Research Repository

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Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system (2016)
Journal Article
Abdullah, Z., & Bayraktutan, U. (2016). Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system. BBA - Biochimica et Biophysica Acta, 1862(7), doi:10.1016/j.bbadis.2016.03.014. ISSN 0006-3002

Ischaemic stroke, accompanied by neuroinflammation, impairs blood-brain barrier integrity through a complex mechanism involving both protein kinase C (PKC) and urokinase. Using an in vitro model of human blood-brain barrier (BBB) composed of brain mi... Read More

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage (2015)
Journal Article
Abdullah, Z., Rakkar, K., Bath, P. M., & Bayraktutan, U. (2015). Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage. Molecular and Cellular Neuroscience, 69, doi:10.1016/j.mcn.2015.11.003. ISSN 1044-7431

Cerebral ischaemia, associated with neuroinflammation and oxidative stress, is known to perturb blood–brain barrier (BBB) integrity and promote brain oedema formation. Using an in vitro model of human BBB composed of brain microvascular endothelial c... Read More

Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis (2015)
Journal Article
Rakkar, K., & Bayraktutan, U. (2016). Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis. BBA - Molecular Basis of Disease, 1862(1), doi:10.1016/j.bbadis.2015.10.016. ISSN 0925-4439

An increase in intracellular calcium represents one of the early events during an ischaemic stroke. It triggers many downstream processes which promote the formation of brain oedema, the leading cause of death after an ischaemic stroke. As impairment... Read More

NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time (2014)
Journal Article
Abdullah, Z., & Bayraktutan, U. (2014). NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time. Molecular and Cellular Neuroscience, 61, doi:10.1016/j.mcn.2014.06.002. ISSN 1044-7431

The pro-inflammatory cytokine TNF-α severely perturbs the integrity of the blood–brain barrier (BBB). This study explored the specific roles of NADPH oxidase and associated downstream effectors by using human brain microvascular endothelial cells (HB... Read More

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability (2009)
Journal Article
hyperpermeability. Diabetes, Obesity and Metabolism, 11(5), doi:10.1111/j.1463-1326.2008.00987.x. ISSN 1462-8902

Aims: Hyperglycaemia (HG), in stroke patients, is associated with worse neurological outcome by compromising endothelial cell function and the blood–brain barrier (BBB) integrity. We have studied the contribution of HG-mediated generation of oxidati... Read More

Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity (2006)
Journal Article
Mahadevan, V., Campbell, M., McKeown, P., & Bayraktutan, U. (2006). Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular Research, 72, ISSN 0008-6363

Objective- This study investigated whether differences exist in atherogen-induced migratory behaviors and basal antioxidant enzyme capacity of vascular smooth muscle cells (VSMC) from human coronary (CA) and internal mammary (IMA) arteries. Methods-... Read More

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth (2004)
Journal Article
Bayraktutan, U. (2004). Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Journal of Molecular and Cellular Cardiology, 36, ISSN 0022-2828

Reactive oxygen species (ROS) including nitric oxide (NO) and superoxide anion (O2-) are associated with cell migration, proliferation and many growth-related diseases. The objective of this study was to determine whether there was a reciprocal relat... Read More

High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells (2004)
Journal Article
Bayraktutan, U., Weidig, P., McMaster, D., & Ulker, S. (2004). High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells

Objective: Excess levels of free radicals such as nitric oxide (NO) and superoxide anion (O2-)are associated with the pathogenesis of endothelial cell dysfunction in diabetes mellitus. This study was designed to investigate the underlying causes of o... Read More