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The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration (2022)
Journal Article
Almousa, L. A., Salter, A. M., Castellanos, M., May, S. T., & Langley-Evans, S. C. (2022). The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration. Nutrients, 14(17), Article 3586. https://doi.org/10.3390/nu14173586

Vascular endothelial cells have a critical role in the maintenance of cardiovascular function. Evidence suggests that endothelial function may be compromised under conditions of magnesium deficiency, which increases vulnerability to inflammation. Who... Read More about The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration.

Early life programming of health and disease: The long-term consequences of obesity in pregnancy (2022)
Journal Article
Langley-Evans, S. C. (2022). Early life programming of health and disease: The long-term consequences of obesity in pregnancy. Journal of Human Nutrition and Dietetics, 35(5), 816-832. https://doi.org/10.1111/jhn.13023

The prevalence of overweight and obesity is rising in all parts of the world and, among young women, it presents a very clear danger during pregnancy. Women who are overweight or who gain excessive weight during pregnancy are at greater risk of compl... Read More about Early life programming of health and disease: The long-term consequences of obesity in pregnancy.

Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022)
Journal Article
Langley-Evans, S. C., Pearce, J., & Ellis, S. (2022). Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review. Journal of Human Nutrition and Dietetics, 35(2), 250-264. https://doi.org/10.1111/jhn.12999

The global prevalence of overweight and obesity in pregnancy is rising and this represents a significant challenge for the management of pregnancy and delivery. Women who have a pre-pregnancy body mass index greater than 25 kgm–2 are more likely than... Read More about Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review.

Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry (2022)
Journal Article
Sach, F., Fields, L., Chenery, S., Yon, L., Henley, M. D., Buss, P., …Watts, M. J. (2023). Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry. Environmental Geochemistry and Health, 45(4), 1153-1164. https://doi.org/10.1007/s10653-022-01207-x

This paper evaluated analytical methods used to generate time-series data from elephant tail hairs, which can be used to reflect changing exposure to environmental geochemistry. Elephant tail hairs were analysed by three methods sequentially, each pr... Read More about Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Comparison of food and nutrient intake in infants aged 6–12 months, following baby-led or traditional weaning: A cross-sectional study (2021)
Journal Article
Pearce, J., & Langley-Evans, S. C. (2022). Comparison of food and nutrient intake in infants aged 6–12 months, following baby-led or traditional weaning: A cross-sectional study. Journal of Human Nutrition and Dietetics, 35(2), 310-324. https://doi.org/10.1111/jhn.12947

Background: A baby-led approach to weaning (BLW) encompasses self-feeding and self-selecting graspable foods, offering an alternative to traditional weaning (TW). This cross-sectional study explored adherence to characteristics of BLW and differences... Read More about Comparison of food and nutrient intake in infants aged 6–12 months, following baby-led or traditional weaning: A cross-sectional study.

Acute changes to breast milk composition following consumption of high-fat and high-sugar meals (2021)
Journal Article
Ward, E., Yang, N., Muhlhausler, B. S., Leghi, G. E., Netting, M. J., Elmes, M. J., & Langley-Evans, S. C. (2021). Acute changes to breast milk composition following consumption of high-fat and high-sugar meals. Maternal and Child Nutrition, 17(3), Article e13168. https://doi.org/10.1111/mcn.13168

© 2021 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. Breast milk composition is influenced by habitual diet, yet little is known about the short-term effects of changes in maternal diet on breast milk macronutrient c... Read More about Acute changes to breast milk composition following consumption of high-fat and high-sugar meals.

Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats (2020)
Journal Article
Wait, J., Burns, C., Jones, T., Harper, Z., Allen, E., Langley-Evans, S. C., & Voigt, J. (2021). Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats. Developmental Psychobiology, 63(3), 572-581. https://doi.org/10.1002/dev.22063

The cafeteria diet (CD), an experimental diet that mimics the obesogenic Western diet, can impair memory in adult rats. However, the suckling period is also particularly susceptible to diet?induced behavioural modification. Here, following exposure t... Read More about Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats.

