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Comparison of different human tissue processing methods for maximization of bacterial recovery (2018)
Journal Article
Askar, M., Ashraf, W., Scammell, B., & Bayston, R. (2019). Comparison of different human tissue processing methods for maximization of bacterial recovery. European Journal of Clinical Microbiology and Infectious Diseases, 38(1), 149-155. doi:10.1007/s10096-018-3406-4

Tissues are valuable microbiological samples that have proved superiority over swabs. Culture of tissue samples is used in the diagnosis of a variety of infections. However, as well as factors such as the site of obtaining the sample, the number of s... Read More

Cerebrospinal fluid shunt infection: microbiological basis (2018)
Book
Bayston, R. (2018). Cerebrospinal fluid shunt infection: microbiological basis. In M. M. Ozek, C. Sainte-Rose, & G. Cinalli (Eds.), Pediatric hydrocephalus, 1-19. Cham: Springer Publishing Company. doi:10.1007/978-3-319-31889-9_76-1

Shunt infection rates have fallen in recent decades but are still too high, especially when infants under 6 months of age are shunted. The causative bacteria are mainly staphylococci derived from the patient’s skin during operation. Bacteria develop... Read More

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection (2018)
Journal Article
Askar, M., Bloch, B., & Bayston, R. (2018). Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection. Arthroplasty Today, 4(3), 257-260. doi:10.1016/j.artd.2018.06.003

Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenot... Read More

Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis? (2015)
Journal Article
Bayston, R., Ashraf, W., & Ortori, C. (2015). Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?. Journal of Neurosurgery, 124(2), doi:10.3171/2014.12.JNS141900. ISSN 0022-3085

OBJECT Recently concern has arisen over the effect of released antimicrobial agents from antibiotic-impregnated external ventricular drainage (EVD) catheters on the reliability of CSF culture for diagnosis of ventriculitis. The authors designed a... Read More

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model (2014)
Journal Article
McLaren, J. S., White, L., Cox, H., Ashraf, W., Rahman, C., Blunn, G., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model. eCells and Materials Journal, 27, doi:10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More

Bacterial involvement in otitis media with effusion (2012)
Journal Article
Daniel, M., Imtiaz-Umer, S., Fergie, N., Birchall, J., & Bayston, R. (2012). Bacterial involvement in otitis media with effusion. International Journal of Pediatric Otorhinolaryngology, 76(10), doi:10.1016/j.ijporl.2012.06.013. ISSN 0165-5876

Objective Otitis media with effusion (OME), a common chronic childhood condition affecting hearing, is thought to be a result of bacterial infection, with biofilms recently implicated. Although bacterial DNA can be detected by polymerase chain react... Read More

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), doi:10.1038/nbt.2316. ISSN 1087-0156

Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics... Read More

The use of the ASET in the diagnosis of ventriculoatrial shunt infection: a case report (2012)
Journal Article
Reaper, J., Collins, S. A., & Bayston, R. (2012). The use of the ASET in the diagnosis of ventriculoatrial shunt infection: a case report. BMJ Case Reports, doi:10.1136/bcr.2012.006164. ISSN 1757-790X

A 38yr-old male with a ventriculoatrial shunt presented with nonspecific symptoms (headache, back pain, night sweats) and inconclusive laboratory results. He showed an extremely high titre of antibody to Staphylococcus epidermidis which proved diagno... Read More

Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro (2012)
Journal Article
Bayston, R., Ullas, G., & Ashraf, W. (2012). Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro. Antimicrobial Agents and Chemotherapy, 56(6), doi:10.1128/AAC.06326-11. ISSN 0066-4804

Cerebrospinal fluid (CSF) shunts used to treat hydrocephalus have an overall infection rate of about 10% of operations. The commonest causative bacteria are Staphylococcus epidermidis, followed by Staphylococcus aureus and enterococci. Major difficul... Read More