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Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid (2017)
Journal Article
Rimington, T. L., Hodge, E., Billington, C. K., Bhaker, S., K C, B., Kilty, I., …Sayers, I. (2017). Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid. F1000Research, 6, doi:10.12688/f1000research.10961.1. ISSN 2046-1402

Background: Airway inflammation is a feature of many respiratory diseases and there is a need for newer, more effective anti-inflammatory compounds. The aim of this study was to develop an ex vivo human lung explant model which can be used to help st... Read More

The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro (2016)
Journal Article
Miller, S., Henry, A. P., Hodge, E., Kheirallah, A. K., Billington, C. K., Rimington, T. L., …Sayers, I. (2016). The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro. PLoS ONE, 11(10), doi:10.1371/journal.pone.0164041. ISSN 1932-6203

Introduction Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Recepto... Read More