All Outputs (34)

An in silico and in vitro assessment of the neurotoxicity of mefloquine (2024)
Journal Article
El Sharazly, B. M., Ahmed, A., Elsheikha, H. M., & Carter, W. G. (2024). An in silico and in vitro assessment of the neurotoxicity of mefloquine. Biomedicines, 12(3), Article 505. https://doi.org/10.3390/biomedicines12030505

Mefloquine (MQ) is a quinoline-based anti-malarial drug used for chemoprophylaxis or as treatment in combination with artesunate. Although MQ has clear anti-Plasmodium properties, it can induce neurotoxicity and undesired neuropsychiatric side effect... Read More about An in silico and in vitro assessment of the neurotoxicity of mefloquine.

Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells (2023)
Journal Article
Elmorsy, E., Al-Ghafari, A., Al Doghaither, H., Hashish, S., Salama, M., Mudyanselage, A. W., …Carter, W. G. (2023). Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells. Brain Sciences, 13(12), Article 1717. https://doi.org/10.3390/brainsci13121717

Paraquat (PQ), rotenone (RO), and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are neurotoxicants that can damage human health. Exposure to these neurotoxicants has been linked to neurodegeneration, particularly Parkinson’s disease. However, t... Read More about Differential Effects of Paraquat, Rotenone, and MPTP on Cellular Bioenergetics of Undifferentiated and Differentiated Human Neuroblastoma Cells.

Are Therapies That Target α-Synuclein Effective at Halting Parkinson’s Disease Progression? A Systematic Review (2023)
Journal Article
Rodger, A. T., ALNasser, M., & Carter, W. G. (2023). Are Therapies That Target α-Synuclein Effective at Halting Parkinson’s Disease Progression? A Systematic Review. International Journal of Molecular Sciences, 24(13), Article 11022. https://doi.org/10.3390/ijms241311022

There are currently no pharmacological treatments available that completely halt or reverse the progression of Parkinson’s Disease (PD). Hence, there is an unmet need for neuroprotective therapies. Lewy bodies are a neuropathological hallmark of PD a... Read More about Are Therapies That Target α-Synuclein Effective at Halting Parkinson’s Disease Progression? A Systematic Review.

Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins (2023)
Journal Article
Mudyanselage, A. W., Wijamunige, B. C., Kocon, A., & Carter, W. G. (2023). Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins. Brain Sciences, 13(5), Article 728. https://doi.org/10.3390/brainsci13050728

Organophosphate (OP) and carbamate pesticides are toxic to pests through targeted inhibition of acetylcholinesterase (AChE). However, OPs and carbamates may be harmful to non-target species including humans and could induce developmental neurotoxicit... Read More about Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins.

Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress (2023)
Journal Article
ALNasser, M. N., AlSaadi, A. M., Whitby, A., Kim, D. H., Mellor, I. R., & Carter, W. G. (2023). Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress. Life, 13(4), Article 1019. https://doi.org/10.3390/life13041019

Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a mechanism of neurodegeneration, and the release of L-Glu after stroke onset leads to a toxicity cascade that results in neuronal death. The acai berry (Euterpe... Read More about Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress.

Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis (2022)
Journal Article
El Sharazly, B. M., Aboul Asaad, I. A., Yassen, N. A., El Maghraby, G. M., Carter, W. G., Mohamed, D. A., …Ismail, H. I. (2023). Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis. Acta Tropica, 239, Article 106810. https://doi.org/10.1016/j.actatropica.2022.106810

Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with niosomes to treat acute and chronic phases of toxoplasmosis in experime... Read More about Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis.

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019 (2022)
Journal Article
Naseem, A., Rasool, F., Ahmed, A., & Carter, W. G. (2023). The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019. Current Issues in Molecular Biology, 45(1), 12-32. https://doi.org/10.3390/cimb45010002

COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19. This study aimed to explore the potential ability of natur... Read More about The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019.

A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease (2022)
Journal Article
AL Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease. Molecules, 27(15), Article 4891. https://doi.org/10.3390/molecules27154891

Alzheimer's disease (AD) is characterised by progressive neuronal atrophy and the loss of neuronal function as a consequence of multiple pathomechanisms. Current AD treatments primarily operate at a symptomatic level to treat a cholinergic deficiency... Read More about A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease.

An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions (2022)
Journal Article
Elmorsy, E., Al-Ghafari, A., Al Doghaither, H., Salama, M., & Carter, W. G. (2022). An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions. Brain Sciences, 12(8), Article 975. https://doi.org/10.3390/brainsci12080975

Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential development of neurodegenerative diseases (NDDs). This study aimed to consider the neurotoxicity of three widely utilized pesticides: malathion, chlorpyrifos... Read More about An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions.

