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Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development (2017)
Journal Article
Ghosh, T. K., Aparicio-Sánchez, J. J., Buxton, S., Ketley, A., Mohamed, T., Rutland, C. S., …Brook, J. D. (2018). Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. Journal of Molecular and Cellular Cardiology, 114, doi:10.1016/j.yjmcc.2017.11.013. ISSN 0022-2828

TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper - limb. Several studies have provided significant insight int... Read More