergie, L., Campbell, K., Coleman-Haynes, T., Ussher, M., Cooper, S., & Coleman, T. (2019). Stop smoking practitioner consensus on barriers and facilitators to smoking cessation in pregnancy and how to address these: a modified Delphi survey. Addictive Behaviors Reports, 9, doi:10.1016/j.abrep.2019.100164

Introduction: Pregnant women can experience barriers and facilitators towards achieving smoking cessation. We sought consensus from smoking cessation practitioners on how influential pre-identified barriers and facilitators can be on pregnant women'... Read More

Processing discharge summaries in general practice: a qualitative interview study with GPs and practice managers (2019)
Journal Article
Spencer, R. A., Rodgers, S., Salema, N., Campbell, S. M., & Avery, A. J. (2019). Processing discharge summaries in general practice: a qualitative interview study with GPs and practice managers. BJGP Open, 3(1), doi:10.3399/bjgpopen18X101625

Background Discharge summaries are essential for communicating patient information from secondary care to general practice on hospital discharge. Although there has been extensive research into their design and completion in secondary care very l... Read More

Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review (2019)
Journal Article
Zghebi, S. S., Panagioti, M., Rutter, M. K., Ashcroft, D. M., van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2019). Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review. Diabetic Medicine, doi:10.1111/dme.13905

Aims: To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods: We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data‐based diabetes‐sp... Read More

Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2019). Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 364, doi:10.1136/bmj.k4810

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy. Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More

Attitudes to E-Cigarettes and Cessation Support for Pregnant Women from English Stop Smoking Services: A Mixed Methods Study (2019)
Journal Article
Cooper, S., Orton, S., Campbell, K., Ussher, M., Coleman-Haynes, N., Whitemore, R., …Coleman, T. (2019). Attitudes to E-Cigarettes and Cessation Support for Pregnant Women from English Stop Smoking Services: A Mixed Methods Study. International Journal of Environmental Research and Public Health, 16(1), doi:10.3390/ijerph16010110

Smoking in pregnancy remains a public health problem. In the UK e-cigarettes are the most popular aid to quitting smoking outside of pregnancy, but we don’t know the extent of e-cigarette use in pregnancy or how English Stop Smoking Services (SSS) re... Read More

A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum (2018)
Journal Article
Brown, T. J., Hardeman, W., Bauld, L., Holland, R., Maskrey, V., Naughton, F., …Notley, C. (2019). A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum. Addictive Behaviors, 92, 236-243. doi:10.1016/j.addbeh.2018.12.031

Introduction: There is no routine support to prevent postpartum smoking relapse, due to lack of effective interventions. Previous reviews have identified behaviour change techniques (BCTs) within pregnancy cessation trials to specify which components... Read More

Healthcare utilisation, morbidities and alcohol use monitoring prior to alcoholic psychosis diagnosis (2018)
Journal Article
Otete, H., Fleming, K. M., West, J., & Orton, E. (2019). Healthcare utilisation, morbidities and alcohol use monitoring prior to alcoholic psychosis diagnosis. Alcohol and Alcoholism, 54(2), 131–138. doi:10.1093/alcalc/agy085

Aims: This study aimed to describe healthcare utilisation, morbidities and monitoring of alcohol use in patients prior to a diagnosis of alcoholic psychosis in order to inform the early identification of patients at risk. Method: Using linked gene... Read More

The relationship between patients’ illness beliefs and recovery after stroke (2018)
Journal Article
Aujla, N., Walker, M., Vedhara, K., & Sprigg, N. (2019). The relationship between patients’ illness beliefs and recovery after stroke. Psychology, Health and Medicine, 24(5), 551-558. doi:10.1080/13548506.2018.1557712

The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecti... Read More

Identifying effective behavior change techniques for alcohol and illicit substance use during pregnancy: a systematic review (2018)
Journal Article
Fergie, L., Cambbell, K., Coleman-Haynes, T., Ussher, M., Cooper, S., & Coleman, T. (2018). Identifying effective behavior change techniques for alcohol and illicit substance use during pregnancy: a systematic review. Annals of Behavioral Medicine, 1-13. doi:10.1093/abm/kay085

Background: During pregnancy, consuming alcohol and using illicit drugs can have serious health implications for both mother and child. Behavioral change interventions, especially those underpinned by theoretical constructs, can be effective in reduc... Read More

Developing a learning health system: insights from a qualitative process evaluation of a pharmacist-led electronic audit and feedback intervention to improve medication safety in primary care. (2018)
Journal Article
Jeffries, M., Keers, R. N., Phipps, D. L., Williams, R., Brown, B., Avery, A. J., …Ashcroft, D. M. (2018). Developing a learning health system: insights from a qualitative process evaluation of a pharmacist-led electronic audit and feedback intervention to improve medication safety in primary care. PLoS ONE, 13(10), doi:10.1371/journal.pone.0205419

Introduction: Developments in information technology offer opportunities to enhance medication safety in primary care. We evaluated the implementation and adoption of a complex pharmacist-led intervention involving the use of an electronic audit and... Read More

A dynamic, modifiable model for estimating cost-effectiveness of smoking cessation interventions in pregnancy: application to an RCT of self-help delivered by text message (2018)
Journal Article
Jones, M., Smith, M., Lewis, S., Parrott, S., & Coleman, T. (2019). A dynamic, modifiable model for estimating cost-effectiveness of smoking cessation interventions in pregnancy: application to an RCT of self-help delivered by text message. Addiction, 114(2), 353-365. doi:10.1111/add.14476

Background/Aims: Previous evaluations of smoking cessation interventions in pregnancy have several limitations. Our solution to these limitations is the Economics of Smoking in Pregnancy (ESIP) model which estimates the lifetime cost-effectiveness of... Read More