Research Repository

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Is it safe to vape whilst breastfeeding? Postpartum women's opinions on e-cigarettes, using online forum discussions: a qualitative analysis. (2019)
Journal Article
Johnston, E. J., Campbell, K., Coleman, T., Lewis, S., Orton, S., & Cooper, S. (2019). Is it safe to vape whilst breastfeeding? Postpartum women's opinions on e-cigarettes, using online forum discussions: a qualitative analysis. JMIR, 21(8), doi:10.2196/11506

Background: E-cigarettes are an increasingly popular alternative to smoking, helping to prevent relapse in those trying to quit, and with potential for harm reduction as they are likely to be safer than smoking. Many women return to smoking in the po... Read More

Mood and Influenza Vaccination in Older Adults: A Randomised Controlled Trial (2019)
Journal Article
Ayling, K., Fairclough, L., Buchanan, H., Wetherell, M. A., & Vedhara, K. (2019). Mood and Influenza Vaccination in Older Adults: A Randomised Controlled Trial. Health Psychology, doi:10.1037/hea0000786

Objective: Positive mood on the day of vaccination has been associated with subsequent antibody responses to the influenza vaccine in older adults. The primary aim of this trial was to examine whether a brief intervention was able to enhance positive... Read More

Unconditional and conditional monetary incentives to increase response to mailed questionnaires: a randomised controlled study within a trial (SWAT) (2019)
Journal Article
Young, B., Bedford, L., das Nair, R., Gallant, S., Littleford, R., Robertson, J. F., …ECLS Study Team, . (2019). Unconditional and conditional monetary incentives to increase response to mailed questionnaires: a randomised controlled study within a trial (SWAT). Journal of Evaluation in Clinical Practice, doi:10.1111/jep.13230

Rationale, aims, and objectives: High response rates to research questionnaires can help to ensure results are more representative of the population studied and provide increased statistical power, on which the study may have been predicated. Improvi... Read More

Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach (2019)
Journal Article
Cabral, C., Horwood, J., Symonds, J., Ingram, J., Lucas, P. J., Redmond, N. M., …Barnes, R. K. (2019). Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach. BMC Family Practice, 20(1), doi:10.1186/s12875-019-0993-9

Background: Acute respiratory tract infections (RTI) in children are a common reason for antibiotic prescribing. Clinicians’ prescribing decisions are influenced by perceived parental expectations for antibiotics, however there is evidence that paren... Read More

Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis (2019)
Journal Article
Panagioti, M., Khan, K., Keers, R. N., Abuzour, A., Phipps, D., Kontopantelis, E., …Ashcroft, D. M. (2019). Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ, 366, doi:10.1136/bmj.l4185

Objective: To systematically quantify the prevalence, severity, and nature of preventable patient harm across a range of medical settings globally. Design: Systematic review and meta-analysis. Data sources: Medline, PubMed, PsycINFO, Cinahl and... Read More

How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise (2019)
Journal Article
Salway, S., Yazici, E., Khan, N., Ali, P., Elmslie, F., Thompson, J., & Qureshi, N. (2019). How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise. BMJ Open, 9(7), doi:10.1136/bmjopen-2019-028928

Objectives: (1) To explore professional and lay stakeholder views on the design and delivery of services in the area of consanguinity and genetic risk. (2) To identify principles on which there is sufficient consensus to warrant inclusion in a nation... Read More

Is the apparently protective effect of maternal nicotine replacement therapy (NRT) used in pregnancy on infant development explained by smoking cessation?: secondary analyses of a randomised controlled trial. (2019)
Journal Article
Iyen, B., Vaz, L. R., Taggar, J., Cooper, S., Lewis, S., & Coleman, T. (2019). Is the apparently protective effect of maternal nicotine replacement therapy (NRT) used in pregnancy on infant development explained by smoking cessation?: secondary analyses of a randomised controlled trial. BMJ Open, 9(7), doi:10.1136/bmjopen-2018-024923

Objective: To investigate relationships between maternal smoking status in pregnancy and infant development. The largest RCT of nicotine replacement therapy (NRT) for smoking cessation in pregnancy, the Smoking and Nicotine in Pregnancy (SNAP) trial... Read More

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, doi:10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia. OBJECTIVE To assess associations between anticholinergic dr... Read More

