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A facile one step route that introduces functionality to polymer powders for laser sintering (2024)
Journal Article
Krumins, E., Crawford, L. A., Rogers, D. M., Machado, F., Taresco, V., East, M., …Howdle, S. M. (2024). A facile one step route that introduces functionality to polymer powders for laser sintering. Nature Communications, 15(1), Article 3137. https://doi.org/10.1038/s41467-024-47376-4

Laser Sintering (LS) is a type of Additive Manufacturing (AM) exploiting laser processing of polymeric particles to produce 3D objects. Because of its ease of processability and thermo-physical properties, polyamide-12 (PA-12) represents ~95% of the... Read More about A facile one step route that introduces functionality to polymer powders for laser sintering.

A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection (2023)
Journal Article
Crawford, L. A., Cuzzucoli Crucitti, V., Stimpson, A., Morgan, C., Blake, J., Wildman, R. D., …Avery, S. V. (2023). A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection. Green Chemistry, 25(21), 8558-8569. https://doi.org/10.1039/d3gc01911j

Fungicidal compounds are actives widely used for crop protection from fungal infection, but they can also kill beneficial organisms, enter the food chain and promote resistant pathogen strains from overuse. Here we report the first field crop trial o... Read More about A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection.

Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids (2023)
Journal Article
Kalli, S., Vallieres, C., Violet, J., Sanders, J., Chapman, J., Vincken, J., …Araya-Cloutier, C. (2023). Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids. Microbiology Spectrum, 11(4), Article e0132723. https://doi.org/10.1128/spectrum.01327-23

Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which l... Read More about Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids.

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1 (2023)
Journal Article
Amambua-Ngwa, A., Button-Simons, K. A., Li, X., Kumar, S., Brenneman, K. V., Ferrari, M., …Anderson, T. J. (2023). Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nature Microbiology, https://doi.org/10.1038/s41564-023-01377-z

Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations... Read More about Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.

Evaluating the potential of natural product combinations with sorbic acid for improving preservative action against food-spoilage yeasts (2023)
Journal Article
Harvey, H. J., Hendry, A. C., Archer, D. B., & Avery, S. V. (2023). Evaluating the potential of natural product combinations with sorbic acid for improving preservative action against food-spoilage yeasts. Fungal Biology, 127(7-8), 1218-1223. https://doi.org/10.1016/j.funbio.2023.01.004

Fungal control methods commonly involve the use of antifungals or preservatives, which can raise concerns about broader effects of these stressors on non-target organisms, spread of resistance and regulatory hurdles. Consequently, control methods ena... Read More about Evaluating the potential of natural product combinations with sorbic acid for improving preservative action against food-spoilage yeasts.

Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy (2022)
Journal Article
Augostine, C. R., & Avery, S. V. (2022). Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy. Frontiers in Microbiology, 13, Article 866840. https://doi.org/10.3389/fmicb.2022.866840

The growing prevalence of antifungal drug resistance coupled with the slow development of new, acceptable drugs and fungicides has raised interest in natural products (NPs) for their therapeutic potential and level of acceptability. However, a number... Read More about Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy.

Application of microfluidic systems in modelling impacts of environmental structure on stress-sensing by individual microbial cells (2021)
Journal Article
Harvey, H. J., Chubynsky, M. V., Sprittles, J. E., Shor, L. M., Mooney, S. J., Wildman, R. D., & Avery, S. V. (2022). Application of microfluidic systems in modelling impacts of environmental structure on stress-sensing by individual microbial cells. Computational and Structural Biotechnology Journal, 20, 128-138. https://doi.org/10.1016/j.csbj.2021.11.039

Environmental structure describes physical structure that can determine heterogenous spatial distribution of biotic and abiotic (nutrients, stressors etc.) components of a microorganism's microenvironment. This study investigated the impact of microm... Read More about Application of microfluidic systems in modelling impacts of environmental structure on stress-sensing by individual microbial cells.

Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size (2021)
Journal Article
Harvey, H. J., Mitzakoff, A. M., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2021). Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size. Applied and Environmental Microbiology, 87(20), Article e01005-21. https://doi.org/10.1128/AEM.01005-21

The physical environments in which microorganisms naturally reside rarely have homogeneous structure, and changes in their porous architecture may have effects on microbial activities that are not typically captured in conventional laboratory studies... Read More about Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size.

Inkjet 3D Printing of Polymers Resistant to Fungal Attachment (2021)
Journal Article
He, Y., Vallières, C., Alexander, M. R., Wildman, R. D., & Avery, S. V. (2021). Inkjet 3D Printing of Polymers Resistant to Fungal Attachment. Bio-protocol, 11(9), Article e4016. https://doi.org/10.21769/BioProtoc.4016

Inkjet 3D printing is an additive manufacturing method that allows the user to produce a small batch of customized devices for comparative study versus commercial products. Here, we describe the use of a commercial 2D ink development system (Dimatix... Read More about Inkjet 3D Printing of Polymers Resistant to Fungal Attachment.

Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations (2021)
Journal Article
Vallières, C., Alexander, C., & Avery, S. V. (2021). Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations. Applied Microbiology and Biotechnology, 105, 2867-2875. https://doi.org/10.1007/s00253-021-11211-3

Fungi cause diverse, serious socio-economic problems, including biodeterioration of valuable products and materials that spawns a biocides industry worth ~$11 billion globally. To help combat environmental fungi that commonly colonise material produc... Read More about Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations.

Influence of environmental and genetic factors on food protein quality: current knowledge and future directions (2021)
Journal Article
Szepe, K. J., Dyer, P. S., Johnson, R. I., Salter, A. M., & Avery, S. V. (2021). Influence of environmental and genetic factors on food protein quality: current knowledge and future directions. Current Opinion in Food Science, 40, 94-101. https://doi.org/10.1016/j.cofs.2021.02.005

© 2021 Elsevier Ltd Dietary protein quality is commonly defined by the bioavailability of essential amino acids, a function of amino acid composition and protein digestibility. This review assesses the potential for manipulation of amino acid composi... Read More about Influence of environmental and genetic factors on food protein quality: current knowledge and future directions.

Evolving challenges and strategies for fungal control in the food supply chain (2021)
Journal Article
Davies, C. R., Wohlgemuth, F., Young, T., Violet, J., Dickinson, M., Sanders, J., …Avery, S. V. (2021). Evolving challenges and strategies for fungal control in the food supply chain. Fungal Biology Reviews, 36, 15-26. https://doi.org/10.1016/j.fbr.2021.01.003

Fungi that spoil foods or infect crops can have major socioeconomic impacts, posing threats to food security. The strategies needed to manage these fungi are evolving, given the growing incidence of fungicide resistance, tightening regulations of che... Read More about Evolving challenges and strategies for fungal control in the food supply chain.

Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens (2020)
Journal Article
Vallières, C., Singh, N., Alexander, C., & Avery, S. V. (2020). Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens. ACS Infectious Diseases, 6(11), 2950-2958. https://doi.org/10.1021/acsinfecdis.0c00405

With the spread of drug resistance, new antimicrobials are urgently needed. Here, we set out to tackle this problem by high-throughput exploration for novel antifungal synergies among combinations of approved, nonantifungal drugs; a novel strategy ex... Read More about Repurposing Nonantifungal Approved Drugs for Synergistic Targeting of Fungal Pathogens.

Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments. Computational and Structural Biotechnology Journal, 18, 2860-2866. https://doi.org/10.1016/j.csbj.2020.09.030

© 2020 The Author(s) Spatial structure over scales ranging from nanometres to centimetres (and beyond) varies markedly in diverse habitats and the industry-relevant settings that support microbial activity. Developing an understanding of the interpla... Read More about Challenges and approaches in assessing the interplay between microorganisms and their physical micro-environments.

Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action (2020)
Journal Article
Wohlgemuth, F., Gomes, R. L., Singleton, I., Rawson, F. J., & Avery, S. V. (2020). Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action. Frontiers in Microbiology, 11, Article 575157. https://doi.org/10.3389/fmicb.2020.575157

© Copyright © 2020 Wohlgemuth, Gomes, Singleton, Rawson and Avery. We developed a top-down strategy to characterize an antimicrobial, oxidizing sanitizer, which has diverse proposed applications including surface-sanitization of fresh foods, and with... Read More about Top-Down Characterization of an Antimicrobial Sanitizer, Leading From Quenchers of Efficacy to Mode of Action.

Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats (2020)
Journal Article
Harvey, H. J., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2020). Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats. Soil Biology and Biochemistry, 148, https://doi.org/10.1016/j.soilbio.2020.107870

Differences in the structure of microbial communities are reported to exist between the inside and outside of soil aggregates, but the impacts of soil aggregation on microbial activity in soils, essential for soil health, have proven difficult to stu... Read More about Soil aggregates by design: Manufactured aggregates with defined microbial composition for interrogating microbial activities in soil microhabitats.

Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration (2020)
Journal Article
Vallieres, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G., Davies, C. R., …Avery, S. V. (2020). Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances, 6(23), Article eaba6574. https://doi.org/10.1126/sciadv.aba6574

© 2020 The Authors. Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passivel... Read More about Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration.

The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species (2020)
Journal Article
Stratford, M., Vallières, C., Geoghegan, I. A., Archer, D. B., & Avery, S. V. (2020). The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species. mSphere, 5(3), https://doi.org/10.1128/mSphere.00273-20

Copyright © 2020 Stratford et al. A small number (10 to 20) of yeast species cause major spoilage in foods. Spoilage yeasts of soft drinks are resistant to preservatives like sorbic acid, and they are highly fermentative, generating large amounts of... Read More about The Preservative Sorbic Acid Targets Respiration, Explaining the Resistance of Fermentative Spoilage Yeast Species.

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article
Geoghegan, I. A., Stratford, M., Bromley, M., Archer, D. B., & Avery, S. V. (2020). Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger. mSphere, 5(1), https://doi.org/10.1128/msphere.00685-19

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.