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Identifying familial hypercholesterolaemia in primary care: Validation and optimisation of a clinical tool (FAMCAT) (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., de Lusignan, S., Sherlock, J., McGee, C., & Weng, S. (in press). Identifying familial hypercholesterolaemia in primary care: Validation and optimisation of a clinical tool (FAMCAT). BJGP Open,

Background: Familial Hypercholesterolaemia (FH), an inherited lipid disorder causing premature heart disease, is severely underdiagnosed. Aim: To evaluated the accuracy of a clinical tool (FAMCAT) for identifying FH in primary care. Design an... Read More about Identifying familial hypercholesterolaemia in primary care: Validation and optimisation of a clinical tool (FAMCAT).

Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care (2020)
Journal Article
Lee, S. I., Kai, J., Qureshi, N., Dutton, B., & Weng, S. (2020). Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care. Journal of Community Genetics, https://doi.org/10.1007/s12687-020-00452-w

© 2020, The Author(s). Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characte... Read More about Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.

Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials (2019)
Journal Article
Maula, A., Kai, J., Woolley, A. K., Weng, S., Dhalwani, N., Griffiths, F., …Kendrick, D. (2019). Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials. Diabetic Medicine, https://doi.org/10.1111/dme.14193

Introduction: The worldwide prevalence of type 2 diabetes mellitus (T2DM) is increasing with most individuals being overweight or obese. Weight loss can reduce disease-related morbidity and mortality, and weight losses of 10-15Kg have been shown to... Read More about Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials.

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort (2019)
Journal Article
Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., …Kontopantelis, E. (2019). The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, 17(1), doi:10.1186/s12916-019-1373-y

Background: The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aims of this study are to quanti... Read More about The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort.

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Iyen, B., Qureshi, N., Leonardi-Bee, J., Kai, J., Akyea, R. K., Roderick, P., …Weng, S. (2019). Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study. Atherosclerosis, 287, 8-15. doi:10.1016/j.atherosclerosis.2019.05.017

Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More about Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (2019)
Journal Article
Ing Lee, S., Patel, M., Dutton, B., Weng, S., Luveta, J., & Qureshi, N. (2019). Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review. Journal of Community Genetics, doi:10.1007/s12687-019-00419-6

This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary careto improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane l... Read More about Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review.

Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care (2019)
Journal Article
Weng, S., Kai, J., Akyea, R., & Qureshi, N. (2019). Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care. Lancet Public Health, 4(5), doi:10.1016/S2468-2667(19)30061-1

Background: The vast majority of individuals with familial hypercholesterolaemia (FH) in the general population remain unidentified worldwide. Recognising patients most at risk of having the condition, to enable targeted specialist assessment and tre... Read More about Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care.

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, 105, 975-981. doi:10.1136/heartjnl-2018-314253

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More about Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches (2019)
Journal Article
Weng, S. F., Vaz, L., Qureshi, N., & Kai, J. (2019). Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches. PLoS ONE, 14(3), 1-22. doi:10.1371/journal.pone.0214365

Background: Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes of even greater complexity, such as premature death. This stud... Read More about Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches.

Proactive assessment of obesity risk during infancy (ProAsk): a qualitative study of parents’ and professionals’ perspectives on an mHealth intervention. (2019)
Journal Article
Rose, J., Glazebrook, C., Wharrad, H., Siriwardena, A. N., Swift, J. A., Nathan, D., …Redsell, S. (2019). Proactive assessment of obesity risk during infancy (ProAsk): a qualitative study of parents’ and professionals’ perspectives on an mHealth intervention. BMC Public Health, 19, doi:10.1186/s12889-019-6616-5

Background: Prevention of childhood obesity is a public health priority. Interventions that establish healthy growth trajectories early in life promise lifelong benefits to health and wellbeing. Proactive Assessment of Obesity Risk during Infancy... Read More about Proactive assessment of obesity risk during infancy (ProAsk): a qualitative study of parents’ and professionals’ perspectives on an mHealth intervention..

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Zghebi, S. S., Rutter, M. K., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C. A., …Planner, C. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, 8(6),

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study (2018)
Journal Article
Weng, S., Kai, J., Tranter, J., Leonardi-Bee, J., & Qureshi, N. (2018). Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study. Atherosclerosis, 274, 54-60. doi:10.1016/j.atherosclerosis.2018.04.037

Background and Aims: Familial hypercholesterolaemia (FH) is a major cause of premature heart disease but remains unrecognised in most patients. This study investigated if a systematic primary care-based approach to identify and manage possible FH imp... Read More about Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study.

Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings (2018)
Journal Article
Qureshi, N., Weng, S. F., Tranter, J. A., Da Silva, M. L., Kai, J., & Leonardi-Bee, J. (2018). Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings. Cochrane Database of Systematic Reviews, 3, doi:10.1002/14651858.CD012985

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The purpose of this review is to assess the effectiveness of interventions to systematically improve identification of FH in non-specialist settings compared t... Read More about Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2018)
Journal Article
Hussein, N., Weng, S. F., Kai, J., Kleijnen, J., & Qureshi, N. (2018). Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease. Cochrane Database of Systematic Reviews, 2015(8), doi:10.1002/14651858.CD010849.pub3

Background: Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rate... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Using interactive digital technology to predict and prevent childhood overweight (2017)
Journal Article
Rose, J., Redsell, S. A., Wharrad, H., Siriwardena, A. N., Swift, J. A., Dilip, N., …Glazebrook, C. (in press). Using interactive digital technology to predict and prevent childhood overweight. Acta Paediatrica, 106(S470), doi:10.1111/apa.14093

Background: Obesity risk factors can be identified during infancy, providing an opportunity for early intervention. ProAsk is an interactive digital intervention that supports health professionals to quantify and communicate an infant's overweight ri... Read More about Using interactive digital technology to predict and prevent childhood overweight.

Digital technology to facilitate Proactive Assessment of Obesity Risk during Infancy (ProAsk): a feasibility study (2017)
Journal Article
Redsell, S. A., Rose, J., Weng, S., Ablewhite, J., Swift, J. A., Siriwardena, A. N., …Glazebrook, C. (2017). Digital technology to facilitate Proactive Assessment of Obesity Risk during Infancy (ProAsk): a feasibility study. BMJ Open, 7, doi:10.1136/bmjopen-2017-017694

Objective: To assess the feasibility and acceptability of using digital technology for Proactive Assessment of Obesity Risk during Infancy (ProAsk) with the UK health visitors (HVs) and parents. Design: Multicentre, pre- and post-intervention feas... Read More about Digital technology to facilitate Proactive Assessment of Obesity Risk during Infancy (ProAsk): a feasibility study.