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An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress (2019)
Journal Article
Nwidu, L. L., Alikwe, P. C. N., Elmorsy, E., & Carter, W. G. (2019). An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress. Medicines, 6(1), doi:10.3390/medicines6010015

Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants potentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant, anti-acetylcholinesterase (AChE), and total phenolic and fla... Read More

The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing (2018)
Journal Article
Labisso, W., Raulin, A., Nwidu, L., Kocon, A., Wayne, D., Erdozain, A., …Carter, W. (2018). The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing. Brain Sciences, 8(9), doi:10.3390/brainsci8090175

Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals w... Read More

In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria (2018)
Journal Article
Nwidu, L. L., Elmorsy, E., Aprioku, J., Siminialayi, I., & Carter, W. (2018). In vitro anti-cholinesterase and antioxidant activity of extracts of Moringa oleifera plants from Rivers State, Niger Delta, Nigeria. Medicines, 5(3), doi:10.3390/medicines5030071. ISSN 2305-6320

This study evaluated Moringa oleifera extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of Moringa oleifera were evaluated for inhibition of acetylcholin... Read More

Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Almutairi, F. M., Aggour, A. M., & Carter, W. (2017). Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations. Toxicology in Vitro, 44, doi:10.1016/j.tiv.2017.07.011. ISSN 0887-2333

Antidepressants are commonly employed for the treatment of major depressive disorders and other psychiatric conditions. We investigated the relatively acute cytotoxic effects of three commonly prescribed antidepressants: fluoxetine, sertraline, and c... Read More

Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea (2017)
Journal Article
Nwidu, L. L., Elmorsy, E., Thornton, J., Wijamunige, B., Wijesekara, A., Tarbox, R., …Carter, W. (2017). Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea. Pharmaceutical Biology, 55(1), doi:10.1080/13880209.2017.1339283. ISSN 1388-0209

Context: There is an unmet need to discover new treatments for Alzheimer’s disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae)... Read More

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury (2016)
Journal Article
pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22(27), doi:10.3748/wjg.v22.i27.6192. ISSN 1007-9327

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cel... Read More

Alcohol-related brain damage in humans (2014)
Journal Article
Quintas, L. E. M., Erdozain, A. M., Morentin, B., Bedford, L., King, E., Tooth, D., …Carter, W. G. (2014). Alcohol-related brain damage in humans. PLoS ONE, 9(4), doi:10.1371/journal.pone.0093586. ISSN 1932-6203

Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann’s area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining a... Read More

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article
Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. (2013). Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms. PLoS ONE, 8(4), doi:10.1371/journal.pone.0061442. ISSN 1932-6203

Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides (2008)
Journal Article
Tarhoni, M. H., Lister, T., Ray, D. E., & Carter, W. G. (2008). Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers, 13(4), doi:10.1080/13547500801973563. ISSN 1354-750X

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. Rat or human plasma... Read More