All Outputs (9)

Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men (2015)
Journal Article
Shannon, C. E., Nixon, A. V., Greenhaff, P. L., & Stephens, F. B. (2016). Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. American Journal of Clinical Nutrition, 103(1), https://doi.org/10.3945/ajcn.115.119826

BACKGROUND: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-carnitine feeding on a daily basis in a high-carbohy... Read More about Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men.

Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry (2015)
Journal Article
Cheng, W., Palaniyappan, L., Li, M., Kendrick, K. M., Zhang, J., Luo, Q., …Feng, J. (2015). Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry. npj Schizophrenia, 1, Article 15016. https://doi.org/10.1038/npjschz.2015.16

BACKGROUND: Wernicke’s concept of ‘sejunction’ or aberrant associations among specialized brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms in psychotic disorders. Unbiased data mining of all possible brain-... Read More about Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry.

Functional connectivity in MRI is driven by spontaneous BOLD events (2015)
Journal Article
Allan, T. W., Francis, S. T., Caballero-Gaudes, C., Morris, P. G., Liddle, E., Liddle, P. F., …Gowland, P. A. (2015). Functional connectivity in MRI is driven by spontaneous BOLD events. PLoS ONE, 10(4), Article e0124577. https://doi.org/10.1371/journal.pone.0124577

A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors (2015)
Journal Article
Hoad, C. L., Palaniyappan, N., Kaye, P., Chernova, Y., James, M. W., Costigan, C., …Aithal, G. P. (2015). A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors. NMR in Biomedicine, 28(6), 706-714. https://doi.org/10.1002/nbm.3299

Liver biopsy is the standard test for the assessment of fibrosis in liver tissue of patients with chronic liver disease. Recent studies have used a non‐invasive measure of T1 relaxation time to estimate the degree of fibrosis in a single slice of the... Read More about A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors.

Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men (2015)
Journal Article
Stephens, F. B., Chee, C., Wall, B. T., Murton, A. J., Shannon, C. E., van Loon, L. J., & Tsintzas, K. (2015). Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes, 64(5), https://doi.org/10.2337/db14-0961

The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The current study investigated the effect of acutely increasing lipid a... Read More about Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men.

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD (2015)
Journal Article
Drouin-Ouellet, J., Sawiak, S. J., Cisbani, G., Lagacé, M., Kuan, W., Saint-Pierre, M., …Cicchetti, F. (2015). Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD. Annals of Neurology, 78(2), 160-177. https://doi.org/10.1002/ana.24406

Objective Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there... Read More about Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD.

Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T (2015)
Journal Article
Driver, I. D., Andoh, J., Blockley, N. P., Francis, S. T., Gowland, P. A., & Paus, T. (2015). Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T. NMR in Biomedicine, 28(5), 538-545. doi:10.1002/nbm.3282

Current functional MRI (fMRI) approaches assess underlying neuronal activity through monitoring the related local variations in cerebral blood oxygenation, blood volume and blood flow. This vascular response is likely to vary across brain regions and... Read More about Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T.

7 Tesla fMRI reveals systematic functional organization for binocular disparity in dorsal visual cortex (2015)
Journal Article
Sánchez-Panchuelo, R. M., Goncalves, N. R., Schluppeck, D., Ban, H., Sanchez-Panchuelo, R., Welchman, A. E., & Francis, S. T. (2015). 7 Tesla fMRI reveals systematic functional organization for binocular disparity in dorsal visual cortex. Journal of Neuroscience, 35(7), 3056-3072. https://doi.org/10.1523/JNEUROSCI.3047-14.2015

© 2015 the authors. The binocular disparity between the views of the world registered by the left and right eyes provides a powerful signal about the depth structure of the environment. Despite increasing knowledge of the cortical areas that process... Read More about 7 Tesla fMRI reveals systematic functional organization for binocular disparity in dorsal visual cortex.

The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG (2015)
Journal Article
Croal, P. L., Hall, E. L., Driver, I. D., Brookes, M. J., Gowland, P. A., & Francis, S. T. (2015). The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG. NeuroImage, 105, https://doi.org/10.1016/j.neuroimage.2014.10.036

The physiological effect of hyperoxia has been poorly characterised, with studies reporting conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether hyperoxia is the primary contributor to vasoconstriction or whether... Read More about The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG.