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A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium (2012)
Journal Article
Safuan, S., Storr, S. J., Patel, P. M., & Martin, S. G. (2012). A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium. Lymphatic Research and Biology, 10(4), doi:10.1089/lrb.2012.0007

Background: Lymphovascular invasion (LVI) is an important step in the metastatic cascade; tumor cell migration and adhesion to blood and lymphatic vessels is followed by invasion through the vessel wall and subsequent systemic spread. Although prim... Read More about A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium.

Quorum-sensing and cheating in bacterial biofilms (2012)
Journal Article
Popat, R., Crusz, S. A., Messina, M., Willams, P., West, S. A., & Diggle, S. P. (2012). Quorum-sensing and cheating in bacterial biofilms. Proceedings of the Royal Society B: Biological Sciences, 279(1748), doi:10.1098/rspb.2012.1976

The idea from human societies that self-interest can lead to a breakdown of cooperation at the group level is sometimes termed the public goods dilemma. We tested this idea in the opportunistic bacterial pathogen, Pseudomonas aeruginosa, by examini... Read More about Quorum-sensing and cheating in bacterial biofilms.

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla (2012)
Journal Article
Storr, S. J., Zaitoun, A. M., Arora, A., Durrant, L. G., Lobo, D. N., Madhusudan, S., & Martin, S. G. (2012). Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla. BMC Cancer, 12(511), doi:10.1186/1471-2407-12-511

Background: Pancreatic cancer, including cancer of the ampulla of Vater and bile duct, is very aggressive and has a poor five year survival rate; improved methods of patient stratification are required. Methods: We assessed the expression of calpai... Read More about Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla.

Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer (2012)
Journal Article
Storr, S. J., Safuan, S., Woolston, C. M., Abdel-Fatah, T., Deen, S., Chan, S. Y., & Martin, S. G. (2012). Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. Journal of Cellular and Molecular Medicine, 16(10), doi:10.1111/j.1582-4934.2012.01559.x

Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy regimen and the ability to identify those patients at risk of developing resistance is of considera... Read More about Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.

Calpain system protein expression in basal-like and triple-negative invasive breast cancer (2012)
Journal Article
Storr, S. J., Lee, K., Woolston, C. M., Safuan, S., Green, A., Macmillan, R., …Martin, S. G. (2012). Calpain system protein expression in basal-like and triple-negative invasive breast cancer. Annals of Oncology, 23(9), doi:10.1093/annonc/mds176

Background: Basal-like and triple-negative breast tumours encompass an important clinical subgroup and biomarkers that can prognostically stratify these patients are required. Materials and methods: We investigated two breast cancer tissue microarr... Read More about Calpain system protein expression in basal-like and triple-negative invasive breast cancer.

Kin selection, quorum sensing and virulence in pathogenic bacteria (2012)
Journal Article
Rumbaugh, K. P., Trivedi, U., Watters, C., Burton-Chellew, M. N., Diggle, S. P., & West, S. A. (2012). Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B: Biological Sciences, 279(1742), doi:10.1098/rspb.2012.0843

Bacterial growth and virulence often depends upon the cooperative release of extracellular factors excreted in response to quorum sensing (QS).We carried out an in vivo selection experiment in mice to examine how QS evolves in response to variation... Read More about Kin selection, quorum sensing and virulence in pathogenic bacteria.

A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity (2012)
Journal Article
Luckett, J., Darch, O., Watters, C., AbuOun, M., Wright, V., Paredes-Osses, E., …Hardie, K. R. (2012). A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity. PLoS Pathogens, 8(8), doi:10.1371/journal.ppat.1002854

The opportunistic human pathogen, Pseudomonas aeruginosa, is a major cause of infections in chronic wounds, burns and the lungs of cystic fibrosis patients. The P. aeruginosa genome encodes at least three proteins exhibiting the characteristic three... Read More about A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), doi:10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy (2012)
Journal Article
Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), doi:10.3748/wjg.v18.i16.1915

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response. METHODS: Formalin-fixed human gastro-oesophageal cancers were... Read More about Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy.

Structural evidence that colicin a protein binds to a novel binding site of TolA protein in Escherichia coli periplasm (2012)
Journal Article
Li, C., Zhang, Y., Vankemmelbeke, M., Hecht, O., Aleanizy, F. S., Macdonald, C., …Penfold, C. N. (2012). Structural evidence that colicin a protein binds to a novel binding site of TolA protein in Escherichia coli periplasm. Journal of Biological Chemistry, 287(23), doi:10.1074/jbc.M112.342246

The Tol assembly of proteins is an interacting network of proteins located in the Escherichia coli cell envelope that transduces energy and contributes to cell integrity. TolA is central to this network linking the inner and outer membranes by intera... Read More about Structural evidence that colicin a protein binds to a novel binding site of TolA protein in Escherichia coli periplasm.

