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Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., …Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. doi:10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More

Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis (2018)
Journal Article
Drury, R. J., Falah, Y., Gowland, P. A., Evangelou, N., Bright, M. G., & Francis, S. T. (2018). Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis. European Radiology, ISSN 0938-7994

Objectives Assess the feasibility of using an optimised ultra-high-field high-spatial-resolution low-distortion ASL MRI acquisition to measure focal haemodynamic pathology in cortical lesions (CLs) in Multiple Sclerosis (MS). Methods Twelve... Read More

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, doi:10.1186/s41747-018-0056-3. ISSN 2509-9280

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More

Mapping the topological organisation of beta oscillations in motor cortex using MEG (2018)
Journal Article
Barratt, E., Francis, S. T., Morris, P. G., & Brookes, M. J. (2018). Mapping the topological organisation of beta oscillations in motor cortex using MEG. NeuroImage, doi:10.1016/j.neuroimage.2018.06.041. ISSN 1053-8119

The spatial topology of the human motor cortex has been well studied, particularly using functional Magnetic Resonance Imaging (fMRI) which allows spatial separation of haemodynamic responses arising from stimulation of different body parts, individu... Read More

Somatotopy in the human somatosensory system (2018)
Journal Article
Sanchez Panchuelo, R., Besle, J., Schluppeck, D., Humberstone, M., & Francis, S. (2018). Somatotopy in the human somatosensory system. Frontiers in Human Neuroscience, 12, doi:10.3389/fnhum.2018.00235. ISSN 1662-5161

Previous functional magnetic resonance imaging (fMRI) studies have demonstrated digit somatotopy in primary somatosensory cortex (SI), and even shown that at high spatial resolution it is possible to resolve within-digit somatotopy. However, fMRI stu... Read More

Multi organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging (2018)
Journal Article
Bradley, C. R., Cox, E. F., Scott, R. A., James, M. W., Kaye, P., Aithal, G. P., …Guha, I. N. (in press). Multi organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. Journal of Hepatology, doi:10.1016/j.jhep.2018.05.037. ISSN 0168-8278

Background and Aims: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the... Read More

The physiological bases of hidden noise-induced hearing loss: protocol for a functional neuroimaging study (2018)
Journal Article
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The physiological bases of hidden noise-induced hearing loss: protocol for a functional neuroimaging study. JMIR, 7(3), doi:10.2196/resprot.9095. ISSN 1438-8871

Background: Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is comm... Read More

Variation in thermally induced taste response across thermal tasters (2018)
Journal Article
Skinner, M., Eldeghaidy, S., Ford, R., Giesbrecht, T., Thomas, A., Francis, S., & Hort, J. (2018). Variation in thermally induced taste response across thermal tasters. Physiology and Behavior, 188, (67-78). doi:10.1016/j.physbeh.2018.01.017. ISSN 1873-507X

Thermal tasters (TTs) perceive thermally induced taste (thermal taste) sensations when the tongue is stimulated with temperature in the absence of gustatory stimuli, while thermal non tasters (TnTs) only perceive temperature. This is the first study... Read More

Cortical differences in diverticular disease and correlation with symptom reports (2018)
Journal Article
Pitiot, A., Smith, J. K., Garratt, J., Francis, S. T., Gowland, P. A., Spiller, R. C., & Marciani, L. (2018). Cortical differences in diverticular disease and correlation with symptom reports. Neurogastroenterology and Motility, 30(7), doi:10.1111/nmo.13303. ISSN 1350-1925

Background Recent studies have shown that the brain of patients with gastrointestinal disease differ both structurally and functionally from that of controls. Highly somatizing diverticular disease (HSDD) patients were also shown to differ from... Read More

Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans (2018)
Journal Article
Stephens, F. B., & Tsintzas, K. (2018). Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans. Biochemical Society Transactions, 46(1), doi:10.1042/BST20170198. ISSN 0300-5127

The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exer... Read More

Sodium MRI: a new frontier in imaging in nephrology (2017)
Journal Article
Francis, S. T., Buchanan, C., Prestwich, B., & Taal, M. W. (2017). Sodium MRI: a new frontier in imaging in nephrology. Current Opinion in Nephrology and Hypertension, 26(6), doi:10.1097/MNH.0000000000000370

Purpose of review This review focuses on the recent technological advances in quantitative sodium (23Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. 23Na MRI is the only non... Read More