All Outputs (65)

Pediatric Ependymoma: Biological Perspectives (2009)
Journal Article
Kilday, J., Rahman, R., Dyer, S., Ridley, L., Lowe, J., Coyle, B., & Grundy, R. (2009). Pediatric Ependymoma: Biological Perspectives. Molecular Cancer Research, 7(6), 765-786. https://doi.org/10.1158/1541-7786.mcr-08-0584

Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge despite advances in neurosurgery, neuroimaging techniques, and radiation therapy. Difficulty in predicting tumor behavior from clinical and histologic... Read More about Pediatric Ependymoma: Biological Perspectives.

Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm (2009)
Journal Article
Rahman, R., Heath, R., & Grundy, R. (2009). Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm. BBA - Molecular Basis of Disease, 1792(4), 280-288. https://doi.org/10.1016/j.bbadis.2009.01.011

Brain tumours are a diverse group of neoplasms that continue to present a formidable challenge in our attempt to achieve curable intervention. Our conceptual framework of human brain cancer has been redrawn in the current decade. There is a gathering... Read More about Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.

Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma (2008)
Journal Article
Ridley, L., Rahman, R., Brundler, M., Ellison, D., Lowe, J., Robson, K., …Grundy, R. G. (2008). Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. Neuro-Oncology, 10(5), 675–689. https://doi.org/10.1215/15228517-2008-036

Telomeric 3′-overhang length is associated with the size of telomeres (2008)
Journal Article
Rahman, R., Forsyth, N. R., & Cui, W. (2008). Telomeric 3′-overhang length is associated with the size of telomeres. Experimental Gerontology, 43(4), 258-265. https://doi.org/10.1016/j.exger.2008.01.005

Telomeres are specialized DNA/protein complexes that cap eukaryotic chromosome ends as T-loop structures and maintain genomic integrity. Vertebrate telomeric DNA consists of tandem double-strand repeats which terminate in a 3 0 single-strand G-rich o... Read More about Telomeric 3′-overhang length is associated with the size of telomeres.

Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth (2006)
Journal Article
Rahman, R., Mo, L., & Cui, W. (2006). Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth. Biochemical and Biophysical Research Communications, 350(3), 796-802. https://doi.org/10.1016/j.bbrc.2006.09.125

Telomerase catalytic subunit (TERT) seems a key factor controlling telomerase activity, telomere length, and cell growth. To further address this issue, we forced expression of a catalytically inactive mutant human TERT (hTERT) in hTERT-immortalised... Read More about Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth.