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All Outputs (10)

Metformin for endometrial hyperplasia (Review) (2017)
Journal Article
Clement, N. S., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2017). Metformin for endometrial hyperplasia (Review). Cochrane Database of Systematic Reviews, Article CD012214. https://doi.org/10.1002/14651858.CD012214.pub2

Background Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead... Read More about Metformin for endometrial hyperplasia (Review).

Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help? (2017)
Journal Article
Atiomo, W., Lakshmi Karanam, V., Sian, M., & Grainge, M. (2017). Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help?. Obstetrics & gynecology international journal, 8(1), Article 00277. https://doi.org/10.15406/ogij.2017.08.00277

Background: UK biobank was set up to investigate the respective contributions of genetic predisposition and environmental exposure to the development of disease and recruited participants between 2006 and 2010. Our aim was to investigate the feasibil... Read More about Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help?.

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome (2017)
Journal Article
Atiomo, W., Shafiee, M. N., Chapman, C., Metzler, V. M., Abouzeid, J., Latif, A., …Mongan, N. P. (2017). Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome. Clinical Endocrinology, 87(5), 557-565. https://doi.org/10.1111/cen.13436

OBJECTIVE: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). AIM: To investigate whether the endometrium of women with PCOS possess gene expression changes similar to those found in EC.... Read More about Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome.

Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer (2017)
Journal Article
Shafiee, M. N., Mongan, N. P., Seedhouse, C., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2017). Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica, 96(5), 556-562. https://doi.org/10.1111/aogs.13106

Introduction: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to inves... Read More about Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer.

Metformin for endometrial hyperplasia (protocol) (2016)
Journal Article
Clement, N., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2016). Metformin for endometrial hyperplasia (protocol). Cochrane Database of Systematic Reviews, 5, Article CD012214. https://doi.org/10.1002/14651858

To determine the efficacy and safety of metformin in treating women with endometrial hyperplasia

Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer (2016)
Journal Article
Shafiee, M. N., Seedhouse, C., Mongan, N., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2016). Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer. Molecular and Cellular Endocrinology, 424, 94-101. https://doi.org/10.1016/j.mce.2016.01.019

BACKGROUND Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (E... Read More about Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer.

The current provision of community-based teaching in UK medical schools: an online survey and systematic review (2014)
Journal Article
Lee, S. W., Clement, N., Tang, N., & Atiomo, W. (2014). The current provision of community-based teaching in UK medical schools: an online survey and systematic review. BMJ Open, 4, Article e005696. https://doi.org/10.1136/bmjopen-2014-005696

Objective: To evaluate the current provision and outcome of community-based education (CBE) in UK medical schools. Design and data sources: An online survey of UK medical school websites and course prospectuses and a systematic review of articles f... Read More about The current provision of community-based teaching in UK medical schools: an online survey and systematic review.

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration (2014)
Journal Article
Khan, G. H., Galazis, N., Docheva, N., Layfield, R., & Atiomo, W. (2014). Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Human Reproduction, 30(1), https://doi.org/10.1093/humrep/deu268

Study question: Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS). Summary answer: Five previously identified proteomic biomarkers were found to be c... Read More about Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.

Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom (2014)
Journal Article
Choo, T., Deb, S., Wilkins, J., & Atiomo, W. (2014). Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom. BMC Health Services Research, 14(428), https://doi.org/10.1186/1472-6963-14-428

Background: The project aim was to investigate the impact of reconfiguring gynaecology services on the key performance indicators of a University Hospital NHS Trust in the UK. The reconfiguration involved the centralisation of elective gynaecology... Read More about Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom.

Lipidomic analysis of plasma samples from women with polycystic ovary syndrome (2014)
Journal Article
Haoula, Z., Ravipati, S., Stekel, D. J., Ortori, C. A., Hodgman, C., Daykin, C., …Atiomo, W. (2015). Lipidomic analysis of plasma samples from women with polycystic ovary syndrome. Metabolomics, 11(3), 657-666. https://doi.org/10.1007/s11306-014-0726-y

Abstract Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagn... Read More about Lipidomic analysis of plasma samples from women with polycystic ovary syndrome.