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Phosphine and Selenoether peri-Substituted Acenaphthenes and Their Transition-Metal Complexes: Structural and NMR Investigations (2023)
Journal Article
Zhang, L., Christie, F. A., Tarcza, A. E., Lancaster, H. G., Taylor, L. J., Bühl, M., …Kilian, P. (2023). Phosphine and Selenoether peri-Substituted Acenaphthenes and Their Transition-Metal Complexes: Structural and NMR Investigations. Inorganic Chemistry, 62(39), 16084–16100. https://doi.org/10.1021/acs.inorgchem.3c02255

A series of -substituted acenaphthene-based phosphine selenoether bidentate ligands Acenap( Pr P)(SeAr) ( - , Acenap = acenaphthene-5,6-diyl, Ar = Ph, mesityl, 2,4,6-trisopropylphenyl and supermesityl) were prepared. The rigid acenaphthene framework... Read More about Phosphine and Selenoether peri-Substituted Acenaphthenes and Their Transition-Metal Complexes: Structural and NMR Investigations.

Homogeneous Carbon Monoxide Homologation (2023)
Book Chapter
Geer, A. M., Kays, D. L., & Taylor, L. J. (2023). Homogeneous Carbon Monoxide Homologation. In Homologation Reactions: Reagents, Applications, and Mechanisms (831-846). Wiley. https://doi.org/10.1002/9783527830237.ch23

The homogeneous activation and homologation of carbon monoxide remains a challenging and highly attractive area of chemical research. This is due in part to the fundamental synthetic interest of using highly reactive complexes, spanning the full brea... Read More about Homogeneous Carbon Monoxide Homologation.

The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations (2023)
Journal Article
Musa, A., Ihmaid, S. K., Hughes, D. L., Said, M. A., Abulkhair, H. S., El-Ghorab, A. H., …El-Agrody, A. M. (2023). The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations. Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2023.2167000

Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggests that epid... Read More about The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.

Slow magnetic relaxation in Fe(ii) m-terphenyl complexes (2022)
Journal Article
Valentine, A. J., Geer, A. M., Blundell, T. J., Tovey, W., Cliffe, M. J., Davies, E. S., …Kays, D. L. (2022). Slow magnetic relaxation in Fe(ii) m-terphenyl complexes. Dalton Transactions, 51(47), 18118-18126. https://doi.org/10.1039/d2dt03531f

Two-coordinate transition metal complexes are exciting candidates for single-molecule magnets (SMMs) because their highly axial coordination environments lead to sizeable magnetic anisotropy. We report a series of five structurally related two-coordi... Read More about Slow magnetic relaxation in Fe(ii) m-terphenyl complexes.

Organoruthenium Complexes Containing Hemilabile Phosphinodicarboxamide Ligands (2022)
Working Paper
Nolla-Saltiel, R., Geer, A. M., Sharpe, H. R., Huke, C. D., Taylor, L. J., Linford-Wood, T. G., …Kays, D. L. Organoruthenium Complexes Containing Hemilabile Phosphinodicarboxamide Ligands

Ruthenium complexes of hemilabile phosphinocarboxamide ligands, and their use to form metallacycles using halide abstraction/deprotonation reactions are reported. Thus, [Ru(p-cym){PPh2C(=O)NHR}Cl2; R = iPr (1), Ph (2), p-tol (3)] and [Ru(p-cym){PPh2C... Read More about Organoruthenium Complexes Containing Hemilabile Phosphinodicarboxamide Ligands.

Structural and Electronic Studies of Substituted m-Terphenyl Group 12 Complexes (2022)
Journal Article
Valentine, A. J., Taylor, L. J., Geer, A. M., Huke, C. D., Wood, K. E., Tovey, W., …Kays, D. L. (2022). Structural and Electronic Studies of Substituted m-Terphenyl Group 12 Complexes. Organometallics, 41(11), 1426-1433. https://doi.org/10.1021/acs.organomet.2c00156

The effects of para-substitution on the structural and electronic properties of four series of two-coordinate m-terphenyl Group 12 complexes (R-Ar#)2M (M = Zn, Cd, Hg; R = t-Bu 1-3, SiMe34-6, Cl 7-9, CF310-12, where R-Ar#= 2,6-{2,6-Xyl}2-4-R-C6H2and... Read More about Structural and Electronic Studies of Substituted m-Terphenyl Group 12 Complexes.

Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions (2021)
Journal Article
Huke, C. D., Taylor, L. J., Argent, S. P., & Kays, D. L. (2021). Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions. ACS Sustainable Chemistry and Engineering, 9(32), 10704-10709. https://doi.org/10.1021/acssuschemeng.1c02907

A catalyst-free, low-solvent method for the hydrophosphinylation of isocyanates and isothiocyanates is reported. A range of phosphorus nucleophiles including secondary phosphine oxides HP(O)R2 (R = Ph, iPr), phosphites HP(O)(OR)2 (R = Me, Et), and me... Read More about Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions.

Group 11 m-Terphenyl Complexes Featuring Metallophilic Interactions (2021)
Journal Article
Liu, Y., Taylor, L. J., Argent, S. P., McMaster, J., & Kays, D. L. (2021). Group 11 m-Terphenyl Complexes Featuring Metallophilic Interactions. Inorganic Chemistry, 60(14), 10114-10123. https://doi.org/10.1021/acs.inorgchem.0c03623

A series of group 11 m-terphenyl complexes have been synthesized via a metathesis reaction from the iron(II) complexes (2,6-Mes2C6H3)2Fe and (2,6-Xyl2C6H3)2Fe (Mes = 2,4,6-Me3C6H2; Xyl = 2,6-Me2C6H3). [2,6-Mes2C6H3M]2 (1, M = Cu; 2, M = Ag; 6, M = Au... Read More about Group 11 m-Terphenyl Complexes Featuring Metallophilic Interactions.

Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process (2021)
Journal Article
Wu, L., Abreu, B. L., Blake, A. J., Taylor, L. J., Lewis, W., Argent, S. P., …George, M. W. (2021). Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process. Organic Process Research and Development, 25(8), 1873-1881. https://doi.org/10.1021/acs.oprd.1c00111

Photochemical synthesis of highly reactive hydroperoxides and their conversion into useful products, such as 1,2,4-trioxanes, are of wide interest for synthetic organic chemistry and pharmaceutical manufacturing particularly because of their relevanc... Read More about Multigram Synthesis of Trioxanes Enabled by a Supercritical CO2 Integrated Flow Process.

Structural and electronic studies of substituted m-terphenyl lithium complexes (2020)
Journal Article
Valentine, A. J., Geer, A. M., Taylor, L. J., Teale, A. M., Wood, K. E., Williams, H. E. L., …Kays, D. L. (2021). Structural and electronic studies of substituted m-terphenyl lithium complexes. Dalton Transactions, 50(2), 722-728. https://doi.org/10.1039/d0dt03972a

The effect of para-substitution upon the structural and electronic properties of a series of m-terphenyl lithium complexes [R-Ar#-Li]2 (R = t-Bu 1, SiMe32, H 3, Cl 4, CF35; where R-Ar# = 2,6-{2,6-Xyl}2-4-R-C6H2 and 2,6-Xyl = 2,6-Me2C6H3) has been inv... Read More about Structural and electronic studies of substituted m-terphenyl lithium complexes.

A transition metal–gallium cluster formed via insertion of “GaI” (2020)
Journal Article
Blundell, T. J., Taylor, L. J., Valentine, A. J., Lewis, W., Blake, A. J., McMaster, J., & Kays, D. L. (2020). A transition metal–gallium cluster formed via insertion of “GaI”. Chemical Communications, 56(58), 8139-8142. https://doi.org/10.1039/d0cc03559a

The reaction between a two-coordinate Co(II) diaryl complex and “GaI” affords 2,6-Pmp2C6H3CoGa3I5, in a new geometry for a heavier group 13-transition metal cluster. Experimental and computational investigations show that this compound is best descri... Read More about A transition metal–gallium cluster formed via insertion of “GaI”.

Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration (2020)
Journal Article
Groves, A., Sun, J., Parke, H. R. I., Callingham, M., Argent, S. P., Taylor, L. J., & Lam, H. W. (2020). Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration. Chemical Science, 11(10), 2759–2764. https://doi.org/10.1039/c9sc06309a

The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(I)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition–cyclization reactions is an alken... Read More about Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration.

Iron(II)-catalyzed hydroamination of isocyanates (2019)
Journal Article
South, A. J., Geer, A. M., Taylor, L. J., Sharpe, H. R., Lewis, W., Blake, A. J., & Kays, D. L. (2019). Iron(II)-catalyzed hydroamination of isocyanates. Organometallics, 38(21), 4115-4120. https://doi.org/10.1021/acs.organomet.9b00393

A two-coordinate Fe(II) m-terphenyl complex acts as a precatalyst for the hydroamination of isocyanates, affording urea and biuret derivatives, with product selectivity accomplished via modification of the reaction conditions. Using a more nucleophil... Read More about Iron(II)-catalyzed hydroamination of isocyanates.