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2019)
Journal Article
Swain, S., Sarmanova, A., Coupland, C., Doherty, M., & Zhang, W. (2019). Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies. Arthritis Care and Research, doi:10.1002/acr.24008

Objectives Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More

GPs’ views about their role when children and young people disclose a history of bullying in the community: a qualitative study (2019)
Journal Article
Prasad, V., & Condon, L. (2019). GPs’ views about their role when children and young people disclose a history of bullying in the community: a qualitative study. British Journal of General Practice, 69(Supplement 1), doi:10.3399/bjgp19x702953

Background Bullying among children and young people (CYP) can lead to both physical and mental health consequences. CYP may disclose episodes of bullying and seek help from their GP. Therefore GPs have an important role in dealing with the mental... Read More

Development of a Complex Intervention for the Maintenance of Postpartum Smoking Abstinence: Process for Defining Evidence-Based Intervention (2019)
Journal Article
Notley, C., Brown, T. J., Bauld, L., Hardeman, W., Holland, R., Naughton, F., …Ussher, M. (2019). Development of a Complex Intervention for the Maintenance of Postpartum Smoking Abstinence: Process for Defining Evidence-Based Intervention. International Journal of Environmental Research and Public Health, 16(11), doi:10.3390/ijerph16111968

Relapse to tobacco smoking for pregnant women who quit is a major public health problem. Evidence-based approaches to intervention are urgently required. This study aimed to develop an intervention to be integrated into existing healthcare. A mixed m... Read More

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Iyen, B., Qureshi, N., Leonardi-Bee, J., Kai, J., Akyea, R. K., Roderick, P., …Weng, S. (2019). Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study. Atherosclerosis, 287, 8-15. doi:10.1016/j.atherosclerosis.2019.05.017

Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More

Saliva cotinine concentrations in pregnant women who smoke and use nicotine patches (2019)
Journal Article
Claire, R., Coleman, T., Leonardi‐Bee, J., & Berlin, I. (2019). Saliva cotinine concentrations in pregnant women who smoke and use nicotine patches. Addiction, 114(9), 1651-1658. doi:10.1111/add.14662

Background and Aims: Due to concerns about increased exposure to nicotine, pregnant women using nicotine replacement therapy (NRT) to stop smoking are usually advised to stop using NRT if they relapse to smoking. This study investigated whether this... Read More

Understanding pathways to social inequalities in childhood unintentional injuries: findings from the UK Millennium Cohort Study (2019)
Journal Article
Campbell, M., Lai, E. T., Pearce, A., Orton, E., Kendrick, D., Wickham, S., & Taylor-Robinson, D. C. (2019). Understanding pathways to social inequalities in childhood unintentional injuries: findings from the UK Millennium Cohort Study. BMC Pediatrics, 19, doi:10.1186/s12887-019-1514-7

Background: Childhood unintentional injuries (UI) are common but continue to happen more often to children living in less advantaged socioeconomic circumstances (SEC). Our aim was to explore how early life factors mediate the association between SEC... Read More

TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study (2019)
Journal Article
Ridd, M. J., Edwards, L., Santer, M., Chalmers, J. R., Waddell, L., Marriage, D., …Boyle, R. J. (2019). TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study. BMJ Open, 9, doi:10.1136/bmjopen-2018-028428

Background Early-onset eczema is associated with food allergy, and allergic reactions to foods can cause acute exacerbations of eczema. Parents often pursue dietary restrictions as a way of managing eczema and seek allergy testing for their childre... Read More

Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (2019)
Journal Article
Ing Lee, S., Patel, M., Dutton, B., Weng, S., Luveta, J., & Qureshi, N. (2019). Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review. Journal of Community Genetics, doi:10.1007/s12687-019-00419-6

This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary careto improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane l... Read More

Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care (2019)
Journal Article
Weng, S., Kai, J., Akyea, R., & Qureshi, N. (2019). Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care. Lancet Public Health, 4(5), doi:10.1016/S2468-2667(19)30061-1

Background: The vast majority of individuals with familial hypercholesterolaemia (FH) in the general population remain unidentified worldwide. Recognising patients most at risk of having the condition, to enable targeted specialist assessment and tre... Read More

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, 105, 975-981. doi:10.1136/heartjnl-2018-314253

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More