Skip to main content

Research Repository

Advanced Search

All Outputs (7)

Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens (2020)
Journal Article
Vallières, C., Singh, N., Alexander, C., & Avery, S. V. (2020). Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens. ACS Infectious Diseases, 6(11), 2950-2958. https://doi.org/10.1021/acsinfecdis.0c00405

With the spread of drug resistance, new antimicrobials are urgently needed. Here, we set out to tackle this problem by high-throughput exploration for novel antifungal synergies among combinations of approved, nonantifungal drugs; a novel strategy ex... Read More about Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens.

Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments. Computational and Structural Biotechnology Journal, 18, 2860-2866. https://doi.org/10.1016/j.csbj.2020.09.030

© 2020 The Author(s) Spatial structure over scales ranging from nanometres to centimetres (and beyond) varies markedly in diverse habitats and the industry-relevant settings that support microbial activity. Developing an understanding of the interpla... Read More about Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments.

Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action (2020)
Journal Article
Wohlgemuth, F., Gomes, R. L., Singleton, I., Rawson, F. J., & Avery, S. V. (2020). Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action. Frontiers in Microbiology, 11, Article 575157. https://doi.org/10.3389/fmicb.2020.575157

© Copyright © 2020 Wohlgemuth, Gomes, Singleton, Rawson and Avery. We developed a top-down strategy to characterize an antimicrobial, oxidizing sanitizer, which has diverse proposed applications including surface-sanitization of fresh foods, and with... Read More about Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action.

Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats. Soil Biology and Biochemistry, 148, https://doi.org/10.1016/j.soilbio.2020.107870

Differences in the structure of microbial communities are reported to exist between the inside and outside of soil aggregates, but the impacts of soil aggregation on microbial activity in soils, essential for soil health, have proven difficult to stu... Read More about Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats.

Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration (2020)
Journal Article
Vallieres, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G., Davies, C. R., …Avery, S. V. (2020). Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances, 6(23), Article eaba6574. https://doi.org/10.1126/sciadv.aba6574

© 2020 The Authors. Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passivel... Read More about Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration.

The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species (2020)
Journal Article
Stratford, M., Vallières, C., Geoghegan, I. A., Archer, D. B., & Avery, S. V. (2020). The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species. mSphere, 5(3), https://doi.org/10.1128/mSphere.00273-20

Copyright © 2020 Stratford et al. A small number (10 to 20) of yeast species cause major spoilage in foods. Spoilage yeasts of soft drinks are resistant to preservatives like sorbic acid, and they are highly fermentative, generating large amounts of... Read More about The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species.

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article
Geoghegan, I. A., Stratford, M., Bromley, M., Archer, D. B., & Avery, S. V. (2020). Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger. mSphere, 5(1), https://doi.org/10.1128/msphere.00685-19

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.