Research Repository

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Comparison of different human tissue processing methods for maximization of bacterial recovery (2018)
Journal Article
Askar, M., Ashraf, W., Scammell, B., & Bayston, R. (2019). Comparison of different human tissue processing methods for maximization of bacterial recovery. European Journal of Clinical Microbiology and Infectious Diseases, 38(1), 149-155. doi:10.1007/s10096-018-3406-4

Tissues are valuable microbiological samples that have proved superiority over swabs. Culture of tissue samples is used in the diagnosis of a variety of infections. However, as well as factors such as the site of obtaining the sample, the number of s... Read More

Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis? (2015)
Journal Article
Bayston, R., Ashraf, W., & Ortori, C. (2015). Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?. Journal of Neurosurgery, 124(2), doi:10.3171/2014.12.JNS141900. ISSN 0022-3085

OBJECT Recently concern has arisen over the effect of released antimicrobial agents from antibiotic-impregnated external ventricular drainage (EVD) catheters on the reliability of CSF culture for diagnosis of ventriculitis. The authors designed a... Read More

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model (2014)
Journal Article
McLaren, J. S., White, L., Cox, H., Ashraf, W., Rahman, C., Blunn, G., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model. eCells and Materials Journal, 27, doi:10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More

Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro (2012)
Journal Article
Bayston, R., Ullas, G., & Ashraf, W. (2012). Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro. Antimicrobial Agents and Chemotherapy, 56(6), doi:10.1128/AAC.06326-11. ISSN 0066-4804

Cerebrospinal fluid (CSF) shunts used to treat hydrocephalus have an overall infection rate of about 10% of operations. The commonest causative bacteria are Staphylococcus epidermidis, followed by Staphylococcus aureus and enterococci. Major difficul... Read More