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A Three-Dimensional Model of Bacterial Biofilms and Its Use in Antimicrobial Susceptibility Testing (2024)
Journal Article
Ali, H. R., Collier, P., & Bayston, R. (2024). A Three-Dimensional Model of Bacterial Biofilms and Its Use in Antimicrobial Susceptibility Testing. Microorganisms, 12(1), Article 203. https://doi.org/10.3390/microorganisms12010203

(1) Background: The discrepant antimicrobial susceptibility between planktonic and biofilm bacterial modes poses a problem for clinical microbiology laboratories and necessitates a relevant 3D experimental model allowing bacteria to grow in biofilm m... Read More about A Three-Dimensional Model of Bacterial Biofilms and Its Use in Antimicrobial Susceptibility Testing.

Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis (2023)
Journal Article
Taal, M. W., Dukka, H., & Bayston, R. (2023). Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis. Expert Review of Medical Devices, 20(6), 459-466. https://doi.org/10.1080/17434440.2023.2205587

Introduction Peritoneal dialysis (PD) is a widely used dialysis modality, which offers the advantage of being a home therapy but is associated with a risk of potentially serious infections, including exit site infection, catheter tunnel infection, a... Read More about Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis.

Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers (2022)
Journal Article
Wang, D. Y., Su, L., Yang, G., Ren, Y., Zhang, M., Jing, H., …Shi, L. (2022). Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers. Journal of Materials Chemistry B, 10(14), 2316-2322. https://doi.org/10.1039/d1tb02647j

Self-targeting antimicrobial platforms have yielded new possibilities for the treatment of infectious biofilms. Self-targeting involves stealth transport through the blood circulation towards an infectious biofilm, where the antimicrobial platform pe... Read More about Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers.

Capsule formation around breast implants (2021)
Journal Article
Bayston, R. (2022). Capsule formation around breast implants. Journal of Plastic, Reconstructive and Aesthetic Surgery, 31, 123-128. https://doi.org/10.1016/j.jpra.2021.11.004

All implants are rapidly coated by the host with glycoproteins forming a thin capsule, and this is a normal response. Where an inflammatory stimulus such as infection is present, the capsule can thicken and become microvascularised and sometimes calc... Read More about Capsule formation around breast implants.

Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery (2021)
Journal Article
Tanner, J., Timmons, S., Bayston, R., Adams, K., & Baxendale, B. (2021). Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery. BMJ Open Quality, 10(1), Article e001132. https://doi.org/10.1136/bmjoq-2020-001132

© Background The first step in bundle design or implementation is to identify the problem being addressed. Several validated approaches are recommended to facilitate this. These include using systematic reviews, adverse event triggers and risk asses... Read More about Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery.

Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model (2020)
Journal Article
Gorelick, N. L., Serra, R., Iyer, R., Um, R., Grewal, A., Monroe, A., …Luciano, M. G. (2020). Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model. Neurosurgery, 87(5), 1046-1054. https://doi.org/10.1093/neuros/nyaa203

BACKGROUND Hydrocephalus is managed by surgically implanting flow-diversion technologies such as differential pressure valves and antisiphoning devices; however, such hardware is prone to failure. Extensive research has tested them in flow-control... Read More about Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model.

Development of dual anti-biofilm and anti-bacterial medical devices (2020)
Journal Article
Burroughs, L., Singh, S., Ashraf, W., Martinez-Pomares, L., Bayston, R., & Hook, A. L. (2020). Development of dual anti-biofilm and anti-bacterial medical devices. Biomaterials Science, 8(14), 3926-3934. https://doi.org/10.1039/d0bm00709a

The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-... Read More about Development of dual anti-biofilm and anti-bacterial medical devices.

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article
Marsit, N. M., Sidney, L. E., Britchford, E. R., McIntosh, O. D., Allen, C. L., Ashraf, W., …Hopkinson, A. (2019). Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane. Scientific Reports, 9(1), Article 12854. https://doi.org/10.1038/s41598-019-49314-7

© 2019, The Author(s). Amniotic membrane (AM) is used to treat a range of ophthalmic indications but must be presented in a non-contaminated state. AM from elective caesarean sections contains natural microbial contamination, requiring removal during... Read More about Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane.

