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Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity (2022)
Journal Article
Iwabuchi, S. J., Drabek, M. M., Cottam, W. J., Tadjibaev, A., Mohammadi-Nejad, A. R., Sotiropoulos, S., …Auer, D. P. (2022). Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity. European Journal of Neuroscience, 57(2), 373-387. https://doi.org/10.1111/ejn.15880

The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to inv... Read More about Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC) (2022)
Journal Article
Tench, C., Tanasescu, R., Constantinescu, C., Auer, D., & Cottam, W. (2022). Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC). Journal of Neuroscience Methods, 372, Article 109556. https://doi.org/10.1016/j.jneumeth.2022.109556

Background: Functional MRI and voxel-based morphometry are important in neuroscience. They are technically challenging with no globally optimal analysis method, and the multiple approaches have been shown to produce different results. It is useful to... Read More about Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC).

Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial (2022)
Journal Article
Pszczolkowski, S., Cottam, W. J., Briley, P. M., Iwabuchi, S. J., Kaylor-Hughes, C., Shalabi, A., …Morriss, R. (2022). Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial. JMIR Research Protocols, 11(1), Article e31925. https://doi.org/10.2196/31925

Background: Depression is a substantial health and economic burden. In approximately one-third of patients, depression is resistant to first-line treatment; therefore, it is essential to find alternative treatments. Transcranial magnetic stimulation... Read More about Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial.

Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., Fernandes, G. S., …Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 161(6), 1255-1263. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Coordinate based meta-analysis of networks in neuroimaging studies (2019)
Journal Article
Tench, C., Tanasescu, R., Constantinescu, C., Cottam, W., & Auer, D. (2020). Coordinate based meta-analysis of networks in neuroimaging studies. NeuroImage, 205, 1-12. https://doi.org/10.1016/j.neuroimage.2019.116259

Meta-analysis of summary results from published neuroimaging studies independently testing a common hypothesis is performed using coordinate based meta-analysis (CBMA), which tests for consistent activation (in the case of functional MRI studies) of... Read More about Coordinate based meta-analysis of networks in neuroimaging studies.

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), https://doi.org/10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety (2016)
Journal Article
Cottam, W. J., Condon, L., Alshuft, H., Reckziegel, D., & Auer, D. P. (in press). Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. NeuroImage: Clinical, 12, https://doi.org/10.1016/j.nicl.2016.06.022

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arteria... Read More about Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety.

Functional reorganisation in chronic pain and neural correlates of pain sensitisation (2016)
Journal Article
Tanasescu, R., Cottam, W., Condon, L., Tench, C. R., & Auer, D. P. (2016). Functional reorganisation in chronic pain and neural correlates of pain sensitisation. Neuroscience and Biobehavioral Reviews, 68, 120-133. https://doi.org/10.1016/j.neubiorev.2016.04.001

© 2016 Published by Elsevier Ltd. Maladaptive mechanisms of pain processing in chronic pain conditions (CP) are poorly understood. We used coordinate based meta-analysis of 266 fMRI pain studies to study functional brain reorganisation in CP and expe... Read More about Functional reorganisation in chronic pain and neural correlates of pain sensitisation.