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All Outputs (90)

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (in press). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

Objective To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Methods Adu... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study (2024)
Journal Article
Hancox, J. E., Chaplin, W. J., Hilton, C. E., Vadaszy, N., Gray, K., Game, F., & Vedhara, K. (2024). Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study. PLoS ONE, 19(2), Article e0295180. https://doi.org/10.1371/journal.pone.0295180

Patients with diabetic foot ulcers have poor adherence to treatment recommendations. However, the most effective way to support adherence in this population is unknown. This study aimed to assess the preliminary effectiveness of a motivation communic... Read More about Motivation communication training programme for healthcare professionals to support adherence in patients with diabetic foot ulcers: Proof of concept study.

Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions (2023)
Journal Article
Hancox, J., Chaplin, W., Hilton, C., Gray, K., Game, F., & Vedhara, K. (2023). Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions. Health Education and Behavior, https://doi.org/10.1177/10901981231216744

Diabetic foot ulcers (DFUs) impact a substantial proportion of patients with diabetes, with high recurrence rates, severe complications, and significant financial burden to health care systems. Adherence to treatment advice (e.g., limiting weight-bea... Read More about Development of a Motivation Communication Training to Aid Diabetes-Specialist Podiatrists With Adherence Discussions.

Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial (2023)
Journal Article
Ayling, K., Brown, M., Carlisle, S., Bennett, R., Buchanan, H., Dumbleton, J., …Vedhara, K. (2023). Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Health Psychology, 43(2), 77-88. https://doi.org/10.1037/hea0001267

Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether... Read More about Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.

The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED) (2023)
Journal Article
Lorito, C. D., Van Der Wardt, V., Pollock, K., Howe, L., Booth, V., Logan, P., …Harwood, R. H. (2023). The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED). Age and Ageing, 52(8), Article afad166. https://doi.org/10.1093/ageing/afad166

Background. The PRomoting Activity, Independence and Stability in Early Dementia (PrAISED) study delivered an exercise and functional activity programme to participants living with dementia. A Randomised Controlled Trial (RCT) showed no measurable be... Read More about The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED).

Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’ (2023)
Journal Article
Shanmugavadivel, D., Liu, J., Ball-Gamble, A., Polanco, A., Vedhara, K., Nathan, P., …Ojha, S. (2023). Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’. British Journal of General Practice, 73(733), 377-379. https://doi.org/10.3399/bjgp23x734673

In 2018, the World Health Organization declared childhood cancer as a global disease burden, launching a Global Initiative to improve survival to 60% worldwide by 2030. If achieved, it is estimated that an extra 1 million children’s lives will be sav... Read More about Childhood bone tumours in primary care: helping GPs to identify ‘the needle in the haystack’.

Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study (2023)
Journal Article
Hancox, J. E., Hilton, C., Gray, K., Game, F., & Vedhara, K. (2023). Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study. International Wound Journal, 20(10), 3945-3954. https://doi.org/10.1111/iwj.14282

Patients with diabetic foot ulcers are advised to limit weight-bearing activity for ulcers to heal. Patients often disregard this advice although the reasons are not yet fully understood. This study explored (1) patients' experiences of receiving the... Read More about Adherence to limiting weight-bearing activity in patients with diabetic foot ulcers: A qualitative study.

Influence of setting-dependent contacts and protective behaviours on asymptomatic SARS-CoV-2 infection amongst members of a UK university (2023)
Journal Article
Fairbanks, E. L., Bolton, K. J., Jia, R., Figueredo, G. P., Knight, H., & Vedhara, K. (2023). Influence of setting-dependent contacts and protective behaviours on asymptomatic SARS-CoV-2 infection amongst members of a UK university. Epidemics, 43, Article 100688. https://doi.org/10.1016/j.epidem.2023.100688

We survey 62 users of a university asymptomatic SARS-CoV-2 testing service on details of their activities, protective behaviours and contacts in the 7 days prior to receiving a positive or negative SARS-CoV-2 PCR test result in the period October 202... Read More about Influence of setting-dependent contacts and protective behaviours on asymptomatic SARS-CoV-2 infection amongst members of a UK university.

Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health (2023)
Journal Article
Jones, E. J., Ayling, K., Wiley, C. R., Geraghty, A. W., Greer, A. L., Holt-Lunstad, J., …Vedhara, K. (2023). Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health. Policy Insights from the Behavioral and Brain Sciences, 10(1), 33-40. https://doi.org/10.1177/23727322221145308

Psychosocial factors are related to immune, viral, and vaccination outcomes. Yet, this knowledge has been poorly represented in public health initiatives during the COVID-19 pandemic. This review provides an overview of biopsychosocial links relevant... Read More about Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health.

Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study (2023)
Journal Article
Graça Pereira, M., Vilaça, M., Pedras, S., Carvalho, A., Vedhara, K., Jesus Dantas, M., & Machado, L. (2023). Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study. Diabetes Research and Clinical Practice, 198, Article 110623. https://doi.org/10.1016/j.diabres.2023.110623

Aims: This study aimed to identify demographic, clinical, and psychological contributors to DFU healing and favorable healing process. Methods: Patients with a chronic DFU were evaluated at baseline (T0; n = 153), two months later (T1; n = 108), and... Read More about Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study.

Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process (2023)
Journal Article
Shanmugavadivel, D., Liu, J. F., Gamble, A., Polanco, A., Vedhara, K., Walker, D., & Ojha, S. (2023). Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process. BMJ Paediatrics Open, 7, Article e001771. https://doi.org/10.1136/bmjpo-2022-001771

Background The incidence of childhood cancer has risen by 15% since the 1990s. Early diagnosis is key to optimising outcomes, however diagnostic delays are widely reported. Presenting symptoms are often non-specific causing a diagnostic dilemma for c... Read More about Assessing and investigating children with suspected bone and abdominal tumours: an e-Delphi consensus process.

How people with knee pain understand why their pain changes or remains the same over time: A qualitative study (2023)
Journal Article
Walsh, D. A., Rathbone, J., Akin-Akinyosoye, K., Fernandes, G. S., Valdes, A. M., McWilliams, D. F., …Ferguson, E. (2023). How people with knee pain understand why their pain changes or remains the same over time: A qualitative study. Osteoarthritis and Cartilage Open, 5(2), Article 100345. https://doi.org/10.1016/j.ocarto.2023.100345

Objectives Guidelines recommend knee osteoarthritis pain management based on biopsychosocial mechanisms. Treatment adherence and effectiveness may be affected if there is a mismatch between patient perspectives and treatment focus. We therefore exam... Read More about How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.

Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study (2022)
Journal Article
Jia, R., Ayling, K., Coupland, C., Chalder, T., Massey, A., Nater, U., …Vedhara, K. (2023). Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study. Psychoneuroendocrinology, 148, Article 105992. https://doi.org/10.1016/j.psyneuen.2022.105992

Background: Research suggests that psychological factors may influence vulnerability to SARS-CoV-2 infection, although the mechanisms are unclear. Purpose: We examined whether the hypothalamic-pituitary-adrenal axis may be a possible mechanism, by me... Read More about Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., …Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study (2022)
Journal Article
Law, M., Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., …Broadbent, E. (2022). Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study. Psych, 4(4), 706-716. https://doi.org/10.3390/psych4040052

This longitudinal study investigated changes in and risk factors for anxiety and depression during the COVID-19 pandemic in a New Zealand cohort. Online surveys were distributed to 681 participants at three time-points: May 2020 (Time 1), August–Sept... Read More about Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study.

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic (2022)
Journal Article
Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J. S. N., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PLoS ONE, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

Objectives To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs). Methods Recruiting through national patient charities and a local h... Read More about Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic.

The effect of expressive writing on wound healing: Immunohistochemistry analysis of skin tissue two weeks after punch biopsy wounding (2022)
Journal Article
Robinson, H., Jarrett, P., Vedhara, K., Tarlton, J., Whiting, C., Law, M., & Broadbent, E. (2022). The effect of expressive writing on wound healing: Immunohistochemistry analysis of skin tissue two weeks after punch biopsy wounding. Journal of Psychosomatic Research, 161, Article 110987. https://doi.org/10.1016/j.jpsychores.2022.110987

Objective: To investigate the effects of expressive writing and its timing (pre or post wounding) on re-epithelialisation and leucocyte subsets within healing tissue. We previously showed expressive writing pre-wounding improved re-epithelialisation.... Read More about The effect of expressive writing on wound healing: Immunohistochemistry analysis of skin tissue two weeks after punch biopsy wounding.

Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study (2022)
Journal Article
Al-Oraibi, A., Fothergill, L., Yildirim, M., Knight, H., Carlisle, S., O’Connor, M., …Blake, H. (2022). Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study. International Journal of Environmental Research and Public Health, 19(13), Article 7631. https://doi.org/10.3390/ijerph19137631

The global COVID-19 pandemic has impacted on the mental well-being of university students, but little attention has been given to international students, who may have a unique experience and perspective. The aim of this study was to explore the views... Read More about Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study.

The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout (2022)
Journal Article
Knight, H., Jia, R., Ayling, K., Blake, H., Morling, J. R., Villalon, A. M., …Vedhara, K. (2023). The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout. Perspectives in Public Health, 143(4), 220-224. https://doi.org/10.1177/17579139221094750

Aims: Development and rollout of vaccines offers the best opportunity for population protection against the SARS-CoV-2 (COVID-19) virus. However, hesitancy towards the vaccines might impede successful uptake in the United Kingdom, particularly in you... Read More about The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout.

Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach (2022)
Journal Article
Gasteiger, N., Gasteiger, C., Vedhara, K., & Broadbent, E. (2022). Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach. Vaccine, 40(25), 3461-3465. https://doi.org/10.1016/j.vaccine.2022.04.092

Demographics and media discourse impact vaccine hesitancy. We explored the New Zealand public's perceptions of COVID-19 vaccines and associated media portrayal, and determined predictive factors associated with willingness to receive vaccines. A comm... Read More about Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach.