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Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission (2018)
Journal Article
Dobson, K. L., Smith, Z. H., & Bellamy, T. C. (2018). Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission. PLoS ONE, 13(7), 1-15. doi:10.1371/journal.pone.0200937

At parallel fibre terminals in the cerebellar cortex, glutamate released outside of the active zone can activate AMPA receptors on juxtaposed Bergmann glial cell processes. This process is termed “ectopic” release, and allows for directed transmissio... Read More

A Bayesian approach to modelling heterogeneous calcium responses in cell populations (2017)
Journal Article
Tilunaite, A., Croft, W., Russell, N. A., Bellamy, T. C., & Thul, R. (2017). A Bayesian approach to modelling heterogeneous calcium responses in cell populations. PLoS Computational Biology, 13(10), doi:10.1371/journal.pcbi.1005794. ISSN 1553-734X

Calcium responses have been observed as spikes of the whole-cell calcium concentration in numerous cell types and are essential for translating extracellular stimuli into cellular responses. While there are several suggestions for how this encoding i... Read More

Probabilistic encoding of stimulus strength in astrocyte global calcium signals (2015)
Journal Article
Croft, W., Reusch, K., Tilunaite, A., Russell, N. A., Thul, R., & Bellamy, T. C. (2016). Probabilistic encoding of stimulus strength in astrocyte global calcium signals. Glia, 64(4), doi:10.1002/glia.22947. ISSN 0894-1491

Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The differential roles of such local or global calcium signaling are under intense investigation, but th... Read More

Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. (2015)
Journal Article
Dobson, K. L., & Bellamy, T. (2015). Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. Neural Plasticity, 2015, doi:10.1155/2015/602356

In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2+-perm... Read More

Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling (2015)
Journal Article
Dobson, K., Jackson, C., Balakrishna, S., & Bellamy, T. C. (2015). Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PLoS ONE, 10(5), 1-23. doi:10.1371/journal.pone.0125974

Background Cerebellar parallel fibres release glutamate at both the synaptic active zone and at extrasynaptic sites—a process known as ectopic release. These sites exhibit different short-term and long-term plasticity, the basis of which is incomple... Read More