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All Outputs (2)

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease (2017)
Journal Article
Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikaud, A., Wearmouth, S. F., …Morris, J. C. (2017). Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease. ACS Chemical Biology, 12(3), 825-832. https://doi.org/10.1021/acschembio.6b01048

Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic isoforms to normal physiological levels. The lack of potency and selectivi... Read More about Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease.

Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells (2017)
Journal Article
Ahmed, M., Chaudhari, K., Babaei?Jadidi, R., Dekker, L. V., & Shams Nateri, A. (2017). Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells. STEM CELLS, 35(4), 839-850. https://doi.org/10.1002/stem.2579

Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem?like cell properties and which may be responsible for overall tumor maintenance. These cancer stem?like cells (CSCs) appear to have unique... Read More about Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells.