Research Repository

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Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes (2017)
Journal Article
Duncan, G., Firth, K. S., George, V., Hoang, M. D., Stainforth, A., Smith, G., & Denning, C. (2017). Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes. Stem Cells and Development, 26(23), doi:10.1089/scd.2017.0172. ISSN 1547-3287

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart. This is especially so for long QT syndrome (LQTS), which is caused by perturbation of ion... Read More

Contemporary review of risk-stratified management in acute uncomplicated and complicated diverticulitis (2016)
Journal Article
Boermeester, M. A., Humes, D., Velmahos, G. C., & Søreide, K. (in press). Contemporary review of risk-stratified management in acute uncomplicated and complicated diverticulitis. World Journal of Surgery, 40(10), doi:10.1007/s00268-016-3560-8. ISSN 0364-2313

BACKGROUND: Acute colonic diverticulitis is a common clinical condition. Severity of the disease is based on clinical, laboratory, and radiological investigations and dictates the need for medical or surgical intervention. Recent clinical trials have... Read More

Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation (2015)
Journal Article
Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., …Alexander, M. R. (2015). Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27(27), doi:10.1002/adma.201501351. ISSN 0935-9648

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to... Read More

Current status of drug screening and disease modelling in human pluripotent stem cells (2013)
Journal Article
Rajamohan, D., Matsa, E., Kalra, S., Crutchley, J., Patel, A., George, V., & Denning, C. (2013). Current status of drug screening and disease modelling in human pluripotent stem cells. BioEssays, 35(3), doi:10.1002/bies.201200053. ISSN 0265-9247

The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overc... Read More