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Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination (2022)
Journal Article
Adeboyejo, K., King, B., Tsoleridis, T., Tarr, A. W., McLauchlan, J., Irving, W. L., …McClure, C. P. (2023). Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination. Journal of Medical Virology, 95(1), Article e28178. https://doi.org/10.1002/jmv.28178

Background andAims: The newly developed direct-acting antivirals have revolutionized the treatment of chronic hepatitis C virus (HCV), with cure rates as high as 98% in some cohorts. Although genome sequencing has demonstrated that some subtypes of H... Read More about Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination.

Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity (2022)
Journal Article
Howson-Wells, H. C., Tsoleridis, T., Zainuddin, I., Tarr, A. W., Irving, W. L., Ball, J. K., …McClure, C. P. (2022). Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity. Microbial Genomics, 8(5), https://doi.org/10.1099/mgen.0.000825

Enterovirus D68 (EV-D68) has recently been identified in biennial epidemics coinciding with diagnoses of non-polio acute flaccid paralysis/myelitis (AFP/AFM). We investigated the prevalence, genetic relatedness and associated clinical features of EV-... Read More about Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity.

The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 Outbreaks (2021)
Journal Article
Francis, R. V., Billam, H., Clarke, M., Yates, C., Tsoleridis, T., Berry, L., …McClure, C. P. (2022). The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 Outbreaks. Journal of Infectious Diseases, 225(1), 10-18. https://doi.org/10.1093/infdis/jiab483

Nosocomial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have severely affected bed capacity and patient flow. We utilized whole-genome sequencing (WGS) to identify outbreaks and focus infection control resources and interve... Read More about The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 Outbreaks.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., …Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs). Biointerphases, 15, Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed mechan... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs).

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles. Biointerphases, 15(6), Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable the rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed me... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles.

Discovery of novel alphacoronaviruses in European rodents and shrews (2016)
Journal Article
Tsoleridis, T., Onianwa, O., Horncastle, E., Dayman, E., Zhu, M., Danjittrong, T., …McClure, P. (2016). Discovery of novel alphacoronaviruses in European rodents and shrews. Viruses, 8(3), Article 84. https://doi.org/10.3390/v8030084

Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex ar... Read More about Discovery of novel alphacoronaviruses in European rodents and shrews.

A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance (2015)
Journal Article
Urbanowicz, R. A., McClure, P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., …Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of Virology, 90(7), 3288-3301. https://doi.org/10.1128/JVI.02700-15

Despite significant advances in the treatment of hepatitis C virus (HCV) infection, the need to develop preventative vaccines remains. Identification of the best vaccine candidates and evaluation of their performance in preclinical and clinical devel... Read More about A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance.