Research Repository

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Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology (2018)
Journal Article
Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L., Bath, P. M., …Work, L. M. (2018). Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), doi:10.1042/CS20171620. ISSN 0143-5221

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical resea... Read More

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models (2017)
Journal Article
Koch, S., Mueller, S., Foddis, M., Bienert, T., von Elverfeldt, D., Knab, F., …Boehm-Sturm, P. (in press). Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. Journal of Cerebral Blood Flow and Metabolism, doi:10.1177/0271678X17726635. ISSN 0271-678X

Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the... Read More

The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) (2017)
Journal Article
Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V., Deuchar, G. A., Farr, T. D., …Macrae, I. M. (in press). The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of Cerebral Blood Flow and Metabolism, doi:10.1177/0271678X17709185. ISSN 0271-678X

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and ani... Read More

Infections up to 76 days after stroke increase disability and death (2017)
Journal Article
Learoyd, A., Woodhouse, L. J., Shaw, L., Sprigg, N., Bereczki, D., Berge, E., …Trueman, R. C. (in press). Infections up to 76 days after stroke increase disability and death. Translational Stroke Research, doi:10.1007/s12975-017-0553-3. ISSN 1868-4483

Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke... Read More

Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke (2017)
Journal Article
Ahmed, J., Dwyer, D. E., Farr, T. D., Harrison, D. J., Dunnett, S. B., & Trueman, R. C. (in press). Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow and Metabolism, 37(3), doi:10.1177/0271678X16684141. ISSN 0271-678X

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimoto... Read More

Recent progress in translational research on neurovascular and neurodegenerative disorders (2017)
Journal Article
Demuth, H., Dijkhuizen, R. M., Farr, T. D., Gelderblom, M., Horsburgh, K., Iadecola, C., …Boltze, J. (2017). Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35(1), doi:10.3233/RNN-160690. ISSN 0922-6028

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundament... Read More

Interaction of ARC and Daxx: a novel endogenous target to preserve motor function and cell loss after focal brain ischemia in mice (2016)
Journal Article
ischemia in mice. Journal of Neuroscience, 36(31), doi:10.1523/JNEUROSCI.4428-15.2016. ISSN 1529-2401

The aim of this study was to explore the signaling and neuroprotective effect of transactivator of transcription (TAT) protein transduction of the apoptosis repressor with CARD (ARC) in in vitro and in vivo models of cerebral ischemia in mice. In mic... Read More

Labeling of mesenchymal stem cells for MRI with single-cell sensitivity (2016)
Journal Article
Ariza de Schellenberger, A., Kratz, H., Farr, T. D., Löewa, N., Hauptmann, R., Wagner, S., …Schellenberger, E. A. (2016). Labeling of mesenchymal stem cells for MRI with single-cell sensitivity. International Journal of Nanomedicine, 11, doi:10.2147/IJN.S101141. ISSN 1176-9114

Sensitive cell detection by magnetic resonance imaging (MRI) is an important tool for the development of cell therapies. However, clinically approved contrast agents that allow single-cell detection are currently not available. Therefore, we compared... Read More

Bioluminescence imaging of stroke-induced endogenous neural stem cell response (2014)
Journal Article
Vandeputte, C., Reumers, V., Aelvoet, S., Thiry, I., De Swaef, S., Van den Haute, C., …Baekelandt, V. (2014). Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of Disease, 69, doi:10.1016/j.nbd.2014.05.014. ISSN 0969-9961

Brain injury following stroke affects neurogenesis in the adult mammalian brain. However, a complete under¬standing of the origin and fate of the endogenous neural stem cells (eNSCs) in vivo is missing. Tools and technol¬ogy that allow non-invasive i... Read More