All Outputs (72)

Objective QC for diffusion MRI data: artefact detection using normative modelling (2024)
Journal Article
Cirstian, R., Forde, N. J., Andersson, J. L., Sotiropoulos, S. N., Beckmann, C. F., & Marquand, A. F. (in press). Objective QC for diffusion MRI data: artefact detection using normative modelling. Imaging Neuroscience, https://doi.org/10.1162/imag_a_00144

Diffusion MRI is a neuroimaging modality used to evaluate brain structure at a microscopic level and can be exploited to map white matter fibre bundles and microstructure in the brain. One common issue is the presence of artefacts, such as acquisitio... Read More about Objective QC for diffusion MRI data: artefact detection using normative modelling.

The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques (2024)
Journal Article
Howell, A. M., Warrington, S., Fonteneau, C., Cho, Y. T., Sotiropoulos, S. N., Murray, J. D., & Anticevic, A. (in press). The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques. eLife, https://doi.org/10.7554/elife.95018.1

Each cortical area has a distinct pattern of anatomical connections within the thalamus, a central subcortical structure composed of functionally and structurally distinct nuclei. Previous studies have suggested that certain cortical areas may have m... Read More about The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.

Generalising XTRACT tractography protocols across common macaque brain templates (2024)
Journal Article
Assimopoulos, S., Warrington, S., Bryant, K. L., Pszczolkowski, S., Jbabdi, S., Mars, R. B., & Sotiropoulos, S. N. (2024). Generalising XTRACT tractography protocols across common macaque brain templates. Brain Structure and Function, https://doi.org/10.1007/s00429-024-02760-0

Non-human primates are extensively used in neuroscience research as models of the human brain, with the rhesus macaque being a prominent example. We have previously introduced a set of tractography protocols (XTRACT) for reconstructing 42 correspondi... Read More about Generalising XTRACT tractography protocols across common macaque brain templates.

On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations (2024)
Journal Article
Helmer, M., Warrington, S., Mohammadi-Nejad, A., Ji, J. L., Howell, A., Rosand, B., …Murray, J. D. (2024). On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations. Communications Biology, 7(1), Article 217. https://doi.org/10.1038/s42003-024-05869-4

Associations between datasets can be discovered through multivariate methods like Canonical Correlation Analysis (CCA) or Partial Least Squares (PLS). A requisite property for interpretability and generalizability of CCA/PLS associations is stability... Read More about On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations.

Denoising Diffusion MRI: Considerations and implications for analysis (2023)
Journal Article
Manzano-Patron, J., Moeller, S., Andersson, J. L. R., Ugurbil, K., Yacoub, E., & Sotiropoulos, S. N. (2024). Denoising Diffusion MRI: Considerations and implications for analysis. Imaging Neuroscience, 2, 1-29. https://doi.org/10.1101/2023.07.24.550348

Development of diffusion MRI (dMRI) denoising approaches has experienced considerable growth over the last years. As noise can inherently reduce accuracy and precision in measurements, its effects have been well characterised both in terms of uncerta... Read More about Denoising Diffusion MRI: Considerations and implications for analysis.

A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches (2023)
Journal Article
Warrington, S., Ntata, A., Mougin, O., Campbell, J., Torchi, A., Craig, M., …Sotiropoulos, S. N. (2023). A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches. Imaging Neuroscience, 1(2023), 1-27. https://doi.org/10.1162/imag_a_00042

Despite the huge potential of magnetic resonance imaging (MRI) in mapping and exploring the brain, MRI measures can often be limited in their consistency, reproducibility and accuracy which subsequently restricts their quantifiability. Nuisance nonbi... Read More about A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches.

Non-reversibility outperforms functional connectivity in characterisation of brain states in MEG data (2023)
Journal Article
Tewarie, P. K., Hindriks, R., Lai, Y. M., Sotiropoulos, S. N., Kringelbach, M., & Deco, G. (2023). Non-reversibility outperforms functional connectivity in characterisation of brain states in MEG data. NeuroImage, 276, Article 120186. https://doi.org/10.1016/j.neuroimage.2023.120186

Characterising brain states during tasks is common practice for many neuroscientific experiments using electrophysiological modalities such as electroencephalography (EEG) and magnetoencephalography (MEG). Brain states are often described in terms of... Read More about Non-reversibility outperforms functional connectivity in characterisation of brain states in MEG data.

QuNex – An Integrative Platform for Reproducible Neuroimaging Analytics (2023)
Journal Article
Ji, J. L., Demšar, J., Fonteneau, C., Tamayo, Z., Pan, L., Kraljič, A., …Repovš, G. (2023). QuNex – An Integrative Platform for Reproducible Neuroimaging Analytics. Frontiers in Neuroinformatics, 17, Article 1104508. https://doi.org/10.1101/2022.06.03.494750

Introduction: Neuroimaging technology has experienced explosive growth and transformed the study of neural mechanisms across health and disease. However, given the diversity of sophisticated tools for handling neuroimaging data, the field faces chall... Read More about QuNex – An Integrative Platform for Reproducible Neuroimaging Analytics.

Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity (2022)
Journal Article
Iwabuchi, S. J., Drabek, M. M., Cottam, W. J., Tadjibaev, A., Mohammadi-Nejad, A. R., Sotiropoulos, S., …Auer, D. P. (2022). Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity. European Journal of Neuroscience, 57(2), 373-387. https://doi.org/10.1111/ejn.15880

The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to inv... Read More about Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk (2022)
Journal Article
Mohammadi-Nejad, A. R., Allen, R. J., Kraven, L. M., Leavy, O. C., Jenkins, R. G., Wain, L. V., …Sotiropoulos, S. N. (2022). Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk. EBioMedicine, 86, Article 104356. https://doi.org/10.1016/j.ebiom.2022.104356

Background: Idiopathic pulmonary fibrosis (IPF) is a serious disease of the lung parenchyma. It has a known polygenetic risk, with at least seventeen regions of the genome implicated to date. Growing evidence suggests linked multimorbidity of IPF wit... Read More about Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk.

Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications (2022)
Journal Article
Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. (2022). Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications. Science Advances, 8(42), Article eabq2. https://doi.org/10.1126/sciadv.abq2022

Developmental and evolutionary effects on brain organization are complex, yet linked, as evidenced by the correspondence in cortical area expansion across these vastly different time scales. However, it is still not possible to study concurrently the... Read More about Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications.

White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging (2022)
Working Paper
Alotaibi, A., Podlasek, A., AlTokhis, A., Tench, C. R., Mohammadi-Nejad, A., Sotiropoulos, S. N., …Dineen, R. A. White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging

Background: Type 2 diabetes mellitus impacts the brain microstructural environment. Diffusion tensor imaging (DTI) has been widely used to characterize white matter microstructural abnormalities in type 2 diabetes but fails to fully characterise dise... Read More about White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.

Predicting time-resolved electrophysiological brain networks from structural eigenmodes (2022)
Journal Article
Tewarie, P., Prasse, B., Meier, J., Mandke, K., Warrington, S., Stam, C. J., …Hillebrand, A. (2022). Predicting time-resolved electrophysiological brain networks from structural eigenmodes. Human Brain Mapping, https://doi.org/10.1002/hbm.25967

How temporal modulations in functional interactions are shaped by the underlying anatomical connections remains an open question. Here, we analyse the role of structural eigenmodes, in the formation and dissolution of temporally evolving functional b... Read More about Predicting time-resolved electrophysiological brain networks from structural eigenmodes.

The Developing Human Connectome Project Neonatal Data Release (2022)
Journal Article
Edwards, A. D., Rueckert, D., Smith, S. M., Seada, S. A., Alansary, A., Almalbis, J., …Hajnal, J. V. (2022). The Developing Human Connectome Project Neonatal Data Release. Frontiers in Neuroscience, 16, Article 886772. https://doi.org/10.3389/fnins.2022.886772

The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It has collected 1228 multimodal magnetic res... Read More about The Developing Human Connectome Project Neonatal Data Release.

Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments (2022)
Journal Article
Brosnan, M. B., Shalev, N., Ramduny, J., Sotiropoulos, S. N., & Chechlacz, M. (2022). Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments. Brain Communications, 4(2), Article fcac080. https://doi.org/10.1093/braincomms/fcac080

Exposure to enriched environments throughout a lifetime, providing so-called reserve, protects against cognitive decline in later years. It has been hypothesized that high levels of alertness necessitated by enriched environments might strengthen the... Read More about Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments.

The association between inadequate sleep and accelerated brain ageing (2022)
Journal Article
Ramduny, J., Bastiani, M., Huedepohl, R., Sotiropoulos, S. N., & Chechlacz, M. (2022). The association between inadequate sleep and accelerated brain ageing. Neurobiology of Aging, 114, 1-14. https://doi.org/10.1016/j.neurobiolaging.2022.02.005

Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported fin... Read More about The association between inadequate sleep and accelerated brain ageing.

Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space (2022)
Working Paper
Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space

Developmental and evolutionary effects on brain organisation are complex, yet linked, as evidenced by the striking correspondence in cortical expansion changes. However, it is still not possible to study concurrently the ontogeny and phylogeny of cor... Read More about Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space.

Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment (2022)
Journal Article
Meng, D., Mohammadi-Nejad, A. R., Sotiropoulos, S. N., & Auer, D. P. (2022). Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment. European Journal of Neurology, https://doi.org/10.1111/ene.15251

Background and purpose: Anticholinergic (AC) medication use is associated with cognitive decline and dementia, which may be related to an AC-induced central hypocholinergic state, but the exact mechanisms remain to be understood. We aimed to further... Read More about Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment.

Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment (2022)
Journal Article
Meng, D., Mohammadi-Nejad, A., Sotiropoulos, S. N., & Auer, D. P. (2022). Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment. European Journal of Neurology, 29(5), 1344-1353. https://doi.org/10.1111/ene.15251

Background Anticholinergic (AC) medication use is associated with cognitive decline and dementia, which may be related to an AC induced central hypocholinergic state, but the exact mechanisms remain to be understood. We aimed to further elucidate th... Read More about Anticholinergic drugs and forebrain magnetic resonance imaging changes in cognitively normal people and those with mild cognitive impairment.

Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features (2022)
Journal Article
Hall, G. R., Boehm-Sturm, P., Dirnagl, U., Finke, C., Foddis, M., Harms, C., …Farr, T. D. (2022). Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features. Stroke, 53(5), 1735-1745. https://doi.org/10.1161/STROKEAHA.121.036997

Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, b... Read More about Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features.