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Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers (2017)
Journal Article
Rakha, E. A., Green, A. R., Aleskandarany, M. A., Ali, R., Hodgson, E. G., Atabani, S., …Madhusudan, S. (2017). Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers. Cancer Immunology Research, 5(4), 292-299. https://doi.org/10.1158/2326-6066.CIR-16-0195

Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO... Read More about Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers.