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n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids (2018)
Journal Article
Alharthi, N., Christensen, P., Hourani, W., Ortori, C., Barrett, D. A., Bennett, A. J., …Alexander, S. P. (2018). n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1863(11), (1433-1440). doi:10.1016/j.bbalip.2018.08.003. ISSN 1388-1981

Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd... Read More about n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential (2018)
Journal Article
Hourani, W., & Alexander, S. P. H. (2018). Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential. Brain and Neuroscience Advances, 2, doi:10.1177/2398212818783908. ISSN 2398-2128

Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of Cannabis administration on mental states, the CNS impact of the endocannabinoid system has been... Read More about Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential.

Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase (2018)
Journal Article
Donovan, J., Wong, P., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (in press). Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase. Acta Physiologica, doi:10.1111/apha.13126

Aim: Hypoxia causes vasodilatation of coronary arteries which protects the heart from ischaemic damage through mechanisms including the generation of hydrogen sulfide (H2S), but the influence of the perivascular adipose tissue (PVAT) and myocardium i... Read More about Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase.

A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery (2017)
Journal Article
Donovan, J., Wong, P., Roberts, R. E., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (2017). A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular Pharmacology, 93-95, doi:10.1016/j.vph.2017.05.004

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2S) is reported to be an oxygen sensor/transducer in the vasculatu... Read More about A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.

Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia (2016)
Journal Article
Gaskin, P. L., Toledo-Rodriguez, M., Alexander, S. P., & Fone, K. C. (in press). Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. International Journal of Neuropsychopharmacology, doi:10.1093/ijnp/pyw062

Background: Dysfunction of dopaminergic, GABAergic and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP) and post-weaning soci... Read More about Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article
Alefishat, E., Alexander, S. P., & Ralevic, V. (2015). Effects of NAD at purine receptors in isolated blood vessels. Purinergic Signalling, 11(1), doi:10.1007/s11302-014-9428-1

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, doi:10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat (2014)
Journal Article
Gaskin, P. L., Fone, K., & Alexander, S. (2014). Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology, 231(12), 2533-2545. https://doi.org/10.1007/s00213-013-3424-y

Rationale: Schizophrenia is a debilitating disorder comprising positive, negative and cognitive deficits with a poorly defined neurobiological aetiology; therefore, animal models with greater translational reliability are essential to develop improve... Read More about Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat.


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