Research Repository

See what's under the surface

Browse


Development of lipopolyplexes for gene delivery: a comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes (2018)
Journal Article
Bofinger, R., Zaw-Thin, M., Mitchell, N. J., Patrick, P. S., Stowe, C., Gomez-Ramirez, A., …Tabor, A. B. (2018). Development of lipopolyplexes for gene delivery: a comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes. Journal of Peptide Science, (e3131). doi:10.1002/psc.3131. ISSN 1075-2617

The design, synthesis and formulation of non‐viral gene delivery vectors is an area of renewed research interest. Amongst the most efficient non‐viral gene delivery systems are lipopolyplexes, in which cationic peptides are co‐formulated with plasmid... Read More

Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols (2018)
Journal Article
Panchal, H., Clarke, C., Bell, C., Karad, S. N., Lewis, W., & Lam, H. W. (2018). Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols. Chemical Communications, 54(87), 12389-12392. doi:10.1039/c8cc06388e

Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to g... Read More

Biocatalytic N-acylation of amines in water using an acyltransferase from Mycobacterium smegmatis (2018)
Journal Article
Contente, M., Pinto, A., Molinari, F., & Paradisi, F. (2018). Biocatalytic N-acylation of amines in water using an acyltransferase from Mycobacterium smegmatis. Advanced Synthesis and Catalysis, doi:10.1002/adsc.201801061. ISSN 1615-4150

A straightforward one-step biocatalyzed synthesis of different N-acyl amides in water was accomplished using the versatile and chemoselective acyltransferase from Mycobacterium smegmatis (MsAcT). Acetylation of primary arylalkyl amines was achieved w... Read More

Ion - reagent interactions contributing to ionic liquid solvent effects on a condensation reaction (2018)
Journal Article
Keaveney, S. T., Harper, J. B., & Croft, A. K. (2018). Ion - reagent interactions contributing to ionic liquid solvent effects on a condensation reaction. ChemPhysChem, doi:10.1002/cphc.201800695

Molecular dynamics simulations of solutions of hexan-1-amine or 4-methoxybenzaldehyde in acetonitrile, an ionic liquid/ acetonitrile mixture (XIL = 0.2), and a number of different (neat) ionic liquids were performed, to further understand the solvent... Read More

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art (2018)
Journal Article
Beddoe, R. H., Sneddon, H. F., & Denton, R. M. (2018). The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art. Organic and Biomolecular Chemistry, 42(16), 7774-7781. doi:10.1039/c8ob01929k

The Mitsunobu reaction is widely regarded as the pre-eminent method for performing nucleophilic substitutions of alcohols with inversion of configuration. However, its applicability to large-scale synthesis is undermined by the fact that alcohol acti... Read More

Synthesis of multisubstituted pyrroles by nickel-catalyzed arylative cyclizations of N-tosyl alkynamides (2018)
Journal Article
Gillbard, S. M., Chung, C., Karad, S. N., Panchal, H., Lewis, W., & Lam, H. W. (2018). Synthesis of multisubstituted pyrroles by nickel-catalyzed arylative cyclizations of N-tosyl alkynamides. Chemical Communications, 54(83), 11769-11772. doi:10.1039/c8cc06649c

The synthesis of multisubstituted pyrroles by the nickel-catalyzed reaction of N-tosylalkynamides with arylboronic acids is reported. These reactions are triggered by alkyne arylnickelation, followed by cyclization of the resulting alkenylnickel spec... Read More

Construction of challenging proline–proline junctions via diselenide–selenoester ligation chemistry (2018)
Journal Article
Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., …Payne, R. J. (2018). Construction of challenging proline–proline junctions via diselenide–selenoester ligation chemistry. Journal of the American Chemical Society, 140(41), (13327-13334). doi:10.1021/jacs.8b07877. ISSN 0002-7863

Polyproline sequences are highly abundant in prokaryotic 10 and eukaryotic proteins, where they serve as key components of 11 secondary structure. To date, construction of the proline−proline motif 12 has not been possible owing to steric congestion... Read More

Self-sufficient flow-biocatalysis by coimmobilization of pyridoxal 5′-phosphate and ω-transaminases onto porous carriers (2018)
Journal Article
Benítez-Mateos, A. I., Contente, M. L., Velasco-Lozano, S., Paradisi, F., & López-Gallego, F. (2018). Self-sufficient flow-biocatalysis by coimmobilization of pyridoxal 5′-phosphate and ω-transaminases onto porous carriers. ACS Sustainable Chemistry and Engineering, 6(10), (13151-13159). doi:10.1021/acssuschemeng.8b02672. ISSN 2168-0485

We expanded the application of self-sufficient heterogeneous biocatalysts containing coimmobilized w-transaminases and pyridoxal 5´-phosphate (PLP) to efficiently operate packed-bed reactors in continuous flow. Using a w-transaminase from Halomonas e... Read More

Origin of the thiopyrone CTP-431 “unexpectedly” isolated from the marine sponge Cacospongia mycofijiensis (2018)
Journal Article
Przeslak, A. D., Inman, M., Lewis, W., & Moody, C. J. (2018). Origin of the thiopyrone CTP-431 “unexpectedly” isolated from the marine sponge Cacospongia mycofijiensis. Journal of Organic Chemistry, 83(17), (10595-10601). doi:10.1021/acs.joc.8b01258. ISSN 0022-3263

An intriguing hypothesis that latrunculin A, a well-known natural product, might have undergone transformation into the unprecedented thiopyrone CTP-431 upon long-term storage in methanol is advanced. Thus opening of the hemiacetal of latrunculin A,... Read More