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All Outputs (19)

Emollients for prevention of atopic dermatitis: 5‐year findings from the BEEP randomized trial (2022)
Journal Article
Bradshaw, L. E., Wyatt, L. A., Brown, S. J., Haines, R. H., Montgomery, A. A., Perkin, M. R., …Williams, H. C. (2023). Emollients for prevention of atopic dermatitis: 5‐year findings from the BEEP randomized trial. Allergy, 78(4), 995-1006. https://doi.org/10.1111/all.15555

Background: The effectiveness of emollients for preventing atopic dermatitis/eczema is controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of daily emollients during the first year of life on atopic dermatitis and... Read More about Emollients for prevention of atopic dermatitis: 5‐year findings from the BEEP randomized trial.

Conduct and reporting of formula milk trials: systematic review (2021)
Journal Article
Helfer, B., Leonardi-Bee, J., Mundell, A., Parr, C., Ierodiakonou, D., Garcia-Larsen, V., …Boyle, R. J. (2021). Conduct and reporting of formula milk trials: systematic review. BMJ, 375, Article n2202. https://doi.org/10.1136/bmj.n2202

Importance: Formula milk is consumed by most infants in Europe and North America and global consumption is rising. New formula products need to be tested in clinical trials, but concerns have been raised that such trials are biased and may undermine... Read More about Conduct and reporting of formula milk trials: systematic review.

Skin care interventions in infants for preventing eczema and food allergy (2021)
Journal Article
Kelleher, M. M., Cro, S., Cornelius, V., Lodrup Carlsen, K. C., Skjerven, H. O., Rehbinder, E. M., …Boyle, R. J. (2021). Skin care interventions in infants for preventing eczema and food allergy. Cochrane Library, 2021(2), Article CD013534. https://doi.org/10.1002/14651858.cd013534.pub2

Background Eczema and food allergy are common health conditions that usually begin in early childhood and often occur together in the same people. They can be associated with an impaired skin barrier in early infancy. It is unclear whether trying... Read More about Skin care interventions in infants for preventing eczema and food allergy.

Test?guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST) (2021)
Journal Article
Ridd, M. J., Webb, D., Roberts, K., Santer, M., Chalmers, J. R., Gilbertson, A., …Boyle, R. J. (2021). Test‐guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST). Clinical and Experimental Allergy, 51(3), 452-462. https://doi.org/10.1111/cea.13816

Background Parents commonly ask about food allergy tests, to find a cause for their child's eczema, yet the value of routine testing is uncertain. Objective To determine whether a clinical trial comparing test‐guided dietary advice versus usual... Read More about Test?guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST).

Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy (2020)
Journal Article
Munblit, D., Perkin, M. R., Palmer, D. J., Allen, K. J., & Boyle, R. J. (2020). Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy. JAMA Pediatrics, 174(6), 599-608. https://doi.org/10.1001/jamapediatrics.2020.0153

Importance Sales of specialized formula for managing cow’s milk allergy (CMA) have increased, triggering concern that attribution of common infant symptoms, such as crying, vomiting, and rashes, to CMA may be leading to overdiagnosis, which could un... Read More about Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy.

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (2020)
Journal Article
Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., …Williams, H. C. (2020). Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. Lancet, 395(10228), 962-972. https://doi.org/10.1016/S0140-6736%2819%2932984-8

Background Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. Methods We did a multicentre, pragmatic, parallel-group, randomised contr... Read More about Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.

An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge (2020)
Journal Article
Kelleher, M. M., Montgomery, A. A., Jay, N., Perkin, M. R., Haines, R. H., Batt, R., …Boyle, R. J. (2020). An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge. Clinical and Experimental Allergy, 50(3), 334-342. https://doi.org/10.1111/cea.13577

© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd. Background: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore,... Read More about An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.

TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study (2019)
Journal Article
Ridd, M. J., Edwards, L., Santer, M., Chalmers, J. R., Waddell, L., Marriage, D., …Boyle, R. J. (2019). TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study. BMJ Open, 9(5), Article e028428. https://doi.org/10.1136/bmjopen-2018-028428

Background Early-onset eczema is associated with food allergy, and allergic reactions to foods can cause acute exacerbations of eczema. Parents often pursue dietary restrictions as a way of managing eczema and seek allergy testing for their childre... Read More about TEST (Trial of Eczema allergy Screening Tests): protocol for feasibility randomised controlled trial of allergy tests in children with eczema, including economic scoping and nested qualitative study.

Diet during pregnancy and infancy, and risk of allergic or autoimmune disease: a systematic review and meta-analysis (2018)
Journal Article
Garcia-Larsen, V., Ierodiakonou, D., Jarrold, K., Cunha, S., Chivinge, J., Robinson, Z., …Boyle, R. J. (2018). Diet during pregnancy and infancy, and risk of allergic or autoimmune disease: a systematic review and meta-analysis. PLoS Medicine, 15(2), Article e1002507. https://doi.org/10.1371/journal.pmed.1002507

Background: There is uncertainty about the influence of diet during pregnancy and infancy on a child’s immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease. Methods and fi... Read More about Diet during pregnancy and infancy, and risk of allergic or autoimmune disease: a systematic review and meta-analysis.

Timing of allergenic food to the introduction to the infant diet and risk of allergic or autoimmune disease: a systematic review and meta-analysis (2016)
Journal Article
Ierodiakonou, D., Garcia-Larsen, V., Logan, A., Groome, A., Cunha, S., Chivinge, J., …Boyle, R. J. (2016). Timing of allergenic food to the introduction to the infant diet and risk of allergic or autoimmune disease: a systematic review and meta-analysis. Journal of the American Medical Association, 316(11), 1181-1192. https://doi.org/10.1001/jama.2016.12623

Importance: Timing of introduction of allergenic foods to the infant diet may influence the risk of allergic or autoimmune disease, but the evidence for this has not been comprehensively synthesized. Objective: To systematically review and meta-a... Read More about Timing of allergenic food to the introduction to the infant diet and risk of allergic or autoimmune disease: a systematic review and meta-analysis.

Hydrolysed formula and risk of allergic or autoimmune disease: Systematic review and meta-analysis (2016)
Journal Article
Boyle, R. J., Ierodiakonou, D., Khan, T., Chivinge, J., Robinson, Z., Geoghegan, N., …Leonardi-Bee, J. (2016). Hydrolysed formula and risk of allergic or autoimmune disease: Systematic review and meta-analysis. BMJ, 352, Article i974. https://doi.org/10.1136/bmj.i974

© BMJ Publishing Group Ltd 2016. Objective To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease. Design Systematic review and meta-analysis, as part of a series of systematic reviews commis... Read More about Hydrolysed formula and risk of allergic or autoimmune disease: Systematic review and meta-analysis.

Specific allergen immunotherapy for the treatment of atopic eczema (2016)
Journal Article
Tam, H., Calderon, M. A., Manikam, L., Nankervis, H., Núñez, I. G., Williams, H. C., & Boyle, R. (2016). Specific allergen immunotherapy for the treatment of atopic eczema. Cochrane Database of Systematic Reviews, Article CD008774. https://doi.org/10.1002/14651858.CD008774.pub2

BACKGROUND: Specific allergen immunotherapy (SIT) is a treatment that may improve disease severity in people with atopic eczema (AE) by inducing immune tolerance to the relevant allergen. A high quality systematic review has not previously assess... Read More about Specific allergen immunotherapy for the treatment of atopic eczema.

Increase in anaphylaxis-related hospitalizations but no increase in fatalities: An analysis of United Kingdom national anaphylaxis data, 1992-2012 (2014)
Journal Article
Turner, P. J., Gowland, M. H., Sharma, V., Ierodiakonou, D., Harper, N., Garcez, T., …Boyle, R. J. (2015). Increase in anaphylaxis-related hospitalizations but no increase in fatalities: An analysis of United Kingdom national anaphylaxis data, 1992-2012. Journal of Allergy and Clinical Immunology, 135(4), 956-963.e1. https://doi.org/10.1016/j.jaci.2014.10.021