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m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination (2016)
Journal Article
Haussmann, I. U., Bodi, Z., Sanchez-Moran, E., Mongan, N. P., Archer, N., Fray, R. G., & Soller, M. (2016). m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature, 540(7632), doi:10.1038/nature20577. ISSN 0028-0836

N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7. The mammalian mRNA m6A methylosome is a complex of nuclear proteins that includes METTL3 (m... Read More

Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment (2015)
Journal Article
Bodi, Z., Bottley, A., Archer, N., May, S., & Fray, R. G. (2015). Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment. PLoS ONE, 10, doi:10.1371/journal.pone.0132090. ISSN 1932-6203

Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity-... Read More

Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects (2012)
Journal Article
Bodi, Z., Zhong, S., Mehra, S., Song, J., Graham, N., Li, H., …Fray, R. G. (2012). Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects. Frontiers in Plant Science, 3(48), doi:10.3389/fpls.2012.00048. ISSN 1664-462X

We previously showed that the N6-methyladenosine (m6A) mRNA methylase is essential during Arabidopsis thaliana embryonic development. We also demonstrated that this modification is present at varying levels in all mature tissues. However, the require... Read More