Research Repository

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Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations (2018)
Journal Article
McKeever, T., Mortimer, K., Wilson, A., Walker, S., Brightling, C., Skeggs, A., …Harrison, T. (2018). Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. New England Journal of Medicine, 378(10), doi:10.1056/NEJMoa1714257. ISSN 0028-4793

BACKGROUND Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a temporary quadrupling of the dose of inhaled gluc... Read More

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., …Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), doi:10.1164/rccm.201604-0822OC. ISSN 1073-449X

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction (2016)
Journal Article
Tubby, C., Negm, O. H., Harrison, T. W., Tighe, P. J., Todd, I., & Fairclough, L. C. (in press). Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma, doi:10.1080/02770903.2016.1236941. ISSN 0277-0903

Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obs... Read More

The differential effects of azithromycin on the airway epithelium in vitro and in vivo (2016)
Journal Article
Slater, M., Torr, E., Harrison, T. W., Forrester, D. L., Knox, A., Shaw, D. E., & Sayers, I. (2016). The differential effects of azithromycin on the airway epithelium in vitro and in vivo. Physiological Reports, 4(18), doi:10.14814/phy2.12960

Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these benefi- cial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on... Read More

Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial (2016)
Journal Article
Johnson, S. L., Szigeti, M., Cross, M., Brightling, C., Chaudhuri, R., Harrison, T. W., …Chauhan, A. (2016). Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), doi:10.1001/jamainternmed.2016.5664. ISSN 2168-6106

IMPORTANCE Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use. OBJECTIVE To determine whether azithromycin added to standard care for asthma attacks i... Read More

Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial (2016)
Journal Article
Anderson, J., Mortimer, K., Pang, L., Smith, K., Bailey, H., Hodgson, D., …Harrison, T. W. (2016). Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial. PLoS ONE, 11(8), doi:10.1371/journal.pone.0160257. ISSN 1932-6203

Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed... Read More

Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial (2016)
Journal Article
Leroyer, C., Anderson, J., Mortimer, K., Pang, L., Smith, K., Bailey, H., …Harrison, T. W. (2016). Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial. PLoS ONE, 11(8), doi:10.1371/journal.pone.0160257. ISSN 1932-6203

Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed... Read More

Assessment of a rapid liquid-based cytology method for measuring sputum cell counts (2016)
Journal Article
Martin, M., Lee, H., Meakin, G., Green, A., Simms, R., Reynolds, C., …Harrison, T. W. (in press). Assessment of a rapid liquid-based cytology method for measuring sputum cell counts. Thorax, doi:10.1136/thoraxjnl-2016-208817

Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the cu... Read More

Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016, doi:10.1155/2016/3604842. ISSN 0962-9351

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More

The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial (2016)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Oborne, J., Meakin, G., Bailey, H., …Harrison, T. (2016). The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial. Chest, 149(4), 1052-1060. doi:10.1016/j.chest.2015.12.036

Background Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New a... Read More

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., …Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. doi:10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA) (2015)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Meakin, G., Bailey, H., Pavord, I., …Harrison, T. W. (2015). A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70(6), 559-565. doi:10.1136/thoraxjnl-2014-206481

Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an e... Read More

The impact of azithromycin therapy on the airway microbiota in asthma (2014)
Journal Article
Slater, M., Rivett, D. W., Williams, L., Martin, M., Harrison, T. W., Sayers, I., …Shaw, D. E. (2014). The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69(7), doi:10.1136/thoraxjnl-2013-204517. ISSN 0040-6376

There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a... Read More