The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study (2022)
Journal Article
Ali, U. A., Iftikhar, N., Amat-Ur-rasool, H., Ahmed, M., Hafeez, J., & Carter, W. G. (2022). The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study. Healthcare, 10(6), Article 1049. https://doi.org/10.3390/healthcare10061049

The COVID-19 pandemic has had a damaging impact on global health. Post-infection, patients may experience mental health difficulties and therefore require suitable psychological treatment and support. The objective of this study was to identify the p... Read More about The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study.

Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review (2022)
Journal Article
Al-Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. Brain Sciences, 12(5), Article 577. https://doi.org/10.3390/brainsci12050577

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration. To investig... Read More about Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review.

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease (2021)
Journal Article
Amat-Ur-rasool, H., Ahmed, M., Hasnain, S., Ahmed, A., & Carter, W. G. (2022). In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease. Current Issues in Molecular Biology, 44(1), 152-175. https://doi.org/10.3390/cimb44010012

The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is... Read More about In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease.

The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies (2021)
Journal Article
Prakash, S., & Carter, W. G. (2021). The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies. Brain Sciences, 11(12), Article 1573. https://doi.org/10.3390/BRAINSCI11121573

Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need for the provision of neuroprotective agents. Cannabis-derived phytocannabinoids (CDCs) and resveratrol (RSV) may... Read More about The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies.

Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease (2021)
Journal Article
Amat-ur-Rasool, H., Ahmed, M., Hasnain, S., & Carter, W. G. (2021). Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease. Brain Sciences, 11(2), Article 184. https://doi.org/10.3390/brainsci11020184

Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs). Herein, the potency of the ChEIs, donepezil, tacri... Read More about Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease.

Potential nutraceutical properties of leaves from several commonly cultivated plants (2020)
Journal Article
Amat-ur-Rasool, H., Symes, F., Tooth, D., Schaffert, L., Elmorsy, E., Ahmed, M., …Carter, W. G. (2020). Potential nutraceutical properties of leaves from several commonly cultivated plants. Biomolecules, 10(11), 1-22. https://doi.org/10.3390/biom10111556

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase i... Read More about Potential nutraceutical properties of leaves from several commonly cultivated plants.

Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier (2020)
Journal Article
Alelwani, W., Elmorsy, E., Kattan, S. W., Babteen, N. A., Alnajeebi, A. M., Al-Ghafari, A., & Carter, W. G. (2020). Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier. Toxicology Letters, 333, 184-191. https://doi.org/10.1016/j.toxlet.2020.08.006

Carbamazepine (CBZ) is a widely employed anti-seizure medication that crosses the blood-brain barrier (BBB) to exert its anti-convulsant action. The effects of CBZ on components of the BBB have yet to be completely delineated. Hence the current study... Read More about Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier.

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review (2020)
Journal Article
Schaffert, L., & Carter, W. G. (2020). Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review. Brain Sciences, 10(4), https://doi.org/10.3390/brainsci10040232

The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function. Dysregulated PTMs may influence the propensity for... Read More about Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review.

The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress (2019)
Journal Article
Al-Ghafari, A., Elmorsy, E., Fikry, E., Alrowaili, M., & Carter, W. G. (2019). The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress. PLoS ONE, 14(11), https://doi.org/10.1371/journal.pone.0225341

The heavy metals (HMs) lead and cadmium are persistent environmental pollutants capable of inducing ill-health in exposed individuals. One of the primary sites of accumulation and potential damage from HMs is bone, and we therefore examined the acute... Read More about The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress.

A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism (2019)
Journal Article
Jones, J., Dorling, J. L., Clayton, D. J., King, J. A., Carter, W. G., Thackray, A. E., …Stensel, D. J. (2019). A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism. American Journal of Clinical Nutrition, 110(5), 1055-1066. https://doi.org/10.1093/ajcn/nqz188

Copyright © American Society for Nutrition 2019. BACKGROUND: The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is associated with higher acyl-ghrelin (AG) concentrations, higher energy intake, and obesity, although exercise may mitiga... Read More about A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism.

An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress (2019)
Journal Article
Nwidu, L. L., Alikwe, P. C. N., Elmorsy, E., & Carter, W. G. (2019). An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress. Medicines, 6(1), Article 15. https://doi.org/10.3390/medicines6010015

Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants potentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant, anti-acetylcholinesterase (AChE), and total phenolic and fla... Read More about An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress.