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Alcohol Dehydrogenase?triggered Oxa?Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans (2019)
Journal Article
Eastman, H., Ryan, J., Maciá, B., Caprio, V., & O'Reilly, E. (2019). Alcohol Dehydrogenase‐triggered Oxa‐Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans. ChemCatChem, 11(16), 3760-3762. https://doi.org/10.1002/cctc.201900658

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An alcohol dehydrogenase-mediated asymmetric reduction and subsequent intramolecular oxa-Michael reaction has been developed for the preparation of tetrahydropyrans (or oxanes) and tetrahydrofurans,... Read More about Alcohol Dehydrogenase?triggered Oxa?Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans.

Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations (2018)
Journal Article
Gomm, A., Grigoriou, S., Peel, C., Ryan, J., Mujtaba, N., Clarke, T., …O'Reilly, E. (2018). Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry, 2018(38), 5282-5284. https://doi.org/10.1002/ejoc.201800799

The 'smart' amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using the commercially available amine transaminase, ATA256. Th... Read More about Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations.

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds (2016)
Journal Article
Ryan, J., Šiaučiulis, M., Gomm, A., Macia, B., O'Reilly, E., & Caprio, V. (in press). Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds. Journal of the American Chemical Society, 138(49), https://doi.org/10.1021/jacs.6b07024

The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step into the synthesis. Herein, we describe a general biocatalytic approach for the enantioselectiv... Read More about Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds.