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All Outputs (57)

Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development (2023)
Journal Article
Cornwall, N., Knaggs, R., Woodcock, C., Ashworth, J., Harrisson, S. A., Dikomitis, L., …on behalf of the PROMPPT team. (2023). Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development. British Journal of Pain, https://doi.org/10.1177/20494637231221688

Introduction Regular review of patients prescribed opioids for persistent non-cancer pain (PCNP) is recommended but not routinely undertaken. The PROMPPT (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led... Read More about Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., …Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data (2023)
Journal Article
Coates, G., Clewes, P., Lohan, C., Stevenson, H., Wood, R., Tritton, T., …Walsh, D. (2023). Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data. BMJ Open, 13(7), Article e067545. https://doi.org/10.1136/bmjopen-2022-067545

Objective: Despite the prevalence of osteoarthritis (OA) in England, few studies have examined the health economic impact of chronic pain associated with OA. The aim of this study was to compare outcomes in patients with moderate-to-severe chronic pa... Read More about Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data.

Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis (2023)
Journal Article
Liu, S., Athar, A., Quach, D., Patanwala, A. E., Naylor, J. M., Stevens, J. A., …Penm, J. (2023). Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis. Anaesthesia, 78(10), 1225-1236. https://doi.org/10.1111/anae.16085

Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the availabl... Read More about Risks and benefits of oral modified-release compared with oral immediate-release opioid use after surgery: a systematic review and meta-analysis.

Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study (2023)
Journal Article
Liu, S., Patanwala, A. E., Naylor, J. M., Levy, N., Knaggs, R., Stevens, J. A., …Penm, J. (2023). Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study. Anaesthesia, 78(10), 1237-1248. https://doi.org/10.1111/anae.16070

Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of... Read More about Impact of modified-release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score-matched cohort study.

Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England (2023)
Journal Article
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R. D., & Lobo, D. N. (2023). Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia, 78(9), 1081-1092. https://doi.org/10.1111/anae.16055

This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative... Read More about Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. (0000). The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study (2022)
Journal Article
Anderson, C., Iqbal, A., Knaggs, R., & Toh, L. S. (2023). Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study. International Journal of Clinical Pharmacy, 45, 220-232. https://doi.org/10.1007/s11096-022-01493-6

Background Opioids are commonly used for the management of chronic non-malignant pain in Pakistan; but there is a lack of literature around precursors or motivators in the use of opioids. Aim The study holistically explored factors contributing towa... Read More about Logic model for opioid safety in chronic non-malignant pain management, an in-depth qualitative study.

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

System-level policies on appropriate opioid use, a multi-stakeholder consensus (2022)
Journal Article
Forget, P., Patullo, C., Hill, D., Ambekar, A., Baldacchino, A., Cata, J., …Gilbert, S. (2022). System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Services Research, 22(1), Article 329. https://doi.org/10.1186/s12913-022-07696-x

Background: This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may he... Read More about System-level policies on appropriate opioid use, a multi-stakeholder consensus.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article
Baamer, R. M., Iqbal, A., Lobo, D. N., Knaggs, R. D., Levy, N. A., & Toh, L. S. (2022). Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review. British Journal of Anaesthesia, 128(5), 874-888. https://doi.org/10.1016/j.bja.2021.11.032

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study (2021)
Journal Article
Chen, T., Knaggs, R. D., & Chen, L. (2021). Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study. British Journal of Anaesthesia, 127(5), 789-797. https://doi.org/10.1016/j.bja.2021.06.049

Background Opioid-overdose deaths are associated with poisoning with prescription and illicit opioids in the USA. In contrast, opioid-related deaths (ORDs) in the UK often involve drugs and substances of misuse, and may not be associated with a hi... Read More about Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study.

Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study (2021)
Journal Article
Chen, T., Knaggs, R. D., & Chen, L. (2022). Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study. British Journal of Clinical Pharmacology, 88(2), 798-809. https://doi.org/10.1111/bcp.15028

Aim This study aimed to evaluate the association between opioid-related deaths and persistent opioid utilisation in the United Kingdom (UK). Methods This nested case-control study used the UK Clinical Practice Research Datalink, linking the Offi... Read More about Association between opioid‐related deaths and persistent opioid prescribing in primary care in England: a nested case‐control study.