Low-coordinate first-row transition metal complexes in catalysis and small molecule activation (2019)
Journal Article
Taylor, L. J., & Kays, D. L. (2019). Low-coordinate first-row transition metal complexes in catalysis and small molecule activation. Dalton Transactions, 48(33), 12365-12381. https://doi.org/10.1039/C9DT02402F

Enforcing unusually low coordination numbers on transition metals with sterically demanding ligands has long been an area of interest for chemists. Historically, the synthesis of these challenging molecules has helped to elucidate fundamental princip... Read More about Low-coordinate first-row transition metal complexes in catalysis and small molecule activation.

A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies (2019)
Journal Article
Ried, A., Taylor, L., Geer, A., Williams, H., Lewis, W., Blake, A., & Kays, D. L. (2019). A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies. Chemistry - A European Journal, 25(27), 6840-6846. https://doi.org/10.1002/chem.201901197

A magnesium complex (1) featuring a bidentate aminopyridinato ligand is a remarkably selective catalyst for the dehydrocoupling of amine-boranes. This reaction proceeds to completion with low catalyst loadings (1 mol%) und... Read More about A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies.

Selective reduction and homologation of carbon monoxide by organometallic iron complexes (2018)
Journal Article
Sharpe, H. R., Geer, A. M., Taylor, L. J., Gridley, B. M., Blundell, T. J., Blake, A. J., …Kays, D. L. (2018). Selective reduction and homologation of carbon monoxide by organometallic iron complexes. Nature Communications, 9, Article 3757. https://doi.org/10.1038/s41467-018-06242-w

Carbon monoxide is a key C1 feedstock for the industrial production of hydrocarbons, where it is used to make millions of tonnes of chemicals, fuels, and solvents per annum. Many transition metal complexes can coordinate CO2 but the formation of new... Read More about Selective reduction and homologation of carbon monoxide by organometallic iron complexes.

Dealkanative Main Group Couplings across the peri-Gap (2017)
Journal Article
Taylor, L. J., Bühl, M., Chalmers, B. A., Ray, M. J., Wawrzyniak, P., Walton, J. C., …Kilian, P. (2017). Dealkanative Main Group Couplings across the peri-Gap. Journal of the American Chemical Society, 139(51), 18545-18551. https://doi.org/10.1021/jacs.7b08682

Here, we highlight the ability of peri-substitution chemistry to promote a series of unique P-P/P-As coupling reactions, which proceed with concomitant C-H bond formation. This dealkanative reactivity represents an interesting and unexpected expansio... Read More about Dealkanative Main Group Couplings across the peri-Gap.

Optimised synthesis and characterisation of 1-adamantyltrimethylphosphonium iodide (2017)
Journal Article
Mansour, R., Nejman, P. S., Taylor, L. J., Chalmers, B. A., Rey, F., Bengueddach, A., …Kilian, P. (2017). Optimised synthesis and characterisation of 1-adamantyltrimethylphosphonium iodide. Polyhedron, 133, 302-306. https://doi.org/10.1016/j.poly.2017.05.050

A synthetic route to multigram quantities of 1-adamantyltrimethylphosphonium iodide is reported. The synthesis starts from the commercially available precursor 1-adamantyl bromide and was optimised with respect to yield and ease of purification. The... Read More about Optimised synthesis and characterisation of 1-adamantyltrimethylphosphonium iodide.

Hydride Abstraction and Deprotonation - an Efficient Route to Low Coordinate Phosphorus and Arsenic Species (2015)
Journal Article
Taylor, L. J., Bühl, M., Wawrzyniak, P., Chalmers, B. A., Woollins, J. D., Slawin, A. M., …Kilian, P. (2016). Hydride Abstraction and Deprotonation - an Efficient Route to Low Coordinate Phosphorus and Arsenic Species. European Journal of Inorganic Chemistry, 2016(5), 659-666. https://doi.org/10.1002/ejic.201500948

Treatment of Acenap(PiPr2)(EH2) (Acenap = acenaphthene-5,6-diyl; 1a, E = As; 1b, E = P) with Ph3C·BF4 resulted in hydride abstraction to give [Acenap(PiPr2)(EH)][BF4] (2a, E = As; 2b, E = P). These represent the first structurally characterised phosp... Read More about Hydride Abstraction and Deprotonation - an Efficient Route to Low Coordinate Phosphorus and Arsenic Species.