Research Repository

See what's under the surface


Low molecular weight nucleoside gelators: a platform for protein aggregation inhibition (2018)
Journal Article
Johnson, L., Faidra Angelerou, M. G., Surikutchi, B. T., Allen, S., Zelzer, M., & Marlow, M. (2018). Low molecular weight nucleoside gelators: a platform for protein aggregation inhibition. Molecular Pharmaceutics, doi:10.1021/acs.molpharmaceut.8b01013

Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibition has no... Read More

The effect of protein concentration on the viscosity of a recombinant albumin solution formulation (2016)
Journal Article
Gonçalves, A. D., Alexander, C., Roberts, C. J., Spain, S. G., Uddin, S., & Allen, S. (2016). The effect of protein concentration on the viscosity of a recombinant albumin solution formulation. RSC Advances, 6(18), 15143-15154. doi:10.1039/c5ra21068b

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied. The level of protein aggregation with concentration and its impact on solution viscosit... Read More

Precision assembly of complex cellular microenvironments using holographic optical tweezers (2015)
Journal Article
Kirkham, G. R., Britchford, E., Upton, T., Ware, J., Gibson, G., Devaud, Y., …Shakesheff, K. M. (2015). Precision assembly of complex cellular microenvironments using holographic optical tweezers. Scientific Reports, 5, doi:10.1038/srep08577. ISSN 2045-2322

The accurate study of cellular microenvironments is limited by the lack of technologies that can manipulate cells in 3D at a sufficiently small length scale. The ability to build and manipulate multicellular microscopic structures will facilitate a m... Read More

Analysis of leaf surfaces using scanning ion conductance microscopy (2015)
Journal Article
Walker, S. C., Allen, S., Bell, G., & Roberts, C. J. (2015). Analysis of leaf surfaces using scanning ion conductance microscopy. Journal of Microscopy, 258(2), doi:10.1111/jmi.12225. ISSN 0022-2720

Leaf surfaces are highly complex functional systems with well defined chemistry and structure dictating the barrier and transport properties of the leaf cuticle. It is a significant imaging challenge to analyse the very thin and often complex wax-lik... Read More

Study of NAP adsorption and assembly on the surface of HOPG (2014)
Journal Article
Korolkov, V. V., Allen, S., Roberts, C. J., Gozes, I., & Tendler, S. J. (2014). Study of NAP adsorption and assembly on the surface of HOPG. Peptides, 62, doi:10.1016/j.peptides.2014.09.017. ISSN 0196-9781

NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here... Read More

The Bacillus subtilis primosomal protein DnaD untwists supercoiled DNA (2006)
Journal Article
Zhang, W., Allen, S., Roberts, C. J., & Soultanas, P. (2006). The Bacillus subtilis primosomal protein DnaD untwists supercoiled DNA. Journal of Bacteriology, 188(15), doi:10.1128/JB.00339-06. ISSN 0021-9193

The essential Bacillus subtilis DnaD and DnaB proteins have been implicated in the initiation of DNA replication. Recently, DNA remodeling activities associated with both proteins were discovered that could provide a link between global or local nucl... Read More

DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings (2004)
Journal Article
Thirlway, J., Turner, I. J., Gibson, C. T., Gardiner, L., Brady, K., Allen, S., …Soultanas, P. (2004). DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings. Nucleic Acids Research, 32(10), ISSN 0305-1048

Loading of the replicative ring helicase onto the origin of replication (oriC) is the final outcome of a well coordinated series of events that collectively constitute a primosomal cascade. Once the ring helicase is loaded, it recruits the primase an... Read More