Research Repository

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Fruit softening: revisiting the role of pectin (2018)
Journal Article
Wang, D., Yeats, T. H., Uluisik, S., Rose, J. K., & Seymour, G. B. (2018). Fruit softening: revisiting the role of pectin. Trends in Plant Science, 23(4), (302-310). doi:10.1016/j.tplants.2018.01.006. ISSN 1360-1385

Fruit softening is a major determinant of shelf life and commercial value. Here, we highlight recent work that revisits the role of pectin in fruit softening and primary cell wall structure. These studies demonstrate the importance of pectin and the... Read More

Scientific synergy between LSST and Euclid (2017)
Journal Article
Rhodes, J., Nichol, R. C., Aubourg, É., Bean, R., Boutigny, D., Bremer, M. N., …Linden, A. V. D. (2017). Scientific synergy between LSST and Euclid. Astrophysical Journal Supplement, 233(2), doi:10.3847/1538-4365/aa96b0. ISSN 0067-0049

Euclid and the Large Synoptic Survey Telescope (LSST) are poised to dramatically change the astronomy landscape early in the next decade. The combination of high-cadence, deep, wide-field optical photometry from LSST with high-resolution, wide-field... Read More

Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease (2017)
Journal Article
Boden, K. A., Barber, I. S., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., …Bottley, A. (2017). Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease. doi:10.3233/ADR-170015. ISSN 2542-4823

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD), however the drivers of this disease remains enigmatic. Genome wide association and in-vivo modelling have shown that loss-of-function e.g. ABCA7, reduced levels of SIRT1,... Read More

Mechanical degradation of biomass wood pellets during long term stockpile storage (2017)
Journal Article
Graham, S., Eastwick, C., Snape, C., & Quick, W. (2017). Mechanical degradation of biomass wood pellets during long term stockpile storage. Fuel Processing Technology, 160, doi:10.1016/j.fuproc.2017.02.017. ISSN 0378-3820

This paper quantifies and assesses the mechanical degradation of white wood and steam exploded wood pellets in indoor and outdoor stockpile storage over a twenty-one month period in the UK. The indoor stored steam exploded wood pellets on the surface... Read More

Genetic improvement of tomato by targeted control of fruit softening (2016)
Journal Article
Uluisik, S., Chapman, N. H., Smith, R., Poole, M., Adams, G., Gillis, R. B., …Seymour, G. B. (2016). Genetic improvement of tomato by targeted control of fruit softening. Nature Biotechnology, 34, 950-952. doi:10.1038/nbt.3602

Controlling the rate of softening to extend shelf life was a key target for researchers engineering genetically modified (GM) tomatoes in the 1990s, but only modest improvements were achieved. Hybrids grown nowadays contain 'non-ripening mutations' t... Read More

Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway? (2016)
Journal Article
Barton, N. A., Marsh, B. J., Lewis, W., Narraidoo, N., Seymour, G. B., Fray, R. G., & Hayes, C. J. (in press). Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?. Chemical Science, 7(5), doi:10.1039/c5sc03463a. ISSN 2041-6520

We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereoselective manner to provide taxadiene-4(5)-epoxide (12) as a single diastereoisomer, and that this epoxide can be rearranged to give taxa-4(20),11(12)-dien... Read More

A DEMETER-like DNA demethylase protein governs tomato fruit ripening (2015)
Journal Article
Liu, R. E., How-Kit, A., Stammitti, L., Teyssier, E., Rolin, D., Bertrand, A., …Gallusci, P. (2015). A DEMETER-like DNA demethylase protein governs tomato fruit ripening. Proceedings of the National Academy of Sciences, 112(34), doi:10.1073/pnas.1503362112

In plants, genomic DNA methylation which contributes to development and stress responses can be actively removed by DEMETER-like DNA demethylases (DML). Indeed, in Arabidopsis DMLs are important for maternal imprinting and endosperm demethylation, bu... Read More

Discrepancies between registration and publication of randomised controlled trials: an observational study (2014)
Journal Article
of randomised controlled trials: an observational study. Journal of the Royal Society of Medicine, 5(5), doi:10.1177/2042533313517688. ISSN 0141-0768

Abstract OBJECTIVES: To determine the consistency between information contained in the registration and publication of randomised controlled trials (RCTs). DESIGN: An observational study of RCTs published between May 2011 and May 2012 in the Brit... Read More

A genome-wide metabolomic resource for tomato fruit from Solanum pennellii (2014)
Journal Article
Perez-Fons, L., Wells, T., Corol, D. I., Ward, J. L., Gerrish, C., Beale, M. H., …Fraser, P. D. (in press). A genome-wide metabolomic resource for tomato fruit from Solanum pennellii. Scientific Reports, 4, doi:10.1038/srep03859. ISSN 2045-2322

Tomato and its processed products are one of the most widely consumed fruits. Its domestication, however, has resulted in the loss of some 95% of the genetic and chemical diversity of wild relatives. In order to elucidate this diversity, exploit it... Read More

Analysis of ripening-related gene expression in papaya using an Arabidopsis-based microarray (2012)
Journal Article
Fabi, J. P., Seymour, G. B., Graham, N. S., Broadley, M. R., May, S., Lajolo, F. M., …Oliveira do Nascimento, J. R. (in press). Analysis of ripening-related gene expression in papaya using an Arabidopsis-based microarray. BMC Plant Biology, 12, doi:10.1186/1471-2229-12-242. ISSN 1471-2229

Background Papaya (Carica papaya L.) is a commercially important crop that produces climacteric fruits with a soft and sweet pulp that contain a wide range of health promoting phytochemicals. Despite its importance, little is known about transcrip... Read More