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study (2019)
Journal Article
Baystson, R., Ashraf, W., Pelegrin, I., Fowkes, K., Bienemann, A. S., Singleton, W. G., & Scott, I. S. (2019). An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study. Journal of Antimicrobial Chemotherapy, 74(10), 2959-2964. https://doi.org/10.1093/jac/dkz293

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. BACKGROUND: External ventricular drainage (EVD) carries a high risk of ventriculitis, increasingly caused by MDR Gram-negative... Read More about An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study.

An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks (2019)
Journal Article
Belfield, K., Chen, X., Smith, E. F., Ashraf, W., & Bayston, R. (2019). An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks. Acta Biomaterialia, 90, 157-168. https://doi.org/10.1016/j.actbio.2019.03.042

Two major complications of indwelling urinary catheterisation include infection and mineral encrustation of the catheter. Our antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin has demonstrated long-term pro... Read More about An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks.

Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results (2019)
Journal Article
Belfield, K., Kalith, S., Aimar, K., Parkinson, R., & Bayston, R. (2019). Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results. Journal of Medical Microbiology, 68(4), 549-554. https://doi.org/10.1099/jmm.0.000946

Purpose: To quantify and identify microorganisms attached to the lumens and balloons of removed urethral urinary catheters and relate this to patient-specific information. Methodology: Indwelling urethral urinary catheters were collected from pati... Read More about Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results.

A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection (2018)
Journal Article
Busscher, H. J., Alt, V., Van Der Mei, H. C., Fagette, P. H., Zimmerli, W., Moriarty, T. F., …Grainger, D. W. (2019). A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection. ACS Biomaterials Science and Engineering, 5(2), 402-406. https://doi.org/10.1021/acsbiomaterials.8b01071

Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers. Regulatory requ... Read More about A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection.

Comparison of different human tissue processing methods for maximization of bacterial recovery (2018)
Journal Article
Askar, M., Ashraf, W., Scammell, B., & Bayston, R. (2019). Comparison of different human tissue processing methods for maximization of bacterial recovery. European Journal of Clinical Microbiology and Infectious Diseases, 38(1), 149-155. https://doi.org/10.1007/s10096-018-3406-4

Tissues are valuable microbiological samples that have proved superiority over swabs. Culture of tissue samples is used in the diagnosis of a variety of infections. However, as well as factors such as the site of obtaining the sample, the number of s... Read More about Comparison of different human tissue processing methods for maximization of bacterial recovery.

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use (2018)
Journal Article
Belfield, K., Betts, H., Parkinson, R., & Bayston, R. (2018). A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use. Neurourology and Urodynamics, 38(1), 338-345. https://doi.org/10.1002/nau.23858

© 2018 Wiley Periodicals, Inc. Aims: We have developed a novel antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin and demonstrated that it has long-term (∼84 days) protection against bacterial colonization i... Read More about A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use.

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection (2018)
Journal Article
Askar, M., Bloch, B., & Bayston, R. (2018). Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection. Arthroplasty Today, 4(3), 257-260. https://doi.org/10.1016/j.artd.2018.06.003

Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenot... Read More about Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection.

A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland (2017)
Journal Article
Jamjoom, A., Joannides, A., Poon, M., Chari, A., Zaben, M., Abdullah, M., …Ahmed, A. (2018). A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland. Journal of Neurology, Neurosurgery and Psychiatry, 89, https://doi.org/10.1136/jnnp-2017-316415

Objectives External Ventricular Drain (EVD) insertion is a common neurosurgical procedure. EVD- related infection (ERI) is a major complication that can lead to morbidity and mortality. In this study, we aimed to establish a national ERI rate in t... Read More about A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland.

Evaluation of combinations of putative anti-biofilm agents and antibiotics to eradicate biofilms of Staphylococcus aureus and Pseudomonas aeruginosa (2017)
Journal Article
Belfield, K., Bayston, R., Hajduk, N., Levell, G., Birchall, J. P., & Daniel, M. (2017). Evaluation of combinations of putative anti-biofilm agents and antibiotics to eradicate biofilms of Staphylococcus aureus and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 72(9), 2531-2538. https://doi.org/10.1093/jac/dkx192

Objectives To evaluate potential anti-biofilm agents for their ability to enhance the activity of antibiotics for local treatment of localized biofilm infections. Methods Staphylococcus aureus and Pseudomonas aeruginosa in vitro biofilm models... Read More about Evaluation of combinations of putative anti-biofilm agents and antibiotics to eradicate biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.