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All Outputs (8)

Characterization of neuronal viability and network activity under microfluidic flow (2021)
Journal Article
Herzog, N., Johnstone, A., Bellamy, T., & Russell, N. (2021). Characterization of neuronal viability and network activity under microfluidic flow. Journal of Neuroscience Methods, 358, Article 109200. https://doi.org/10.1016/j.jneumeth.2021.109200

Background: Microfluidics technology has the potential to allow precise control of the temporal and spatial aspects of solute concentration, making it highly relevant for the study of volume transmission mechanisms in neural tissue. However, full uti... Read More about Characterization of neuronal viability and network activity under microfluidic flow.

Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission (2018)
Journal Article
Dobson, K. L., Smith, Z. H., & Bellamy, T. C. (2018). Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission. PLoS ONE, 13(7), 1-15. https://doi.org/10.1371/journal.pone.0200937

At parallel fibre terminals in the cerebellar cortex, glutamate released outside of the active zone can activate AMPA receptors on juxtaposed Bergmann glial cell processes. This process is termed “ectopic” release, and allows for directed transmissio... Read More about Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission.

Probabilistic encoding of stimulus strength in astrocyte global calcium signals (2015)
Journal Article
Croft, W., Reusch, K., Tilunaite, A., Russell, N. A., Thul, R., & Bellamy, T. C. (2016). Probabilistic encoding of stimulus strength in astrocyte global calcium signals. Glia, 64(4), 537-552. https://doi.org/10.1002/glia.22947

© 2016 Wiley Periodicals, Inc. Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The differential roles of such local or global calcium signaling are unde... Read More about Probabilistic encoding of stimulus strength in astrocyte global calcium signals.

Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. (2015)
Journal Article
Dobson, K. L., & Bellamy, T. (2015). Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. Neural Plasticity, 2015, https://doi.org/10.1155/2015/602356

In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2+-perm... Read More about Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum..

Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling (2015)
Journal Article
Dobson, K., Jackson, C., Balakrishna, S., & Bellamy, T. C. (2015). Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PLoS ONE, 10(5), 1-23. https://doi.org/10.1371/journal.pone.0125974

Background Cerebellar parallel fibres release glutamate at both the synaptic active zone and at extrasynaptic sites—a process known as ectopic release. These sites exhibit different short-term and long-term plasticity, the basis of which is incomple... Read More about Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling.

Stimulus Discrimination in Cerebellar Purkinje Neurons (2014)
Journal Article
Reusch, K., Russell, N. A., & Bellamy, T. C. (2014). Stimulus Discrimination in Cerebellar Purkinje Neurons. PLoS ONE, 9(2), https://doi.org/10.1371/journal.pone.0087828

Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic input. Overlaid on this intrinsic activity, excitatory input from parallel fibres can add simple spikes to the output train, whereas inhibitory input from interneurons can intr... Read More about Stimulus Discrimination in Cerebellar Purkinje Neurons.