Skip to main content

Research Repository

Advanced Search

All Outputs (11)

Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications (2019)
Journal Article
Matamoros-Veloza, A., Hossain, K. M. Z., Scammell, B. E., Ahmed, I., Hall, R., & Kapur, N. (2020). Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications. Journal of the Mechanical Behavior of Biomedical Materials, 102, Article 103489. https://doi.org/10.1016/j.jmbbm.2019.103489

Current trends in regenerative medicine treatments for bone repair applications focus on cell-based therapies. These aim to deliver the treatment via a minimally invasive injection to reduce patient trauma and to improve efficacy. This paper describe... Read More about Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications.

The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glasses (2019)
Journal Article
Islam, M. T., Sharmin, N., Rance, G. A., Titman, J. J., Parsons, A. J., Hossain, K. M. Z., & Ahmed, I. (2020). The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glasses. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(3), 674-686. https://doi.org/10.1002/jbm.b.34421

Varying formulations in the glass system of 40P2O5─(24 − x)MgO─(16 + x)CaO─(20 − y)Na2O─yTiO2 (where 0 ≤ x ≤ 22 and y = 0 or 1) were prepared via melt-quenching. The structure of the glasses was confirmed by X-ray diffraction (XRD), Fourier transform... Read More about The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glasses.

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. https://doi.org/10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More about Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model.

In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration (2019)
Journal Article
Patel, U., Macri-Pellizzeri, L., Hossain, K. M. Z., Scammell, B. E., Grant, D. M., Scotchford, C. A., …Sottile, V. (2019). In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(3), 396-405. https://doi.org/10.1002/term.2796

Phosphate glasses (PBG) are ideal materials for regenerative medicine strategies since their composition, degradation rates and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorptio... Read More about In vitro cellular testing of Strontium/Calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration.

Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends (2018)
Journal Article
Felfel, R. M., Gideon-Adeniyi, M. J., Hossain, K. M. Z., Roberts, G. A., & Grant, D. M. (2019). Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends. Carbohydrate Polymers, 204, 59-67. https://doi.org/10.1016/j.carbpol.2018.10.002

This study aimed to explore the correlation between mechanical and structural properties of chitosan-agarose blend (Ch-Agrs) scaffolds. Porosity of Ch-Agrs scaffolds was constant at 93%, whilst pore sizes varied between 150 and 550 μm. Pore sizes of... Read More about Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends.

Flexible and transparent films produced from cellulose nanowhisker reinforced agarose (2018)
Journal Article
Felfel, R. M., Hossain, K. M. Z., Kabir, S. F., Yee, S. L., Ahmed, I., & Grant, D. M. (2018). Flexible and transparent films produced from cellulose nanowhisker reinforced agarose. Carbohydrate Polymers, 194, https://doi.org/10.1016/j.carbpol.2018.04.005

Transparent and flexible nanocomposite films with a range of Agarose to Cellulose Nano-Whisker (CNW) ratios were produced using never-dried CNWs. The incorporation of never-dried CNWs within Agarose played an important role in the surface roughness (... Read More about Flexible and transparent films produced from cellulose nanowhisker reinforced agarose.

Porous calcium phosphate glass microspheres for orthobiologic applications (2018)
Journal Article
Hossain, K. M. Z., Patel, U., Kennedy, A. R., Macri-Pellizzeri, L., Sottile, V., Grant, D. M., …Ahmed, I. (2018). Porous calcium phosphate glass microspheres for orthobiologic applications. Acta Biomaterialia, 72, 396-406. https://doi.org/10.1016/j.actbio.2018.03.040

© 2018 Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for producti... Read More about Porous calcium phosphate glass microspheres for orthobiologic applications.

Single solvent based film casting method for the production of porous polymer films (2018)
Journal Article
Hossain, K. M. Z., Felfel, R. M., Ogbilikana, P. S., Thakker, D., Grant, D. M., Scotchford, C., & Ahmed, I. (2018). Single solvent based film casting method for the production of porous polymer films. Macromolecular Materials and Engineering, 303, https://doi.org/10.1002/mame.201700628

A single solvent based film casting process for fabricating porous polymer films was developed in this study. The porous film was produced by mixing concentrated polylactic acid/ chloroform solution (20 wt%) and fresh chloroform solvent followed by f... Read More about Single solvent based film casting method for the production of porous polymer films.

Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation (2017)
Journal Article
Gupta, D., Grant, D. M., Hossain, K. M. Z., Ahmed, I., & Sottile, V. (2018). Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation. Journal of Biomaterials Applications, 32(7), https://doi.org/10.1177/0885328217745699

Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affec... Read More about Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.

Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications (2017)
Journal Article
Patel, U., Moss, R., Hossain, K., Kennedy, A., Barney, E., Ahmed, I., & Hannon, A. (2017). Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications. Acta Biomaterialia, 60, 109-127. https://doi.org/10.1016/j.actbio.2017.07.002

Neutron diffraction, 23Na and 31P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P2O5·(16 x)CaO·20Na2O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The 31P solid-state NMR r... Read More about Structural and physico-chemical analysis of calcium/ strontium substituted, near-invert phosphate based glasses for biomedical applications.

Structural, thermal, in vitro degradation and cytocompatibility properties of P2O5-B2O3-CaO-MgO-Na2O-Fe2O3 glasses (2016)
Journal Article
Zhu, C., Ahmed, I., Parsons, A., Hossain, K. M. Z., Rudd, C. D., Liu, J., & Liu, X. (2017). Structural, thermal, in vitro degradation and cytocompatibility properties of P2O5-B2O3-CaO-MgO-Na2O-Fe2O3 glasses. Journal of Non-Crystalline Solids, 457, https://doi.org/10.1016/j.jnoncrysol.2016.11.001

Borophosphate glasses with compositions of (48 ? x)P2O5-(12 + x)B2O3-14CaO-20MgO-1Na2O-5Fe2O3 (where x = 0, 3, 8 mol%) were prepared via a melt-quenching process. The effects of replacing P2O5 with B2O3 on the structural, thermal, degradation propert... Read More about Structural, thermal, in vitro degradation and cytocompatibility properties of P2O5-B2O3-CaO-MgO-Na2O-Fe2O3 glasses.