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Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability (2009)
Journal Article
Allen, C., & Bayraktutan, U. (2009). Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability. Diabetes, Obesity and Metabolism, 11(5), https://doi.org/10.1111/j.1463-1326.2008.00987.x

Aims: Hyperglycaemia (HG), in stroke patients, is associated with worse neurological outcome by compromising endothelial cell function and the blood–brain barrier (BBB) integrity. We have studied the contribution of HG-mediated generation of oxidati... Read More about Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability.

Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity (2006)
Journal Article
Mahadevan, V., Campbell, M., McKeown, P., & Bayraktutan, U. (2006). Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular Research, 72,

Objective- This study investigated whether differences exist in atherogen-induced migratory behaviors and basal antioxidant enzyme capacity of vascular smooth muscle cells (VSMC) from human coronary (CA) and internal mammary (IMA) arteries. Methods-... Read More about Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity.

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth (2004)
Journal Article
Bayraktutan, U. (2004). Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Journal of Molecular and Cellular Cardiology, 36,

Reactive oxygen species (ROS) including nitric oxide (NO) and superoxide anion (O2-) are associated with cell migration, proliferation and many growth-related diseases. The objective of this study was to determine whether there was a reciprocal relat... Read More about Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth.

High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells (2004)
Journal Article
Bayraktutan, U., Weidig, P., McMaster, D., & Ulker, S. (2004). High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells

Objective: Excess levels of free radicals such as nitric oxide (NO) and superoxide anion (O2-)are associated with the pathogenesis of endothelial cell dysfunction in diabetes mellitus. This study was designed to investigate the underlying causes of o... Read More about High glucose mediates prooxidant and antioxidant enzyme activities in coronary endothelial cells.

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells (2000)
Journal Article
Bayraktutan, U., Blayney, L., & Shah, A. (2000). Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells

The production of reactive oxygen species (ROS) within endothelial cells may have several effects, including alterations in the activity of paracrine factors, gene expression, apoptosis, and cellular injury. Recent studies indicate that a phagocyte... Read More about Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells.