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COVID-19 and pregnancy: A comparison of case reports, case series and registry studies (2021)
Journal Article
Young, E. M., Green, O., Stewart, J., King, Y., O'Donoghue, K., Walker, K. F., & Thornton, J. G. (2022). COVID-19 and pregnancy: A comparison of case reports, case series and registry studies. European Journal of Obstetrics and Gynecology and Reproductive Biology, 268, 135-142. https://doi.org/10.1016/j.ejogrb.2021.12.002

Background: Selection, outcome and publication biases are well described in case reports and case series but may be less of a problem early in the appearance of a new disease when all cases might appear to be worth publishing. Objective: To use a pro... Read More about COVID-19 and pregnancy: A comparison of case reports, case series and registry studies.

The challenges of randomised control trials in obstetrics and gynaecology (2021)
Journal Article
Harper, S. L., Thornton, J. G., & Walker, K. F. (2021). The challenges of randomised control trials in obstetrics and gynaecology. Obstetrics, Gynaecology and Reproductive Medicine, 31(2), 59-60. https://doi.org/10.1016/j.ogrm.2020.12.006

In this short article we explore some of the challenges faced by those conducting randomised trials in obstetrics and gynaecology. We discuss the current status of trials comparing induction of labour versus expectant management, so called ‘deliver o... Read More about The challenges of randomised control trials in obstetrics and gynaecology.

Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations (2020)
Journal Article
Vasavan, T., Deepak, S., Jayawardane, I. A., Lucchini, M., Martin, C., Geenes, V., …Williamson, C. (2021). Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations. Journal of Hepatology, 74(5), 1087-1096. https://doi.org/10.1016/j.jhep.2020.11.038

Background & Aims: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of stillbirth. This study aimed to assess the relationship between bile acid concentrations and fetal cardiac dysfunction in patients with ICP who wer... Read More about Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.

Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure (2020)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J., Walker, K., Medrano, J. H., Castellanos, M., …Maalouf, W. E. (2021). Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure. Reproductive BioMedicine Online, 42(3), 595-608. https://doi.org/10.1016/j.rbmo.2020.10.018

Research question What is the difference in endometrial transcriptomics between women with normal and with low mid-luteal progesterone during the implantation window? Design An endometrial biopsy and serum progesterone concentration were taken f... Read More about Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure.

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial (2020)
Journal Article
Fleminger, J., Seed, P., Smith, A., Dixon, P., Juszczak, E., Chambers, J., …Chappell, L. (2021). Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial. BJOG: An International Journal of Obstetrics and Gynaecology, 128(6), 1066-1075. https://doi.org/10.1111/1471-0528.16567

Objective: To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA). Design: Secondary analysis of the P... Read More about Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial.

Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy (2020)
Journal Article
Moraitis, A. A., Shreeve, N., Sovio, U., Brocklehurst, P., Heazell, A. E. P., Thornton, J. G., …Smith, G. C. (2020). Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy. PLoS Medicine, 17(10), Article e1003190. https://doi.org/10.1371/journal.pmed.1003190

Background The effectiveness of screening for macrosomia is not well established. One of the critical elements of an effective screening program is the diagnostic accuracy of a test at predicting the condition. The objective of this study is to inve... Read More about Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy.

Maternal transmission of SARS?COV?2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis (2020)
Journal Article
Walker, K., O'Donoghue, K., Grace, N., Dorling, J., Comeau, J. L., Li, W., & Thornton, J. (2020). Maternal transmission of SARS?COV?2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 127(11), 1324-1336. https://doi.org/10.1111/1471-0528.16362

Timing and mode of delivery with advancing maternal age (2020)
Journal Article
Walker, K. F., & Thornton, J. G. (2021). Timing and mode of delivery with advancing maternal age. Best Practice and Research: Clinical Obstetrics and Gynaecology, 70, 101-111. https://doi.org/10.1016/j.bpobgyn.2020.06.005

In 2017, 23% of all live births in the United Kingdom were to women aged over 35 years. Decisions around the timing of delivery for such women must balance the risks of prolongation of the pregnancy and of iatrogenic harm from timed delivery. Women o... Read More about Timing and mode of delivery with advancing maternal age.

The strength of evidence supporting luteal phase progestogen after assisted reproduction: A systematic review with reference to trial registration and pre-specified endpoints (2019)
Journal Article
Suthaporn, S., Jayaprakasan, K., Maalouf, W., Thornton, J. G., & Walker, K. F. (2020). The strength of evidence supporting luteal phase progestogen after assisted reproduction: A systematic review with reference to trial registration and pre-specified endpoints. European Journal of Obstetrics and Gynecology and Reproductive Biology, 245, 149-161. https://doi.org/10.1016/j.ejogrb.2019.12.002

Childbirth experience questionnaire 2: Validating its use in the United Kingdom (2019)
Journal Article
Walker, K. F., Dencker, A., & Thornton, J. G. (2020). Childbirth experience questionnaire 2: Validating its use in the United Kingdom. European Journal of Obstetrics && Gynecology and Reproductive Biology: X, 5, Article 100097. https://doi.org/10.1016/j.eurox.2019.100097

© 2019 The Authors Objective: To validate the Childbirth Experience Questionnaire 2 (CEQ2) in the UK to see if it is an effective tool for evaluating labour experience. Study design: The CEQ2 and part of the Care Quality Commission Maternity Survey (... Read More about Childbirth experience questionnaire 2: Validating its use in the United Kingdom.

Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial (2019)
Journal Article
Chappell, L. C., Brocklehurst, P., Green, M. E., Hunter, R., Hardy, P., Juszczak, E., …Wu, P. (2019). Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet, 394(10204), 1181-1190. https://doi.org/10.1016/s0140-6736%2819%2931963-4

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: In women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease... Read More about Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial.

Advanced maternal age (2019)
Journal Article
Walker, K. F., & Thornton, J. G. (2019). Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine, 29(9), 259-263. https://doi.org/10.1016/j.ogrm.2019.06.001

The average age of women at childbirth in industrialised nations has been increasing steadily for approximately 30 years. Women aged 35 years or over have an increased risk of gestational hypertensive disease, gestational diabetes, placenta praevia,... Read More about Advanced maternal age.

The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision analysis (2019)
Journal Article
Wastlund, D., Moraitis, A. A., Thornton, J. G., Sanders, J., White, I. R., Brocklehurst, P., …Wastlund, D. (2019). The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 126(10), 1243-1250. https://doi.org/10.1111/1471-0528.15809

Objective To identify the most cost‐effective policy for detection and management of fetal macrosomia in late‐stage pregnancy. Design Health economic simulation model. Setting All English NHS antenatal services. Population Nulliparous wo... Read More about The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision analysis.

Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting (2019)
Journal Article
White, V. A., Walker, K. F., & Thornton, J. G. (2019). Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting. European Journal of Obstetrics and Gynecology and Reproductive Biology, 236, 58-68. https://doi.org/10.1016/j.ejogrb.2019.02.031

Objective To measure the extent to which the evidence underpinning prenatal corticosteroids for preterm fetal lung maturity is at risk of bias due to selective outcome reporting. Study Design Five biomedical databases (Medline, ClinicalTrials.gov,... Read More about Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting.

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses (2019)
Journal Article
Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J., …Williamson, C. (2019). Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet, 393(10174), 899-909. https://doi.org/10.1016/s0140-6736%2818%2931877-4

Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic... Read More about Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses.

Maternal position in the second stage of labour for women with epidural anaesthesia (2018)
Journal Article
Walker, K. F., Kibuka, M., Thornton, J. G., & Jones, N. W. (2018). Maternal position in the second stage of labour for women with epidural anaesthesia. Cochrane Database of Systematic Reviews, 2018(11), Article CD008070. https://doi.org/10.1002/14651858.CD008070.pub4

© 2018 The Cochrane Collaboration. Background: Epidural analgesia in labour prolongs the second stage and increases instrumental delivery. It has been suggested that a more upright maternal position during all or part of the second stage may counter... Read More about Maternal position in the second stage of labour for women with epidural anaesthesia.