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UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery (2017)
Journal Article
Abbas, Z. S., Liaque Latif, M., Dovlatova, N., Fox, S. C., Heptinstall, S., Dunn, W. R., & Ralevic, V. (2018). UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascular Pharmacology, 103-105, doi:10.1016/j.vph.2017.12.063. ISSN 1537-1891

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In thi... Read More

A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery (2017)
Journal Article
Donovan, J., Wong, P., Roberts, R. E., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (2017). A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular Pharmacology, 93-95, doi:10.1016/j.vph.2017.05.004

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2S) is reported to be an oxygen sensor/transducer in the vasculatu... Read More

Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release (2017)
Journal Article
Baker, H. A., Dunn, W. R., Daly, C., & Ralevic, V. (2017). Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release. Cardiovascular Research, doi:10.1093/cvr/cvx062. ISSN 0008-6363

Aims: Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch... Read More

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed (2014)
Journal Article
Shatarat, A., Dunn, W. R., & Ralevic, V. (in press). Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed. Purinergic Signalling, 10(4), doi:10.1007/s11302-014-9426-3. ISSN 1573-9538

The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries. The a... Read More