Nutrition, growth, and other factors associated with early cognitive and motor development in Sub-Saharan Africa: a scoping review (2020)
Journal Article
Pitchford, N. J., Outhwaite, L. A., French, B., Langley-Evans, S. C., French, B., Outhwaite, L. A., & Pitchford, N. J. (2020). Nutrition, growth, and other factors associated with early cognitive and motor development in Sub-Saharan Africa: a scoping review. Journal of Human Nutrition and Dietetics, https://doi.org/10.1111/jhn.12795

© 2020 The British Dietetic Association Ltd. Background: Food insecurity, poverty and exposure to infectious disease are well-established drivers of malnutrition in children in Sub-Saharan Africa. Early development of cognitive and motor skills – the... Read More about Nutrition, growth, and other factors associated with early cognitive and motor development in Sub-Saharan Africa: a scoping review.

Potential bio-indicators for assessment of mineral status in elephants (2020)
Journal Article
Sach, F., Dierenfeld, E. S., Langley-Evans, S. C., Hamilton, E., Lark, R. M., Yon, L., & Watts, M. J. (2020). Potential bio-indicators for assessment of mineral status in elephants. Scientific Reports, 10, https://doi.org/10.1038/s41598-020-64780-0

© 2020, The Author(s). The aim of this study was two-fold: (1) identify suitable bio-indicators to assess elemental status in elephants using captive elephant samples, and (2) understand how geochemistry influences mineral intake. Tail hair, toenail,... Read More about Potential bio-indicators for assessment of mineral status in elephants.

Spatial geochemistry influences the home range of elephants (2020)
Journal Article
Sach, F., Yon, L., Henley, M. D., Bedetti, A., Buss, P., de Boer, W. F., …Watts, M. J. (2020). Spatial geochemistry influences the home range of elephants. Science of the Total Environment, 729, Article 139066. https://doi.org/10.1016/j.scitotenv.2020.139066

© 2020 Elsevier B.V. The unique geochemistry surrounding the Palabora Mining Company (PMC) land may act as a micronutrient hotspot, attracting elephants to the area. The PMC produces refined copper and extracts phosphates and other minerals. Understa... Read More about Spatial geochemistry influences the home range of elephants.

The effect of maternal dietary fat content and omega-6 to omega-3 ratio on offspring growth and hepatic gene expression in the rat (2020)
Journal Article
Draycott, S. A., George, G., Elmes, M. J., Muhlhausler, B. S., & Langley-Evans, S. C. (2020). The effect of maternal dietary fat content and omega-6 to omega-3 ratio on offspring growth and hepatic gene expression in the rat. British Journal of Nutrition, 123(11), 1227-1238. https://doi.org/10.1017/S000711452000046X

© The Authors 2020. Omega-6 fatty acids have been shown to exert pro-adipogenic effects whereas omega-3 fatty acids work in opposition. Increasing intakes of LA (linoleic acid; omega-6) vs ALA (alpha-linolenic acid; omega-3) in Western diets has led... Read More about The effect of maternal dietary fat content and omega-6 to omega-3 ratio on offspring growth and hepatic gene expression in the rat.

Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial (2019)
Journal Article
Joy, E. J., Kalimbira, A. A., Gashu, D., Ferguson, E. L., Sturgess, J., Dangour, A. D., …Allen, E. (2019). Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial. Trials, 20(1), Article 795. https://doi.org/10.1186/s13063-019-3894-2

© 2019 The Author(s). Background: Micronutrient deficiencies including selenium (Se) are widespread in Malawi and potentially underlie a substantial disease burden, particularly among poorer and marginalised populations. Concentrations of Se in stapl... Read More about Can selenium deficiency in Malawi be alleviated through consumption of agro-biofortified maize flour? Study protocol for a randomised, double-blind, controlled trial.

Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet (2019)
Journal Article
Draycott, S. A., Daniel, Z., Khan, R., Muhlhausler, B. S., & Langley-Evans, S. C. (2019). Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet. Journal of Developmental Origins of Health and Disease, 11(3), 222-227. https://doi.org/10.1017/S2040174419000606

Evidence suggests that sub-optimal maternal nutrition has implications for the developing offspring. We have previously shown that exposure to a low-protein diet during gestation was associated with upregulation of genes associated with cholesterol t... Read More about Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet.

The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning (2019)
Journal Article
George, G., Draycott, S. A., Muir, R., Clifford, B., Elmes, M. J., & Langley-Evans, S. C. (2019). The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning. Scientific Reports, 9, Article 14173. https://doi.org/10.1038/s41598-019-50448-x

Exposure to maternal obesity during early-life can have adverse consequences for offspring growth and adiposity. We aimed to assess the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria diet, during pregnanc... Read More about The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning.

Exposure to maternal obesity during suckling outweighs in utero exposure in programming for post-weaning adiposity and insulin resistance in rats (2019)
Journal Article
George, G., Draycott, S. A., Muir, R., Clifford, B., Elmes, M. J., & Langley-Evans, S. C. (2019). Exposure to maternal obesity during suckling outweighs in utero exposure in programming for post-weaning adiposity and insulin resistance in rats. Scientific Reports, 9(1), 1-10. https://doi.org/10.1038/s41598-019-46518-9

Exposure to maternal obesity during early development programmes adverse metabolic health in rodent offspring. We assessed the relative contributions of obesity during pregnancy and suckling on metabolic health post-weaning. Wistar rat offspring expo... Read More about Exposure to maternal obesity during suckling outweighs in utero exposure in programming for post-weaning adiposity and insulin resistance in rats.

Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats (2019)
Journal Article
Moreton, E., Baron, P., Tiplady, S., McCall, S., Clifford, B., Langley-Evans, S. C., …Voigt, J. P. (2019). Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats. Behavioural Brain Research, 363, 191-198. https://doi.org/10.1016/j.bbr.2019.02.003

© 2019 Elsevier B.V. The prefrontal cortex (PFC) undergoes protracted postnatal development such that its structure and behavioural function may be profoundly altered by environmental factors. Here we investigate the effect of lactational dietary man... Read More about Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats.

African savanna elephants (Loxodonta africana) as an example of a herbivore making movement choices based on nutritional needs (2019)
Journal Article
Sach, F., Dierenfeld, E. S., Langley-Evans, S. C., Watts, M. J., & Yon, L. (2019). African savanna elephants (Loxodonta africana) as an example of a herbivore making movement choices based on nutritional needs. PeerJ, 7, https://doi.org/10.7717/peerj.6260

© 2019 Sach et al. Background: The increasing human population and global intensification of agriculture have had a major impact on the world’s natural ecosystems and caused devastating effects on populations of mega-herbivores such as the African sa... Read More about African savanna elephants (Loxodonta africana) as an example of a herbivore making movement choices based on nutritional needs.

Maternal dietary ratio of linoleic acid to alpha-linolenic acid during pregnancy has sexspecific effects on placental and fetal weights in the rat (2019)
Journal Article
Draycott, S. A., Liu, G., Daniel, Z. C., Elmes, M. J., Mulhausler, B. S., & Langley-Evans, S. C. (2019). Maternal dietary ratio of linoleic acid to alpha-linolenic acid during pregnancy has sexspecific effects on placental and fetal weights in the rat. Nutrition and Metabolism, 16(1), https://doi.org/10.1186/s12986-018-0330-7

Background: Increased consumption of linoleic acid (LA, omega-6) in Western diets coupled with the pro-inflammatory and adipogenic properties of its derivatives has led to suggestions that fetal exposure to this dietary pattern could be contributing... Read More about Maternal dietary ratio of linoleic acid to alpha-linolenic acid during pregnancy has sexspecific effects on placental and fetal weights in the rat.

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) (2018)
Journal Article
Almousa, L. A., Salter, A. M., & Langley-Evans, S. C. (2018). Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs). Magnesium Research, 31(3), 99-109. https://doi.org/10.1684/mrh.2018.0439

The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain... Read More about Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs).