All Outputs (3)

Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click (2020)
Journal Article
Harvey, D., Bray, G., Zamberlan, F., Amer, M., Goodacre, S. L., & Thomas, N. R. (2020). Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click. Macromolecular Bioscience, https://doi.org/10.1002/mabi.202000255

Recombinant spider silk has the potential to provide a new generation of biomaterial scaffolds as a result of its degree of biocompatibility and lack of immunogenicity. These recombinant biomaterials are, however, reported to exhibit poor cellular ad... Read More about Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click.

Conservation of a pH-sensitive structure in the C-terminal region of spider silk extends across the entire silk gene family (2018)
Journal Article
Strickland, M., Tudorica, V., Řezáč, M., Thomas, N. R., & Goodacre, S. L. (2018). Conservation of a pH-sensitive structure in the C-terminal region of spider silk extends across the entire silk gene family. Heredity, 120(6), 574-580. https://doi.org/10.1038/s41437-018-0050-9

Spiders produce multiple silks with different physical properties that allow them to occupy a diverse range of ecological niches, including the underwater environment. Despite this functional diversity, past molecular analyses show a high degree of a... Read More about Conservation of a pH-sensitive structure in the C-terminal region of spider silk extends across the entire silk gene family.

Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry (2016)
Journal Article
Harvey, D., Bardelang, P., Goodacre, S. L., Cockayne, A., & Thomas, N. R. (2017). Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry. Advanced Materials, 29(10), 1-5. https://doi.org/10.1002/adma.201604245

The use of functionalised recombinant spider silk as a sustainable advanced biomaterial is currently an area of intense interest owing to spider silk’s intrinsic strength, toughness, biocompatibility and biodegradability. This paper demonstrates, for... Read More about Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry.