Research Repository

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Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, doi:10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More

Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition (2017)
Journal Article
Bast, T., Pezze, M., & McGarrity, S. (2017). Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition. British Journal of Pharmacology, 174(19), doi:10.1111/bph.13850. ISSN 0007-1188

We review recent evidence concerning the significance of inhibitory GABA transmission and of neural disinhibition, i.e. deficient GABA transmission, within prefrontal cortex and hippocampus for clinically relevant cognitive functions. Both regions su... Read More

Hippocampal neural disinhibition causes attentional and memory deficits (2016)
Journal Article
McGarrity, S., Mason, R., Fone, K. C., Pezze, M. A., & Bast, T. (2017). Hippocampal neural disinhibition causes attentional and memory deficits. Cerebral Cortex, 27(9), doi:10.1093/cercor/bhw247. ISSN 1047-3211

Subconvulsive hippocampal neural disinhibition, that is reduced GABAergic inhibition, has been implicated in neuropsychiatric disorders characterized by attentional and memory deficits, including schizophrenia and age-related cognitive decline. Consi... Read More

Spatial memory: behavioural determinants of persistence in the watermaze delayed matching-to-place task (2014)
Journal Article
da Silva, B. M., Bast, T., & Morris, R. G. (2014). Spatial memory: behavioural determinants of persistence in the watermaze delayed matching-to-place task. Learning and Memory, 21, doi:10.1101/lm.032169.113. ISSN 1072-0502

The watermaze delayed matching-to-place (DMP) task was modified to include probe trials, to quantify search preference for the correct place. Using a zone-analysis of search-preference, a gradual decay of one-trial memory in rats was observed over 24... Read More

Hippocampus and two way active avoidance conditioning: contrasting effects of cytotoxic lesion and temporary inactivation
Journal Article
Wang, J., Bast, T., Wang, Y., & Zhang, W. Hippocampus and two way active avoidance conditioning: contrasting effects of cytotoxic lesion and temporary inactivation. Hippocampus, doi:10.1002/hipo.22471. ISSN 1050-9631

Hippocampal lesions tend to facilitate two way active avoidance (2WAA) conditioning, where rats learn to cross to the opposite side of a conditioning chamber to avoid a tone-signaled footshock. This classical finding has been suggested to reflect tha... Read More