The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer (2012)
Journal Article
Woolston, C. M., Zhang, L., Storr, S. J., Al-Attar, A., Shehata, M., Ellis, I. O., …Martin, S. G. (in press). The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer. Modern Pathology, 25, doi:10.1038/modpathol.2012.60

Neoadjuvant chemotherapy has become the standard of care for locally advanced primary breast cancer. Anthracycline-based regimens have proven to be one of the most effective treatments in this setting. As certain cytotoxic antineoplastic agents, such... Read More about The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer.

The glycosylation pattern of common allergens: the recognition and uptake of Der p 1 by epithelial and dendritic cells is carbohydrate dependent (2012)
Journal Article
Al-Ghouleh, A., Johal, R., Sharquie, I. K., Emara, M., Harrington, H., Shakib, F., & Ghaemmaghami, A. M. (2012). The glycosylation pattern of common allergens: the recognition and uptake of Der p 1 by epithelial and dendritic cells is carbohydrate dependent. PLoS ONE, 7(3), doi:10.1371/journal.pone.0033929

Allergens are initiators of both innate and adaptive immune responses. They are recognised at the site of entry by epithelial and dendritic cells (DCs), both of which activate innate inflammatory circuits that can collectively induce Th2 immune respo... Read More about The glycosylation pattern of common allergens: the recognition and uptake of Der p 1 by epithelial and dendritic cells is carbohydrate dependent.

Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts (2012)
Journal Article
Heeg, D., Burns, D. A., Cartman, S. T., & Minton, N. P. (2012). Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts. PLoS ONE, 7(2), doi:10.1371/journal.pone.0032381

Clostridium difficile spores play a pivotal role in the transmission of infectious diarrhoea, but in order to cause disease spores must complete germination and return to vegetative cell growth. While the mechanisms of spore germination are well unde... Read More about Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts.

Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite (2012)
Journal Article
Emara, M., Royer, P., Mahdavi, J., Shakib, F., & Ghaemmaghami, A. M. (2012). Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. Journal of Biological Chemistry, 287(8), doi:10.1074/jbc.M111.312520

Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differenti... Read More about Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.

The role of genetics in pre-eclampsia and potential pharmacogenomic interventions (2012)
Journal Article
Williams, P. J., & Morgan, L. (2012). The role of genetics in pre-eclampsia and potential pharmacogenomic interventions. Pharmacogenomics and Personalized Medicine, 2012:5, doi:10.2147/PGPM.S23141

The pregnancy-specific condition pre-eclampsia not only affects the health of mother and baby during pregnancy but also has long-term consequences, increasing the chances of cardiovascular disease in later life. It is accepted that pre-eclampsia has... Read More about The role of genetics in pre-eclampsia and potential pharmacogenomic interventions.

Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker (2012)
Journal Article
Heap, J. T., Ehsaan, M., Cooksley, C. M., Ng, Y., Cartman, S. T., Winzer, K., & Minton, N. P. (2012). Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker. Nucleic Acids Research, 40(8), doi:10.1093/nar/gkr1321

Most bacteria can only be transformed with circular plasmids, so robust DNA integration methods for these rely upon selection of single-crossover clones followed by counter-selection of double-crossover clones. To overcome the limited availability of... Read More about Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker.

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia (2012)
Journal Article
Williams, P. J., Mistry, H. D., & Morgan, L. (2012). Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertension, 2(2), doi:10.1016/j.preghy.2011.12.001

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-α), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent tr... Read More about Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia.

Bursting the bubble on bacterial biofilms: a flow cell methodology (2012)
Journal Article
Crusz, S. A., Popat, R., Rybtke, M. T., Cámara, M., Givskov, M., Tolker-Nielsen, T., …Williams, P. (2012). Bursting the bubble on bacterial biofilms: a flow cell methodology. Biofouling, 28(8), doi:10.1080/08927014.2012.716044

The flow cell biofilm system is an important and widely used tool for the in vitro cultivation and evaluation of bacterial biofilms under hydrodynamic conditions of flow. This paper provides an introduction to the background and use of such systems,... Read More about Bursting the bubble on bacterial biofilms: a flow cell methodology.

Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma (2011)
Journal Article
Storr, S. J., Safuan, S., Mitra, A., Elliott, F., Walker, C., Vasko, M. J., …Martin, S. G. (2011). Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma. Modern Pathology, 25(4), doi:10.1038/modpathol.2011.182

The aims of this study were to investigate the role of vascular invasion (blood and lymphatic), vessel density and the presence of tumour-associated macrophages as prognostic markers in 202 cutaneous melanoma patients. Sections of primary melanoma we... Read More about Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article
Williams, P. J., & Broughton Pipkin, F. (2011). The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 25(4), doi:10.1016/j.bpobgyn.2011.02.007

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.