All Outputs (4)

The role of genetics in pre-eclampsia and potential pharmacogenomic interventions (2012)
Journal Article
Williams, P. J., & Morgan, L. (2012). The role of genetics in pre-eclampsia and potential pharmacogenomic interventions. Pharmacogenomics and Personalized Medicine, 2012:5, https://doi.org/10.2147/PGPM.S23141

The pregnancy-specific condition pre-eclampsia not only affects the health of mother and baby during pregnancy but also has long-term consequences, increasing the chances of cardiovascular disease in later life. It is accepted that pre-eclampsia has... Read More about The role of genetics in pre-eclampsia and potential pharmacogenomic interventions.

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia (2012)
Journal Article
Williams, P. J., Mistry, H. D., & Morgan, L. (2012). Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertension, 2(2), https://doi.org/10.1016/j.preghy.2011.12.001

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-?), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent tr... Read More about Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article
Williams, P. J., & Broughton Pipkin, F. (2011). The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 25(4), https://doi.org/10.1016/j.bpobgyn.2011.02.007

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy (2011)
Journal Article
Williams, P. J., Bulmer, J. N., Innes, B. A., & Broughton Pipkin, F. (2011). Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biology of Reproduction, 84(6), https://doi.org/10.1095/biolreprod.110.088351

In addition to its role in the prevention of neural tube defects, folic acid has many other physiological functions, including cell proliferation, DNA replication, and antioxidant protection. The aim of this study was to determine the role that folic... Read More about Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy.